Characterization of a novel t(2;5;11) in a patient with concurrent AML and CLL

A case report and literature review

Rui Zhang, Young Mi Kim, Xianglan Lu, Xianfu Wang, Hui Pang, Yan Li, Shibo Li, Ji-Yun Lee

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Acute myeloid leukemia (AML) that occurs concurrent with a diagnosis of chronic lymphocytic leukemia (CLL) is rare, but the number of cases recognized has recently dramatically increased as a result of the application of flow cytometry. This raises a series of questions regarding the clinical characterization of mixed leukemia, whether this diagnosis possesses unique cytogenetic abnormalities, and the possible association between AML and CLL cell clones. The current study attempts to answer these questions by evaluating an 80-year-old man with concurrent diagnoses of AML-M0 and CLL. Routine G-banded chromosome, array based comparative genomic hybridization, and fluorescence in situ hybridization analyses were used to characterize complex chromosomal rearrangements in the patient's bone marrow. Novel complex translocations involving chromosomes 2, 5, and 11, as well as submicroscopic deletions and duplications, were revealed. This case study reports a t(2;5;11) in either AML-M0 or in CLL by using array based comparative genomic hybridization and fluorescence in situ hybridization analyses to facilitate the diagnosis. The study also delineates the clinical characteristics and cytogenetic changes that occur with concurrent AML and CLL.

Original languageEnglish
Pages (from-to)328-333
Number of pages6
JournalCancer genetics
Volume204
Issue number6
DOIs
Publication statusPublished - 2011 Jun 1
Externally publishedYes

Fingerprint

B-Cell Chronic Lymphocytic Leukemia
Acute Myeloid Leukemia
Comparative Genomic Hybridization
Fluorescence In Situ Hybridization
In Situ Hybridization
Chromosomes, Human, 21-22 and Y
Chromosomes, Human, Pair 5
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 2
Cytogenetics
Chromosome Aberrations
Flow Cytometry
Leukemia
Clone Cells
Bone Marrow

Keywords

  • AML
  • Array CGH
  • Chromosome
  • CLL
  • FISH

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Characterization of a novel t(2;5;11) in a patient with concurrent AML and CLL : A case report and literature review. / Zhang, Rui; Kim, Young Mi; Lu, Xianglan; Wang, Xianfu; Pang, Hui; Li, Yan; Li, Shibo; Lee, Ji-Yun.

In: Cancer genetics, Vol. 204, No. 6, 01.06.2011, p. 328-333.

Research output: Contribution to journalArticle

Zhang, Rui ; Kim, Young Mi ; Lu, Xianglan ; Wang, Xianfu ; Pang, Hui ; Li, Yan ; Li, Shibo ; Lee, Ji-Yun. / Characterization of a novel t(2;5;11) in a patient with concurrent AML and CLL : A case report and literature review. In: Cancer genetics. 2011 ; Vol. 204, No. 6. pp. 328-333.
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