Characterization of glucose uptake metabolism in visceral fat by 18 F-FDG PET/CT reflects inflammatory status in metabolic syndrome

Kisoo Pahk, Eung Ju Kim, Yong Jik Lee, Sungeun Kim, Hong Seog Seo

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)

    Abstract

    Objective: The inflammatory activity of visceral adipose tissue (VAT) is elevated in metabolic syndrome (MS), and associated with vulnerability to atherosclerosis. Inflammation can be assessed by glucose uptake in atherosclerotic plaques. We investigated whether the glucose uptake of VAT, assessed by 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), is associated with systemic inflammatory status, and related to the number of MS components. Methods: 18F-FDG PET/CT was performed in a total of 203 participants: 59 without MS component; M (0), 92 with one or two MS components; M(1-2), and 52 with MS. Glucose uptake in VAT was evaluated using the mean standardized uptake value (SUVmean) and the maximum SUV (SUVmax). Glucose uptakes of immune-related organs such as the spleen and bone marrow (BM) were evaluated using the SUVmax. Results: VAT SUVmax correlated with high-sensitivity C-reactive protein (hsCRP) and the SUVmax of spleen and BM, which reflect the status of systemic inflammation. Both hsCRP and the SUVmax of the spleen and BM were higher in the MS group than in the M(1-2) or M(0) groups. In VAT, SUVmax increased with increasing number of MS components, while SUVmean decreased. Conclusions: The SUVmax and SUVmean of VAT assessed by 18F-FDG PET/CT reflected inflammation-driven unique glucose metabolism in the VAT of MS patients, distinct from that of atherosclerotic plaques.

    Original languageEnglish
    Article numbere0228602
    JournalPloS one
    Volume15
    Issue number2
    DOIs
    Publication statusPublished - 2020 Feb 1

    ASJC Scopus subject areas

    • General

    Fingerprint

    Dive into the research topics of 'Characterization of glucose uptake metabolism in visceral fat by <sup>18</sup> F-FDG PET/CT reflects inflammatory status in metabolic syndrome'. Together they form a unique fingerprint.

    Cite this