Characterization of Gp41 polymorphisms in the fusion peptide domain and T-20 (Enfuvirtide) resistance-associated regions in Korean HIV-1 isolates.

Dai Ho Jang, Cheol Hee Yoon, Byeong Sun Choi, Yoon Seok Chung, Hye Young Kim, Sung-Gil Chi, Sung Soon Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

HIV-1 gp41 is an envelope protein that plays an essential role in virus entry. The mutation of gp41 affects HIV-1 entry and susceptibility to the fusion inhibitor T-20. Therefore, we analyzed the natural polymorphism of gp41 of 163 HIV-1 isolates from T-20-naïve Koreans infected with HIV-1. This study of gp41 polymorphisms showed that insertions in the fourth threonine (74.8%) and L7M substitutions (85.3%) were more frequent in the fusion peptide motif in Korean HIV-1 isolates compared with those from other countries. Minor T-20 resistance mutations such as L45M (1.2%), N126K (1.2%), and E137K (6.7%) were detected, but the critical T-20 resistance mutations were not detected in the gp41 HR1 and HR2 regions. In addition, the N42S mutation (12.9%) associated with T-20 hypersusceptibility was detected at a high frequency. These results may serve as useful data for studies considering T-20 for use in the development of a more effective anti-retroviral treatment in Korea.

Original languageEnglish
Pages (from-to)456-459
Number of pages4
JournalJournal of Korean Medical Science
Volume29
Issue number3
DOIs
Publication statusPublished - 2014 Jan 1

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Peptide T
HIV-1
HIV Envelope Protein gp41
Mutation
Virus Internalization
Threonine
Korea
Peptides
enfuvirtide
Protein Domains

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Characterization of Gp41 polymorphisms in the fusion peptide domain and T-20 (Enfuvirtide) resistance-associated regions in Korean HIV-1 isolates. / Jang, Dai Ho; Yoon, Cheol Hee; Choi, Byeong Sun; Chung, Yoon Seok; Kim, Hye Young; Chi, Sung-Gil; Kim, Sung Soon.

In: Journal of Korean Medical Science, Vol. 29, No. 3, 01.01.2014, p. 456-459.

Research output: Contribution to journalArticle

Jang, Dai Ho ; Yoon, Cheol Hee ; Choi, Byeong Sun ; Chung, Yoon Seok ; Kim, Hye Young ; Chi, Sung-Gil ; Kim, Sung Soon. / Characterization of Gp41 polymorphisms in the fusion peptide domain and T-20 (Enfuvirtide) resistance-associated regions in Korean HIV-1 isolates. In: Journal of Korean Medical Science. 2014 ; Vol. 29, No. 3. pp. 456-459.
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