Characterization of hyaluronic acid-poly(ethylene oxide) hydrogel dependent upon poly(ethylene oxide)

Mi Sook Kim, Yoon Jeong Choi, Gun Woo Kim, Insup Noh, Yongdoo Park, Kyu Back Lee, In Sook Kim, Soon Jung Hwang, Gilwon Yoon

Research output: Contribution to journalArticle

Abstract

Characterization of an hyaluronic acid (HA)-poly(ethylene oxide) (PEO) hydrogel was performed by changing the number of side arms in a PEO molecule. Verification of grafting chemistry and mechanical strength, as well as swelling behaviors and surface morphologies of the HA-PEO hydrogels were analyzed by employing different x-linking molecular weights (MW) of PEO ranging from 1.7 to 5.0 kDa at a fixed low MW HA in the hydrogel network. Methacrylation to the HA successfully obtained via Michael type reaction between the methacrylate arm groups in HA and the thiol end groups in PEO was observed by XPS. Hydrogel formation was markedly dependent upon the numbers of thiol groups in the PEO molecule. Furthermore the lower MW PEO-based HA hydrogel demonstrated stronger mechanical properties but lower water absorption and the smaller pore sizes on its surface and cross section.

Original languageEnglish
Pages (from-to)749-752
Number of pages4
JournalKey Engineering Materials
Volume342-343
Publication statusPublished - 2007 Apr 16

Fingerprint

Hyaluronic acid
Hydrogel
Hyaluronic Acid
Polyethylene oxides
Hydrogels
Molecular weight
Sulfhydryl Compounds
Molecules
Methacrylates
Water absorption
Pore size
Strength of materials
Surface morphology
Swelling
X ray photoelectron spectroscopy
Mechanical properties

Keywords

  • Characterization
  • Hyaluronic acid
  • In situ hydrogel
  • Poly(ethylene oxide)

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemical Engineering (miscellaneous)

Cite this

Characterization of hyaluronic acid-poly(ethylene oxide) hydrogel dependent upon poly(ethylene oxide). / Kim, Mi Sook; Choi, Yoon Jeong; Kim, Gun Woo; Noh, Insup; Park, Yongdoo; Lee, Kyu Back; Kim, In Sook; Hwang, Soon Jung; Yoon, Gilwon.

In: Key Engineering Materials, Vol. 342-343, 16.04.2007, p. 749-752.

Research output: Contribution to journalArticle

Kim, MS, Choi, YJ, Kim, GW, Noh, I, Park, Y, Lee, KB, Kim, IS, Hwang, SJ & Yoon, G 2007, 'Characterization of hyaluronic acid-poly(ethylene oxide) hydrogel dependent upon poly(ethylene oxide)', Key Engineering Materials, vol. 342-343, pp. 749-752.
Kim, Mi Sook ; Choi, Yoon Jeong ; Kim, Gun Woo ; Noh, Insup ; Park, Yongdoo ; Lee, Kyu Back ; Kim, In Sook ; Hwang, Soon Jung ; Yoon, Gilwon. / Characterization of hyaluronic acid-poly(ethylene oxide) hydrogel dependent upon poly(ethylene oxide). In: Key Engineering Materials. 2007 ; Vol. 342-343. pp. 749-752.
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AU - Park, Yongdoo

AU - Lee, Kyu Back

AU - Kim, In Sook

AU - Hwang, Soon Jung

AU - Yoon, Gilwon

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