Characterization of hyaluronic acid-poly(ethylene oxide) hydrogel dependent upon poly(ethylene oxide)

Mi Sook Kim, Yoon Jeong Choi, Gun Woo Kim, Insup Noh, Yongdoo Park, Kyu Back Lee, In Sook Kim, Soon Jung Hwang, Gilwon Yoon

Research output: Contribution to journalArticle

Abstract

Characterization of an hyaluronic acid (HA)-poly(ethylene oxide) (PEO) hydrogel was performed by changing the number of side arms in a PEO molecule. Verification of grafting chemistry and mechanical strength, as well as swelling behaviors and surface morphologies of the HA-PEO hydrogels were analyzed by employing different x-linking molecular weights (MW) of PEO ranging from 1.7 to 5.0 kDa at a fixed low MW HA in the hydrogel network. Methacrylation to the HA successfully obtained via Michael type reaction between the methacrylate arm groups in HA and the thiol end groups in PEO was observed by XPS. Hydrogel formation was markedly dependent upon the numbers of thiol groups in the PEO molecule. Furthermore the lower MW PEO-based HA hydrogel demonstrated stronger mechanical properties but lower water absorption and the smaller pore sizes on its surface and cross section.

Original languageEnglish
Pages (from-to)749-752
Number of pages4
JournalKey Engineering Materials
Volume342-343
DOIs
Publication statusPublished - 2007

Keywords

  • Characterization
  • Hyaluronic acid
  • In situ hydrogel
  • Poly(ethylene oxide)

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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