Characterization of lipid-rich plaques using spectroscopic optical coherence tomography

Hyeong Soo Nam, Joon Woo Song, Sun Joo Jang, Jae Joong Lee, Wang Yuhl Oh, Jin Won Kim, Hongki Yooa

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Intravascular optical coherence tomography (IV-OCT) is a high-resolution imaging method used to visualize the internal structures of walls of coronary arteries in vivo. However, accurate characterization of atherosclerotic plaques with gray-scale IV-OCT images is often limited by various intrinsic artifacts. In this study, we present an algorithm for characterizing lipid-rich plaques with a spectroscopic OCT technique based on a Gaussian center of mass (GCOM) metric. The GCOM metric, which reflects the absorbance properties of lipids, was validated using a lipid phantom. In addition, the proposed characterization method was successfully demonstrated in vivo using an atherosclerotic rabbit model and was found to have a sensitivity and specificity of 94.3% and 76.7% for lipid classification, respectively.

Original languageEnglish
Article number075004
JournalJournal of biomedical optics
Volume21
Issue number7
DOIs
Publication statusPublished - 2016 Jul 1

Keywords

  • lipid-rich plaque
  • optical coherence tomography
  • spectroscopic optical coherence tomography
  • tissue characterization

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

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