Abstract
Intravascular optical coherence tomography (IV-OCT) is a high-resolution imaging method used to visualize the internal structures of walls of coronary arteries in vivo. However, accurate characterization of atherosclerotic plaques with gray-scale IV-OCT images is often limited by various intrinsic artifacts. In this study, we present an algorithm for characterizing lipid-rich plaques with a spectroscopic OCT technique based on a Gaussian center of mass (GCOM) metric. The GCOM metric, which reflects the absorbance properties of lipids, was validated using a lipid phantom. In addition, the proposed characterization method was successfully demonstrated in vivo using an atherosclerotic rabbit model and was found to have a sensitivity and specificity of 94.3% and 76.7% for lipid classification, respectively.
| Original language | English |
|---|---|
| Article number | 075004 |
| Journal | Journal of Biomedical Optics |
| Volume | 21 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2016 Jul 1 |
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Keywords
- lipid-rich plaque
- optical coherence tomography
- spectroscopic optical coherence tomography
- tissue characterization
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Atomic and Molecular Physics, and Optics
- Biomedical Engineering
Cite this
Characterization of lipid-rich plaques using spectroscopic optical coherence tomography. / Nam, Hyeong Soo; Song, Joon Woo; Jang, Sun Joo; Lee, Jae Joong; Oh, Wang Yuhl; Kim, Jin Won; Yooa, Hongki.
In: Journal of Biomedical Optics, Vol. 21, No. 7, 075004, 01.07.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Characterization of lipid-rich plaques using spectroscopic optical coherence tomography
AU - Nam, Hyeong Soo
AU - Song, Joon Woo
AU - Jang, Sun Joo
AU - Lee, Jae Joong
AU - Oh, Wang Yuhl
AU - Kim, Jin Won
AU - Yooa, Hongki
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Intravascular optical coherence tomography (IV-OCT) is a high-resolution imaging method used to visualize the internal structures of walls of coronary arteries in vivo. However, accurate characterization of atherosclerotic plaques with gray-scale IV-OCT images is often limited by various intrinsic artifacts. In this study, we present an algorithm for characterizing lipid-rich plaques with a spectroscopic OCT technique based on a Gaussian center of mass (GCOM) metric. The GCOM metric, which reflects the absorbance properties of lipids, was validated using a lipid phantom. In addition, the proposed characterization method was successfully demonstrated in vivo using an atherosclerotic rabbit model and was found to have a sensitivity and specificity of 94.3% and 76.7% for lipid classification, respectively.
AB - Intravascular optical coherence tomography (IV-OCT) is a high-resolution imaging method used to visualize the internal structures of walls of coronary arteries in vivo. However, accurate characterization of atherosclerotic plaques with gray-scale IV-OCT images is often limited by various intrinsic artifacts. In this study, we present an algorithm for characterizing lipid-rich plaques with a spectroscopic OCT technique based on a Gaussian center of mass (GCOM) metric. The GCOM metric, which reflects the absorbance properties of lipids, was validated using a lipid phantom. In addition, the proposed characterization method was successfully demonstrated in vivo using an atherosclerotic rabbit model and was found to have a sensitivity and specificity of 94.3% and 76.7% for lipid classification, respectively.
KW - lipid-rich plaque
KW - optical coherence tomography
KW - spectroscopic optical coherence tomography
KW - tissue characterization
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UR - http://www.scopus.com/inward/citedby.url?scp=84978971676&partnerID=8YFLogxK
U2 - 10.1117/1.JBO.21.7.075004
DO - 10.1117/1.JBO.21.7.075004
M3 - Article
C2 - 27391375
AN - SCOPUS:84978971676
VL - 21
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
SN - 1083-3668
IS - 7
M1 - 075004
ER -