Characterization of lipid-rich plaques using spectroscopic optical coherence tomography

Hyeong Soo Nam, Joon Woo Song, Sun Joo Jang, Jae Joong Lee, Wang Yuhl Oh, Jin Won Kim, Hongki Yooa

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Intravascular optical coherence tomography (IV-OCT) is a high-resolution imaging method used to visualize the internal structures of walls of coronary arteries in vivo. However, accurate characterization of atherosclerotic plaques with gray-scale IV-OCT images is often limited by various intrinsic artifacts. In this study, we present an algorithm for characterizing lipid-rich plaques with a spectroscopic OCT technique based on a Gaussian center of mass (GCOM) metric. The GCOM metric, which reflects the absorbance properties of lipids, was validated using a lipid phantom. In addition, the proposed characterization method was successfully demonstrated in vivo using an atherosclerotic rabbit model and was found to have a sensitivity and specificity of 94.3% and 76.7% for lipid classification, respectively.

Original languageEnglish
Article number075004
JournalJournal of Biomedical Optics
Volume21
Issue number7
DOIs
Publication statusPublished - 2016 Jul 1

Fingerprint

Optical tomography
Optical Coherence Tomography
Lipids
lipids
tomography
center of mass
gray scale
rabbits
Atherosclerotic Plaques
arteries
Artifacts
artifacts
Coronary Vessels
Rabbits
Imaging techniques
Sensitivity and Specificity
sensitivity
high resolution

Keywords

  • lipid-rich plaque
  • optical coherence tomography
  • spectroscopic optical coherence tomography
  • tissue characterization

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

Cite this

Characterization of lipid-rich plaques using spectroscopic optical coherence tomography. / Nam, Hyeong Soo; Song, Joon Woo; Jang, Sun Joo; Lee, Jae Joong; Oh, Wang Yuhl; Kim, Jin Won; Yooa, Hongki.

In: Journal of Biomedical Optics, Vol. 21, No. 7, 075004, 01.07.2016.

Research output: Contribution to journalArticle

Nam, Hyeong Soo ; Song, Joon Woo ; Jang, Sun Joo ; Lee, Jae Joong ; Oh, Wang Yuhl ; Kim, Jin Won ; Yooa, Hongki. / Characterization of lipid-rich plaques using spectroscopic optical coherence tomography. In: Journal of Biomedical Optics. 2016 ; Vol. 21, No. 7.
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