Characterization of lipid-rich plaques using spectroscopic optical coherence tomography

Hyeong Soo Nam; Joon Woo Song; Sun Joo Jang; Jae Joong Lee; Wang Yuhl Oh; Jin Won Kim; Hongki Yooa

doi:10.1117/1.JBO.21.7.075004

Characterization of lipid-rich plaques using spectroscopic optical coherence tomography

Hyeong Soo Nam, Joon Woo Song, Sun Joo Jang, Jae Joong Lee, Wang Yuhl Oh, Jin Won Kim, Hongki Yooa

Department of Cardiology

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Intravascular optical coherence tomography (IV-OCT) is a high-resolution imaging method used to visualize the internal structures of walls of coronary arteries in vivo. However, accurate characterization of atherosclerotic plaques with gray-scale IV-OCT images is often limited by various intrinsic artifacts. In this study, we present an algorithm for characterizing lipid-rich plaques with a spectroscopic OCT technique based on a Gaussian center of mass (GCOM) metric. The GCOM metric, which reflects the absorbance properties of lipids, was validated using a lipid phantom. In addition, the proposed characterization method was successfully demonstrated in vivo using an atherosclerotic rabbit model and was found to have a sensitivity and specificity of 94.3% and 76.7% for lipid classification, respectively.

Original language	English
Article number	075004
Journal	Journal of biomedical optics
Volume	21
Issue number	7
DOIs	https://doi.org/10.1117/1.JBO.21.7.075004
Publication status	Published - 2016 Jul 1

Keywords

lipid-rich plaque
optical coherence tomography
spectroscopic optical coherence tomography
tissue characterization

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Biomedical Engineering

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abstract = "Intravascular optical coherence tomography (IV-OCT) is a high-resolution imaging method used to visualize the internal structures of walls of coronary arteries in vivo. However, accurate characterization of atherosclerotic plaques with gray-scale IV-OCT images is often limited by various intrinsic artifacts. In this study, we present an algorithm for characterizing lipid-rich plaques with a spectroscopic OCT technique based on a Gaussian center of mass (GCOM) metric. The GCOM metric, which reflects the absorbance properties of lipids, was validated using a lipid phantom. In addition, the proposed characterization method was successfully demonstrated in vivo using an atherosclerotic rabbit model and was found to have a sensitivity and specificity of 94.3% and 76.7% for lipid classification, respectively.",

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AU - Nam, Hyeong Soo

AU - Song, Joon Woo

AU - Jang, Sun Joo

AU - Lee, Jae Joong

AU - Oh, Wang Yuhl

AU - Kim, Jin Won

AU - Yooa, Hongki

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