Characterization of lipid-rich plaques using spectroscopic optical coherence tomography

Hyeong Soo Nam; Joon Woo Song; Sun Joo Jang; Jae Joong Lee; Wang Yuhl Oh; Jin Won Kim; Hongki Yooa

doi:10.1117/1.JBO.21.7.075004

Characterization of lipid-rich plaques using spectroscopic optical coherence tomography

Hyeong Soo Nam, Joon Woo Song, Sun Joo Jang, Jae Joong Lee, Wang Yuhl Oh, Jin Won Kim, Hongki Yooa

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Intravascular optical coherence tomography (IV-OCT) is a high-resolution imaging method used to visualize the internal structures of walls of coronary arteries in vivo. However, accurate characterization of atherosclerotic plaques with gray-scale IV-OCT images is often limited by various intrinsic artifacts. In this study, we present an algorithm for characterizing lipid-rich plaques with a spectroscopic OCT technique based on a Gaussian center of mass (GCOM) metric. The GCOM metric, which reflects the absorbance properties of lipids, was validated using a lipid phantom. In addition, the proposed characterization method was successfully demonstrated in vivo using an atherosclerotic rabbit model and was found to have a sensitivity and specificity of 94.3% and 76.7% for lipid classification, respectively.

Original language	English
Article number	075004
Journal	Journal of biomedical optics
Volume	21
Issue number	7
DOIs	https://doi.org/10.1117/1.JBO.21.7.075004
Publication status	Published - 2016 Jul 1

Keywords

lipid-rich plaque
optical coherence tomography
spectroscopic optical coherence tomography
tissue characterization

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomaterials
Biomedical Engineering

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10.1117/1.JBO.21.7.075004

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title = "Characterization of lipid-rich plaques using spectroscopic optical coherence tomography",

abstract = "Intravascular optical coherence tomography (IV-OCT) is a high-resolution imaging method used to visualize the internal structures of walls of coronary arteries in vivo. However, accurate characterization of atherosclerotic plaques with gray-scale IV-OCT images is often limited by various intrinsic artifacts. In this study, we present an algorithm for characterizing lipid-rich plaques with a spectroscopic OCT technique based on a Gaussian center of mass (GCOM) metric. The GCOM metric, which reflects the absorbance properties of lipids, was validated using a lipid phantom. In addition, the proposed characterization method was successfully demonstrated in vivo using an atherosclerotic rabbit model and was found to have a sensitivity and specificity of 94.3% and 76.7% for lipid classification, respectively.",

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AU - Nam, Hyeong Soo

AU - Song, Joon Woo

AU - Jang, Sun Joo

AU - Lee, Jae Joong

AU - Oh, Wang Yuhl

AU - Kim, Jin Won

AU - Yooa, Hongki

PY - 2016/7/1

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N2 - Intravascular optical coherence tomography (IV-OCT) is a high-resolution imaging method used to visualize the internal structures of walls of coronary arteries in vivo. However, accurate characterization of atherosclerotic plaques with gray-scale IV-OCT images is often limited by various intrinsic artifacts. In this study, we present an algorithm for characterizing lipid-rich plaques with a spectroscopic OCT technique based on a Gaussian center of mass (GCOM) metric. The GCOM metric, which reflects the absorbance properties of lipids, was validated using a lipid phantom. In addition, the proposed characterization method was successfully demonstrated in vivo using an atherosclerotic rabbit model and was found to have a sensitivity and specificity of 94.3% and 76.7% for lipid classification, respectively.

AB - Intravascular optical coherence tomography (IV-OCT) is a high-resolution imaging method used to visualize the internal structures of walls of coronary arteries in vivo. However, accurate characterization of atherosclerotic plaques with gray-scale IV-OCT images is often limited by various intrinsic artifacts. In this study, we present an algorithm for characterizing lipid-rich plaques with a spectroscopic OCT technique based on a Gaussian center of mass (GCOM) metric. The GCOM metric, which reflects the absorbance properties of lipids, was validated using a lipid phantom. In addition, the proposed characterization method was successfully demonstrated in vivo using an atherosclerotic rabbit model and was found to have a sensitivity and specificity of 94.3% and 76.7% for lipid classification, respectively.

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KW - spectroscopic optical coherence tomography

KW - tissue characterization

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Characterization of lipid-rich plaques using spectroscopic optical coherence tomography

Abstract

Keywords

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