Characterization of neural cell types expressing peroxiredoxins in mouse brain

Mei Hua Jin, Young Ho Lee, Jin Man Kim, Hu Nan Sun, Eun Yi Moon, Min Ho Shong, Sun Uk Kim, Sang Ho Lee, Tae Hoon Lee, Dae Yeul Yu, Dong Seok Lee

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

The differential expression patterns of antioxidant enzymes observed in the brains of patients with neurodegenerative diseases suggest an important role for reactive oxygen species and antioxidant enzymes in neurodegeneration. The six mammalian peroxiredoxins (Prxs) comprise a novel family of anti-oxidative proteins that are widely distributed in most tissues, but few studies of Prx in brain tissue have been reported. The specific histology of the neural cell types in which Prxs are expressed is an important issue related to biological function and defense against oxidative stress in the brain. This study analyzed mouse brain neural cell types expressing Prx isoforms using single- or double-label immunohistochemical techniques. In neurons, immunoreactivity for Prx II-V was observed in the cytoplasm. In particular, Prx II was found in the habenular nuclei, and Prx III and V were found in the stratum lucidum of the hippocampus. Astrocytes and microglia were immunoreactive only for Prx VI and Prx I, respectively. Prx I and IV immunoreactivity was apparent in oligodendrocytes, where it was principally localized in the nuclei. The observed distribution of Prx isoforms in the mammalian brain may be indicative of their specific roles in their preferred neural cell types and subcellular locales. The results of this study will help in unraveling the physiological and pathophysiological roles of the different Prx isoforms in neural function.

Original languageEnglish
Pages (from-to)252-257
Number of pages6
JournalNeuroscience Letters
Volume381
Issue number3
DOIs
Publication statusPublished - 2005 Jun 24

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Peroxiredoxins
Brain
Protein Isoforms
Antioxidants
Habenula
Oligodendroglia
Microglia
Enzymes
Astrocytes
Neurodegenerative Diseases
Reactive Oxygen Species
Hippocampus
Histology
Cytoplasm
Oxidative Stress
Neurons
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Jin, M. H., Lee, Y. H., Kim, J. M., Sun, H. N., Moon, E. Y., Shong, M. H., ... Lee, D. S. (2005). Characterization of neural cell types expressing peroxiredoxins in mouse brain. Neuroscience Letters, 381(3), 252-257. https://doi.org/10.1016/j.neulet.2005.02.048

Characterization of neural cell types expressing peroxiredoxins in mouse brain. / Jin, Mei Hua; Lee, Young Ho; Kim, Jin Man; Sun, Hu Nan; Moon, Eun Yi; Shong, Min Ho; Kim, Sun Uk; Lee, Sang Ho; Lee, Tae Hoon; Yu, Dae Yeul; Lee, Dong Seok.

In: Neuroscience Letters, Vol. 381, No. 3, 24.06.2005, p. 252-257.

Research output: Contribution to journalArticle

Jin, MH, Lee, YH, Kim, JM, Sun, HN, Moon, EY, Shong, MH, Kim, SU, Lee, SH, Lee, TH, Yu, DY & Lee, DS 2005, 'Characterization of neural cell types expressing peroxiredoxins in mouse brain', Neuroscience Letters, vol. 381, no. 3, pp. 252-257. https://doi.org/10.1016/j.neulet.2005.02.048
Jin, Mei Hua ; Lee, Young Ho ; Kim, Jin Man ; Sun, Hu Nan ; Moon, Eun Yi ; Shong, Min Ho ; Kim, Sun Uk ; Lee, Sang Ho ; Lee, Tae Hoon ; Yu, Dae Yeul ; Lee, Dong Seok. / Characterization of neural cell types expressing peroxiredoxins in mouse brain. In: Neuroscience Letters. 2005 ; Vol. 381, No. 3. pp. 252-257.
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