Characterization of the gel-spun tubular scaffold for cardiovascular tissue engineering

Eunna Chung, Sang Heon Kim, Young Gun Ko, Jae Hyun Kwon, Jeong Woo Han, In Su Park, Sung Sik Han, Soo Hyun Kim

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

A tubular and fibrous scaffold was fabricated from an elastic polymer, poly (L-lactide-co-e-caprolactone) (PLCL; Mn 193,813, Mw 538,623) 50:50 by using a novel gel spinning apparatus. To characterize the gel-spun scaffold, we investigated morphology, tensile property, tissue in-growth rate and degradation rate. From SEM images, fibrous structure in the scaffold wasn't fabricated well in the condition of 4% gel concentration. In general, the thickness level of microfibers increased as the gel concentration increased. In addition, the gel-spun scaffolds showed stronger tensile properties in the circumferential direction than the longitudinal direction. 5%, 7.5%, 10% and 12.5% scaffolds were analyzed in both directions: circumferential direction and longitudinal direction. On the other hand, the gel-spun scaffolds have been implanted in mouse to examine the degradation rate in vivo and tissue in-growth aspects, compared to extruded scaffolds. Both shows very similar degradation rates, but the aspect in tissue in-growth was different. In conclusion, gel-spun PLCL scaffolds have good characteristics as a plausible scaffold for cardiovascular tissue engineering.

Original languageEnglish
Pages (from-to)321-324
Number of pages4
JournalKey Engineering Materials
Volume342-343
DOIs
Publication statusPublished - 2007

Keywords

  • Bone marrow-derived stem cells
  • Cardiovascular tissue engineering
  • Gel spinning fabrication
  • Poly(L-lactide-co-ε-caprolactone) (PLCL)
  • Vascular graft

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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