Characterizing Intraorbital Optic Nerve Changes on Diffusion Tensor Imaging in Thyroid Eye Disease before Dysthyroid Optic Neuropathy

Hwa Lee, Young Hen Lee, Sang Il Suh, Eun Kee Jeong, Sehyun Baek, Hyung Suk Seo

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    7 Citations (Scopus)

    Abstract

    Objective The aim of this study was to determine whether the optic nerve is affected by thyroid eye disease (TED) before the development of dysthyroid optic neuropathy with diffusion-tensor imaging (DTI). Methods Twenty TED patients and 20 controls were included. The mean, axial, and radial diffusivities and fractional anisotropy (FA) value were measured at the optic nerves in DTI. Extraocular muscle diameters were measured on computed tomography. The diffusivities and FA of the optic nerves were compared between TED and controls and between active and inactive stages of TED. The correlations between these DTI parameters and the clinical features were determined. Results The mean, axial, and radial diffusivities were lower in TED compared with the controls (P < 0.05). In contrast, FA was higher in TED (P = 0.001). Radial diffusivity was lower in the active stage of TED than the inactive stage (P = 0.035). The FA was higher in the TED group than in the control group (P = 0.021) and was positively correlated with clinical activity score (r = 0.364, P = 0.021), modified NOSPECS score (r = 0.469, P = 0.002), and extraocular muscle thickness (r = 0.325, P = 0.041) in the TED group. Radial diffusivity was negatively correlated with modified NOSPECS score (r =-0.384, P = 0.014), and axial diffusivity was positively correlated with exophthalmos degree (r = 0.363, P = 0.025). Conclusions The diffusivities and FA reflected changes in the optic nerve before dysthyroid optic neuropathy in TED. The FA, in particular, reflected TED activity and severity.

    Original languageEnglish
    Pages (from-to)293-298
    Number of pages6
    JournalJournal of Computer Assisted Tomography
    Volume42
    Issue number2
    DOIs
    Publication statusPublished - 2018 Mar 1

    Keywords

    • diffusion-tensor imaging
    • dysthyroid optic neuropathy
    • medial rectus muscle
    • optic nerve
    • thyroid eye disease

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging

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