Charge-conversional polyionic complex micelles-efficient nanocarriers for protein delivery into cytoplasm

Yan Lee, Takehiko Ishii, Horacio Cabral, Hyun Jin Kim, Ji-Hun Seo, Nobuhiro Nishiyama, Hiroki Oshima, Kensuke Osada, Kazunori Kataoka

Research output: Contribution to journalArticle

219 Citations (Scopus)

Abstract

Special delivery! Polyionic complex (PIC) micelles that contain the charge-conversional moieties citaconic amide or cis-aconitic amide were developed for cytoplasmic protein delivery. The increase of the charge density on the protein cargo helped the stability of the PIC micelles without cross-linking, and the charge-conversion in endosomes induced the dissociation of the PIC micelles to result in efficient endosomal release (see picture).

Original languageEnglish
Pages (from-to)5309-5312
Number of pages4
JournalAngewandte Chemie - International Edition
Volume48
Issue number29
DOIs
Publication statusPublished - 2009 Jul 6
Externally publishedYes

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Micelles
Proteins
Amides
Charge density

Keywords

  • Charge conversion
  • Cytochromes
  • Drug delivery
  • Endosomes
  • Micelles

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

Charge-conversional polyionic complex micelles-efficient nanocarriers for protein delivery into cytoplasm. / Lee, Yan; Ishii, Takehiko; Cabral, Horacio; Kim, Hyun Jin; Seo, Ji-Hun; Nishiyama, Nobuhiro; Oshima, Hiroki; Osada, Kensuke; Kataoka, Kazunori.

In: Angewandte Chemie - International Edition, Vol. 48, No. 29, 06.07.2009, p. 5309-5312.

Research output: Contribution to journalArticle

Lee, Yan ; Ishii, Takehiko ; Cabral, Horacio ; Kim, Hyun Jin ; Seo, Ji-Hun ; Nishiyama, Nobuhiro ; Oshima, Hiroki ; Osada, Kensuke ; Kataoka, Kazunori. / Charge-conversional polyionic complex micelles-efficient nanocarriers for protein delivery into cytoplasm. In: Angewandte Chemie - International Edition. 2009 ; Vol. 48, No. 29. pp. 5309-5312.
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