Charge-conversional polyionic complex micelles-efficient nanocarriers for protein delivery into cytoplasm

Yan Lee, Takehiko Ishii, Horacio Cabral, Hyun Jin Kim, Ji-Hun Seo, Nobuhiro Nishiyama, Hiroki Oshima, Kensuke Osada, Kazunori Kataoka

Research output: Contribution to journalArticle

228 Citations (Scopus)


Special delivery! Polyionic complex (PIC) micelles that contain the charge-conversional moieties citaconic amide or cis-aconitic amide were developed for cytoplasmic protein delivery. The increase of the charge density on the protein cargo helped the stability of the PIC micelles without cross-linking, and the charge-conversion in endosomes induced the dissociation of the PIC micelles to result in efficient endosomal release (see picture).

Original languageEnglish
Pages (from-to)5309-5312
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number29
Publication statusPublished - 2009 Jul 6
Externally publishedYes



  • Charge conversion
  • Cytochromes
  • Drug delivery
  • Endosomes
  • Micelles

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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