Chemical characteristics of O-carboxymethyl chitosans related to the preparation conditions

Xi Guang Chen, Hyun Jin Park

Research output: Contribution to journalArticlepeer-review

580 Citations (Scopus)

Abstract

Carboxymethyl chitosan (CM-chitosan) was prepared by chemical reaction with monochloroacetic acid under various conditions, and the chemical structure was analyzed by IR and NMR. The water solubility of the CM-chitosans had close relationships to the modifying conditions and the degree of carboxymethylation. The CM-chitosans, prepared at temperatures of 0-10 °C were soluble in water. But the CM-chitosan prepared between 20 and 60 °C were insoluble in the water at near-neutral pH. The water insolubility of CM-chitosans at various pHs varied with the degree of carboxymethylation. The increase in reaction temperature increased the fraction of carboxymethylation and increased the insolubility at lower pHs; the increase of the ratio of water/isopropanol in the reaction solvent decreased the fraction of carboxymethylation and increased the insolubility at higher pHs.

Original languageEnglish
Pages (from-to)355-359
Number of pages5
JournalCarbohydrate Polymers
Volume53
Issue number4
DOIs
Publication statusPublished - 2003 Sep 1

Keywords

  • Carboxymethyl-chitosan
  • Carboxymethylation
  • Chemical nature
  • Chitosan
  • Water solubility

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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