Abstract
Carboxymethyl chitosan (CM-chitosan) was prepared by chemical reaction with monochloroacetic acid under various conditions, and the chemical structure was analyzed by IR and NMR. The water solubility of the CM-chitosans had close relationships to the modifying conditions and the degree of carboxymethylation. The CM-chitosans, prepared at temperatures of 0-10 °C were soluble in water. But the CM-chitosan prepared between 20 and 60 °C were insoluble in the water at near-neutral pH. The water insolubility of CM-chitosans at various pHs varied with the degree of carboxymethylation. The increase in reaction temperature increased the fraction of carboxymethylation and increased the insolubility at lower pHs; the increase of the ratio of water/isopropanol in the reaction solvent decreased the fraction of carboxymethylation and increased the insolubility at higher pHs.
Original language | English |
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Pages (from-to) | 355-359 |
Number of pages | 5 |
Journal | Carbohydrate Polymers |
Volume | 53 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2003 Sep 1 |
Keywords
- Carboxymethyl-chitosan
- Carboxymethylation
- Chemical nature
- Chitosan
- Water solubility
ASJC Scopus subject areas
- Organic Chemistry
- Polymers and Plastics
- Materials Chemistry