Chemical Constituents Isolated from Bletilla striata and Their Inhibitory Effects on Nitric Oxide Production in RAW 264.7 Cells

Joon Young Bae, Jin Woo Lee, Qinghao Jin, Hari Jang, Dongho Lee, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Moon Soon Lee, Bang Yeon Hwang

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3 Citations (Scopus)

Abstract

Bioassay-guided fractionation of the MeOH extract of the tubers of Bletilla striata led to the isolation of two new C-methylated flavan-3-ols, bletillanols A (1) and B (2), along with ten known compounds (3 – 12). Their structures were determined by using extensive spectroscopic analysis including 1D-, 2D-NMR, and circular dichroism data. All of the isolated compounds were tested for their inhibitory potential on the nitric oxide generation in LPS-stimulated RAW 264.7 cells.

Original languageEnglish
Article numbere1600243
JournalChemistry and Biodiversity
Volume14
Issue number2
DOIs
Publication statusPublished - 2017 Feb 1

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Keywords

  • Bletilla striata
  • Bletillanol A
  • Bletillanol B
  • Flavan-3-ol
  • Nitric oxide production
  • Orchidaceae

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology

Cite this

Bae, J. Y., Lee, J. W., Jin, Q., Jang, H., Lee, D., Kim, Y., Hong, J. T., Lee, M. K., Lee, M. S., & Hwang, B. Y. (2017). Chemical Constituents Isolated from Bletilla striata and Their Inhibitory Effects on Nitric Oxide Production in RAW 264.7 Cells. Chemistry and Biodiversity, 14(2), [e1600243]. https://doi.org/10.1002/cbdv.201600243