Chemical constituents isolated from the Mongolian medicinal plant Sophora alopecuroides L. and their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages

Jaeyoung Kwon, Sunita Basnet, Jin Woo Lee, Eun Kyoung Seo, Nanzad Tsevegsuren, Bang Yeon Hwang, Dongho Lee

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Abstract Three new flavonostilbenes, alopecurones M-O (1-3), were isolated from the root bark of Sophora alopecuroides L. together with 21 known compounds. The structures of the isolated compounds were elucidated by using NMR, MS, and CD spectroscopic data. All isolates were evaluated for their potential to inhibit LPS-induced nitric oxide production in RAW 264.7 cells.

Original languageEnglish
Article number22752
Pages (from-to)3314-3318
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume25
Issue number16
DOIs
Publication statusPublished - 2015 Jul 3

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Sophora
Macrophages
Medicinal Plants
Nitric Oxide
Nuclear magnetic resonance
RAW 264.7 Cells

Keywords

  • Flavonostilbenes
  • Nitric oxide production inhibitor
  • Sophora alopecuroides L.

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Chemical constituents isolated from the Mongolian medicinal plant Sophora alopecuroides L. and their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages. / Kwon, Jaeyoung; Basnet, Sunita; Lee, Jin Woo; Seo, Eun Kyoung; Tsevegsuren, Nanzad; Hwang, Bang Yeon; Lee, Dongho.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 25, No. 16, 22752, 03.07.2015, p. 3314-3318.

Research output: Contribution to journalArticle

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AU - Lee, Jin Woo

AU - Seo, Eun Kyoung

AU - Tsevegsuren, Nanzad

AU - Hwang, Bang Yeon

AU - Lee, Dongho

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