Chemical constituents isolated from the Mongolian medicinal plant Sophora alopecuroides L. and their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages

Jaeyoung Kwon, Sunita Basnet, Jin Woo Lee, Eun Kyoung Seo, Nanzad Tsevegsuren, Bang Yeon Hwang, Dongho Lee

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Abstract Three new flavonostilbenes, alopecurones M-O (1-3), were isolated from the root bark of Sophora alopecuroides L. together with 21 known compounds. The structures of the isolated compounds were elucidated by using NMR, MS, and CD spectroscopic data. All isolates were evaluated for their potential to inhibit LPS-induced nitric oxide production in RAW 264.7 cells.

Original languageEnglish
Article number22752
Pages (from-to)3314-3318
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume25
Issue number16
DOIs
Publication statusPublished - 2015 Jul 3

Keywords

  • Flavonostilbenes
  • Nitric oxide production inhibitor
  • Sophora alopecuroides L.

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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