Chemical Constituents Isolated from the Root Bark of Cudrania tricuspidata and Their Potential Neuroprotective Effects

Jaeyoung Kwon, Nguyen Tuan Hiep, Dong Woo Kim, Sungeun Hong, Yuanqiang Guo, Bang Yeon Hwang, Hak Ju Lee, Woongchon Mar, Dongho Lee

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Seventy-five compounds, including 21 new compounds (1-21), were isolated from the root bark of Cudrania tricuspidata. The structures of the isolated compounds were elucidated by interpretation of their spectroscopic data. All isolated compounds were evaluated for their neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced cell death, and nine compounds had activities with EC50 values of 1.9-30.2 μM. The 75 isolated compounds along with 34 previously reported xanthones were tested also for neuroprotective effects against the 1-methyl-4-phenylpyridinium ion (MPP+) and oxygen glucose deprivation (OGD)-induced cell death. Three compounds were active against MPP+-induced cell death with EC50 values of 0.2-10.3 μM, and 23 compounds were active in the OGD model with EC50 values of 2.9-35.5 μM.

Original languageEnglish
Pages (from-to)1938-1951
Number of pages14
JournalJournal of Natural Products
Volume79
Issue number8
DOIs
Publication statusPublished - 2016 Aug 26

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Moraceae
Neuroprotective Agents
Cell death
Cell Death
Oxidopamine
Xanthones
1-Methyl-4-phenylpyridinium
Oxygen
Glucose
Reactive Oxygen Species

ASJC Scopus subject areas

  • Analytical Chemistry
  • Medicine(all)
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Chemical Constituents Isolated from the Root Bark of Cudrania tricuspidata and Their Potential Neuroprotective Effects. / Kwon, Jaeyoung; Hiep, Nguyen Tuan; Kim, Dong Woo; Hong, Sungeun; Guo, Yuanqiang; Hwang, Bang Yeon; Lee, Hak Ju; Mar, Woongchon; Lee, Dongho.

In: Journal of Natural Products, Vol. 79, No. 8, 26.08.2016, p. 1938-1951.

Research output: Contribution to journalArticle

Kwon, Jaeyoung ; Hiep, Nguyen Tuan ; Kim, Dong Woo ; Hong, Sungeun ; Guo, Yuanqiang ; Hwang, Bang Yeon ; Lee, Hak Ju ; Mar, Woongchon ; Lee, Dongho. / Chemical Constituents Isolated from the Root Bark of Cudrania tricuspidata and Their Potential Neuroprotective Effects. In: Journal of Natural Products. 2016 ; Vol. 79, No. 8. pp. 1938-1951.
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