Chemical constituents of the egg cases of tenodera angustipennis (Mantidis ootheca) with intracellular reactive oxygen species scavenging activity

Seung Mok Ryu, Hyeon Hwa Nam, Joong Sun Kim, Jun Ho Song, Young Hye Seo, Hyo Seon Kim, A. Yeong Lee, Wook Jin Kim, Dongho Lee, Byeong Cheol Moon, Jun Lee

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

As a traditional medicine with potential antioxidant effects, Tenodera angustipennis egg cases (Mantidis ootheca) are a potential source of new bioactive substances. Herein, three new N-acetyldopamine derivatives, namely, (+)-tenoderin A (1a), (−)-tenoderin A (1b), and tenoderin B (2), along with thirteen known compounds (3–15), were isolated from a 70% EtOH extract of T. angustipennis egg cases. Compound 1 was isolated as a racemic mixture, and two enantiomers (1a and 1b) were successfully separated by chiral-phase preparative HPLC. The chemical structures of the new compounds were established by NMR spectroscopy and high-resolution electrospray ionization mass spectrometry, and the absolute configurations of enantiomers 1a and 1b were determined by electronic circular dichroism spectroscopy. All the new compounds exhibited antioxidant activities with IC50 values of 19.45–81.98 µM, as evaluated using free-radical scavenging assays, with the highest activity observed for compound 2. In addition, compounds 1a, 1b, and 2 exhibited inhibitory activities on intracellular reactive oxygen species generation.

Original languageEnglish
Article number556
JournalBiomolecules
Volume11
Issue number4
DOIs
Publication statusPublished - 2021

Keywords

  • Antioxidant activity
  • Mantidis ootheca
  • N-Acetyldopamine derivative
  • Tenodera angustipennis
  • Tenoderin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Fingerprint

Dive into the research topics of 'Chemical constituents of the egg cases of tenodera angustipennis (Mantidis ootheca) with intracellular reactive oxygen species scavenging activity'. Together they form a unique fingerprint.

Cite this