@article{55e29c176f374473a563710ccf1a9d7e,
title = "Chemical constituents of the leaves of butterbur (Petasites japonicus) and their anti-inflammatory effects",
abstract = "Two new aryltetralin lactone lignans, petasitesins A and B were isolated from the hot water extract of the leaves of butterbur (Petasites japonicus) along with six known compounds. The chemical structures of lignans 1 and 2 were elucidated on the basis of 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data, electronic circular dichroism (ECD) and vibrational circular dichroism (VCD) spectra. Petasitesin A and cimicifugic acid D showed significant inhibitory effects on the production of both prostaglandin E2 (PGE2) and NO in RAW264.7 macrophages. The expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were inhibited by compound 1 in RAW264.7 cells. Furthermore, compounds 1 and 3 exhibited strong affinities with both iNOS and COX-2 enzymes in molecular docking studies.",
keywords = "Anti-inflammation, Asteraceae, COX-2, INOS, Lignan, Molecular docking, NO, PGE2, Petasites japonicus",
author = "Lee, {Jin Su} and Miran Jeong and Sangsu Park and Ryu, {Seung Mok} and Jun Lee and Ziteng Song and Yuanqiang Guo and Choi, {Jung Hye} and Dongho Lee and Jang, {Dae Sik}",
note = "Funding Information: Funding: This research was supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry (IPET) through Agri-Bio Industry Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA), Republic of Korea (116044-1, 118046-03). This work was also supported by the National Research Foundation of Korea (NRF) grant funded by Ministry of Science and ICT (MSIT), Republic of Korea (NRF-2019R1A2C1083945). Funding Information: This research was supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry (IPET) through Agri-Bio Industry Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA), Republic of Korea (116044-1, 118046-03). This work was also supported by the National Research Foundation of Korea (NRF) grant funded by Ministry of Science and ICT (MSIT), Republic of Korea (NRF-2019R1A2C1083945). Publisher Copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2019",
doi = "10.3390/biom9120806",
language = "English",
volume = "9",
journal = "Biomolecules",
issn = "2218-273X",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "12",
}