Chemical constituents of the leaves of butterbur (Petasites japonicus) and their anti-inflammatory effects

Jin Su Lee; Miran Jeong; Sangsu Park; Seung Mok Ryu; Jun Lee; Ziteng Song; Yuanqiang Guo; Jung Hye Choi; Dongho Lee; Dae Sik Jang

doi:10.3390/biom9120806

Chemical constituents of the leaves of butterbur (Petasites japonicus) and their anti-inflammatory effects

Jin Su Lee, Miran Jeong, Sangsu Park, Seung Mok Ryu, Jun Lee, Ziteng Song, Yuanqiang Guo, Jung Hye Choi, Dongho Lee, Dae Sik Jang

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article

Abstract

Two new aryltetralin lactone lignans, petasitesins A and B were isolated from the hot water extract of the leaves of butterbur (Petasites japonicus) along with six known compounds. The chemical structures of lignans 1 and 2 were elucidated on the basis of 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data, electronic circular dichroism (ECD) and vibrational circular dichroism (VCD) spectra. Petasitesin A and cimicifugic acid D showed significant inhibitory effects on the production of both prostaglandin E2 (PGE2) and NO in RAW264.7 macrophages. The expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were inhibited by compound 1 in RAW264.7 cells. Furthermore, compounds 1 and 3 exhibited strong affinities with both iNOS and COX-2 enzymes in molecular docking studies.

Original language	English
Article number	806
Journal	Biomolecules
Volume	9
Issue number	12
DOIs	https://doi.org/10.3390/biom9120806
Publication status	Published - 2019 Jan 1

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Keywords

Anti-inflammation
Asteraceae
COX-2
INOS
Lignan
Molecular docking
NO
Petasites japonicus
PGE2

ASJC Scopus subject areas

Biochemistry
Molecular Biology

Cite this

Lee, J. S., Jeong, M., Park, S., Ryu, S. M., Lee, J., Song, Z., Guo, Y., Choi, J. H., Lee, D., & Jang, D. S. (2019). Chemical constituents of the leaves of butterbur (Petasites japonicus) and their anti-inflammatory effects. Biomolecules, 9(12), [806]. https://doi.org/10.3390/biom9120806

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abstract = "Two new aryltetralin lactone lignans, petasitesins A and B were isolated from the hot water extract of the leaves of butterbur (Petasites japonicus) along with six known compounds. The chemical structures of lignans 1 and 2 were elucidated on the basis of 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data, electronic circular dichroism (ECD) and vibrational circular dichroism (VCD) spectra. Petasitesin A and cimicifugic acid D showed significant inhibitory effects on the production of both prostaglandin E2 (PGE2) and NO in RAW264.7 macrophages. The expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were inhibited by compound 1 in RAW264.7 cells. Furthermore, compounds 1 and 3 exhibited strong affinities with both iNOS and COX-2 enzymes in molecular docking studies.",

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AU - Song, Ziteng

AU - Guo, Yuanqiang

AU - Choi, Jung Hye

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10.3390/biom9120806