Chemical constituents of the leaves of butterbur (Petasites japonicus) and their anti-inflammatory effects

Jin Su Lee, Miran Jeong, Sangsu Park, Seung Mok Ryu, Jun Lee, Ziteng Song, Yuanqiang Guo, Jung Hye Choi, Dongho Lee, Dae Sik Jang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Two new aryltetralin lactone lignans, petasitesins A and B were isolated from the hot water extract of the leaves of butterbur (Petasites japonicus) along with six known compounds. The chemical structures of lignans 1 and 2 were elucidated on the basis of 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data, electronic circular dichroism (ECD) and vibrational circular dichroism (VCD) spectra. Petasitesin A and cimicifugic acid D showed significant inhibitory effects on the production of both prostaglandin E2 (PGE2) and NO in RAW264.7 macrophages. The expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were inhibited by compound 1 in RAW264.7 cells. Furthermore, compounds 1 and 3 exhibited strong affinities with both iNOS and COX-2 enzymes in molecular docking studies.

Original languageEnglish
Article number806
JournalBiomolecules
Volume9
Issue number12
DOIs
Publication statusPublished - 2019 Jan 1

Keywords

  • Anti-inflammation
  • Asteraceae
  • COX-2
  • INOS
  • Lignan
  • Molecular docking
  • NO
  • Petasites japonicus
  • PGE2

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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  • Cite this

    Lee, J. S., Jeong, M., Park, S., Ryu, S. M., Lee, J., Song, Z., Guo, Y., Choi, J. H., Lee, D., & Jang, D. S. (2019). Chemical constituents of the leaves of butterbur (Petasites japonicus) and their anti-inflammatory effects. Biomolecules, 9(12), [806]. https://doi.org/10.3390/biom9120806