TY - JOUR
T1 - Chemical Probes and Activity‐Based Protein Profiling for Cancer Research
AU - Al Mazid, Mohammad Faysal
AU - Park, Seung Bin
AU - Cheekatla, Subba Rao
AU - Murale, Dhiraj P.
AU - Shin, Kyung Ho
AU - Lee, Jun Seok
N1 - Funding Information:
Funding: This work was supported by the National Research Foundation funded by the Ministry of Science, ICT, and Future Planning (NRF‐2018M3A9H4079286, NRF‐2020R1A2C2004422, and NRF‐2021H1D3A2A02080762).
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/6/1
Y1 - 2022/6/1
N2 - Chemical probes can be used to understand the complex biological nature of diseases. Due to the diversity of cancer types and dynamic regulatory pathways involved in the disease, there is a need to identify signaling pathways and associated proteins or enzymes that are traceable or detectable in tests for cancer diagnosis and treatment. Currently, fluorogenic chemical probes are widely used to detect cancer‐associated proteins and their binding partners. These probes are also applicable in photodynamic therapy to determine drug efficacy and monitor regulating factors. In this review, we discuss the synthesis of chemical probes for different cancer types from 2016 to the present time and their application in monitoring the activity of transferases, hydrolases, deacetylases, oxidoreductases, and immune cells. Moreover, we elaborate on their potential roles in photodynamic therapy.
AB - Chemical probes can be used to understand the complex biological nature of diseases. Due to the diversity of cancer types and dynamic regulatory pathways involved in the disease, there is a need to identify signaling pathways and associated proteins or enzymes that are traceable or detectable in tests for cancer diagnosis and treatment. Currently, fluorogenic chemical probes are widely used to detect cancer‐associated proteins and their binding partners. These probes are also applicable in photodynamic therapy to determine drug efficacy and monitor regulating factors. In this review, we discuss the synthesis of chemical probes for different cancer types from 2016 to the present time and their application in monitoring the activity of transferases, hydrolases, deacetylases, oxidoreductases, and immune cells. Moreover, we elaborate on their potential roles in photodynamic therapy.
KW - activity‐based probe
KW - near‐infrared probe
KW - photodynamic therapy
UR - http://www.scopus.com/inward/record.url?scp=85131707552&partnerID=8YFLogxK
U2 - 10.3390/ijms23115936
DO - 10.3390/ijms23115936
M3 - Review article
C2 - 35682614
AN - SCOPUS:85131707552
SN - 1661-6596
VL - 23
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 11
M1 - 5936
ER -
