Chemiluminescence-generating nanoreactor formulation for near-infrared imaging of hydrogen peroxide and glucose level in vivo

Chang Keun Lim, Yong Deok Lee, Jinhee Na, Jung Min Oh, Song Her, Kwang Meyung Kim, Kuiwon Choi, Sehoon Kim, Ick Chan Kwon

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Water-dispersed all-in-one nanoprobes composed of densely integrated peroxyoxalate fuel and a cyanine dye are formulated to optimize the nanoscopic chemiluminescence reaction. It is demonstrated that the chemiluminescent nanoformulation can generate bright near-infrared signal in response to external hydrogen peroxide that is biologically implicated with cell signaling and diseases. Successful imaging of endogenously overproduces hydrogen peroxide and indirect determination of glucose level in vivo with the chemiluminescent nanoprobes offers an opportunity for early diagnosis of diseases.

Original languageEnglish
Pages (from-to)2644-2648
Number of pages5
JournalAdvanced Functional Materials
Volume20
Issue number16
DOIs
Publication statusPublished - 2010 Aug 23
Externally publishedYes

ASJC Scopus subject areas

  • Biomaterials
  • Electrochemistry
  • Condensed Matter Physics
  • Electronic, Optical and Magnetic Materials

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