Chemoenzymatic synthesis of spinosyn A

Hak Joong Kim, Sei Hyun Choi, Byung Sun Jeon, Namho Kim, Rongson Pongdee, Qingquan Wu, Hung Wen Liu

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Following the biosynthesis of polyketide backbones by polyketide synthases (PKSs), post-PKS modifications result in a significantly elevated level of structural complexity that renders the chemical synthesis of these natural products challenging. We report herein a total synthesis of the widely used polyketide insecticide spinosyn A by exploiting the prowess of both chemical and enzymatic methods. As more polyketide biosynthetic pathways are characterized, this chemoenzymatic approach is expected to become readily adaptable to streamlining the synthesis of other complex polyketides with more elaborate post-PKS modifications.

Original languageEnglish
Pages (from-to)13553-13557
Number of pages5
JournalAngewandte Chemie - International Edition
Volume53
Issue number49
DOIs
Publication statusPublished - 2014 Dec 1

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Polyketides
Polyketide Synthases
Insecticides
Biosynthesis
Biological Products
spinosyn A

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Kim, H. J., Choi, S. H., Jeon, B. S., Kim, N., Pongdee, R., Wu, Q., & Liu, H. W. (2014). Chemoenzymatic synthesis of spinosyn A. Angewandte Chemie - International Edition, 53(49), 13553-13557. https://doi.org/10.1002/anie.201407806

Chemoenzymatic synthesis of spinosyn A. / Kim, Hak Joong; Choi, Sei Hyun; Jeon, Byung Sun; Kim, Namho; Pongdee, Rongson; Wu, Qingquan; Liu, Hung Wen.

In: Angewandte Chemie - International Edition, Vol. 53, No. 49, 01.12.2014, p. 13553-13557.

Research output: Contribution to journalArticle

Kim, HJ, Choi, SH, Jeon, BS, Kim, N, Pongdee, R, Wu, Q & Liu, HW 2014, 'Chemoenzymatic synthesis of spinosyn A', Angewandte Chemie - International Edition, vol. 53, no. 49, pp. 13553-13557. https://doi.org/10.1002/anie.201407806
Kim HJ, Choi SH, Jeon BS, Kim N, Pongdee R, Wu Q et al. Chemoenzymatic synthesis of spinosyn A. Angewandte Chemie - International Edition. 2014 Dec 1;53(49):13553-13557. https://doi.org/10.1002/anie.201407806
Kim, Hak Joong ; Choi, Sei Hyun ; Jeon, Byung Sun ; Kim, Namho ; Pongdee, Rongson ; Wu, Qingquan ; Liu, Hung Wen. / Chemoenzymatic synthesis of spinosyn A. In: Angewandte Chemie - International Edition. 2014 ; Vol. 53, No. 49. pp. 13553-13557.
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