Following the biosynthesis of polyketide backbones by polyketide synthases (PKSs), post-PKS modifications result in a significantly elevated level of structural complexity that renders the chemical synthesis of these natural products challenging. We report herein a total synthesis of the widely used polyketide insecticide spinosyn A by exploiting the prowess of both chemical and enzymatic methods. As more polyketide biosynthetic pathways are characterized, this chemoenzymatic approach is expected to become readily adaptable to streamlining the synthesis of other complex polyketides with more elaborate post-PKS modifications.
|Number of pages||5|
|Journal||Angewandte Chemie - International Edition|
|Publication status||Published - 2014 Dec 1|
- Polyketide macrolides
- Post-polyketide synthase modifications
- Total synthesis
ASJC Scopus subject areas