Chemokinrezeptor 5-Δ32-Polymorphismus und systemischer Lupus erythematosus, Vaskulitis sowie Sjögren-Syndrom: Eine Metaanalyse möglicher Zusammenhänge

Translated title of the contribution: Chemokine receptor 5 Δ32 polymorphism and systemic lupus erythematosus, vasculitis, and primary Sjogren’s syndrome: Meta-analysis of possible associations

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Abstract

Results: A total of 12 studies were analyzed, including 5 on SLE, 5 on vasculitis, and 2 on pSS, encompassing 1881 patients and 2391 controls. Meta-analysis indicated no association between SLE and the CCR5-Δ32 allele (OR 0.842, 95 % CI 0.793–1.804, p = 0.657), and no association between the CCR5-Δ32 allele and SLE in Europeans (OR 0.647, 95 % CI 0.306–1.368, p = 0.255). Meta-analysis of the CCR5-Δ32 allele and the Δ32Δ32 + Δ32 W genotype showed no association with lupus nephritis (LN; OR 1.771, 95 % CI 0.475–6.595, p = 0.395; OR 2.192, 95 % CI 0.182–26.42, p = 0.537, respectively). In addition, meta-analysis revealed no association between the CCR5-Δ32 allele and vasculitis in all study subjects and in Europeans (OR 1.241, 95 % CI 0.951–1.620, p = 0.111; OR 1.359, 95 % CI 0.803–2.303, p = 0.254, respectively). However, the overall OR for the CCR5-Δ32 allele was significantly higher in Kawasaki disease (KD; OR 1.746, 95 % CI 1.003–2.955, p = 0.038) and the meta-analysis of the Δ32Δ32 + Δ32 W genotype showed a trend indicating an association with KD (OR 1.683, 95 % CI 0.921–3.077, p = 0.091). No association was found between the CCR5-Δ32 polymorphism and pSS.

Objective: The aim of this study was to determine whether the functional chemokine receptor 5 delta32 (CCR5-Δ32) polymorphism is associated with susceptibility to systemic lupus erythematosus (SLE), vasculitis, and primary Sjogren’s syndrome (pSS).

Conclusion: This meta-analysis demonstrates that the CCR5-Δ32 polymorphism is associated with KD, but does not facilitate susceptibility to SLE, LN, or pSS.

Original languageGerman
Pages (from-to)848-855
Number of pages8
JournalZeitschrift fur Rheumatologie
Volume73
Issue number9
DOIs
Publication statusPublished - 2014 Jan 1

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Keywords

  • Autoimmune diseases
  • Disease susceptibility
  • Genetic polymorphisms
  • Mucocutaneous lymph node syndrome
  • Publication bias

ASJC Scopus subject areas

  • Rheumatology

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