Chemokinrezeptor 5-Δ32-Polymorphismus und systemischer Lupus erythematosus, Vaskulitis sowie Sjögren-Syndrom: Eine Metaanalyse möglicher Zusammenhänge

Young Ho Lee; J. H. Kim; Gwan Gyu Song

doi:10.1007/s00393-014-1356-5

Chemokinrezeptor 5-Δ32-Polymorphismus und systemischer Lupus erythematosus, Vaskulitis sowie Sjögren-Syndrom: Eine Metaanalyse möglicher Zusammenhänge

Translated title of the contribution: Chemokine receptor 5 Δ32 polymorphism and systemic lupus erythematosus, vasculitis, and primary Sjogren’s syndrome: Meta-analysis of possible associations

Young Ho Lee, J. H. Kim, Gwan Gyu Song

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Results: A total of 12 studies were analyzed, including 5 on SLE, 5 on vasculitis, and 2 on pSS, encompassing 1881 patients and 2391 controls. Meta-analysis indicated no association between SLE and the CCR5-Δ32 allele (OR 0.842, 95 % CI 0.793–1.804, p = 0.657), and no association between the CCR5-Δ32 allele and SLE in Europeans (OR 0.647, 95 % CI 0.306–1.368, p = 0.255). Meta-analysis of the CCR5-Δ32 allele and the Δ32Δ32 + Δ32 W genotype showed no association with lupus nephritis (LN; OR 1.771, 95 % CI 0.475–6.595, p = 0.395; OR 2.192, 95 % CI 0.182–26.42, p = 0.537, respectively). In addition, meta-analysis revealed no association between the CCR5-Δ32 allele and vasculitis in all study subjects and in Europeans (OR 1.241, 95 % CI 0.951–1.620, p = 0.111; OR 1.359, 95 % CI 0.803–2.303, p = 0.254, respectively). However, the overall OR for the CCR5-Δ32 allele was significantly higher in Kawasaki disease (KD; OR 1.746, 95 % CI 1.003–2.955, p = 0.038) and the meta-analysis of the Δ32Δ32 + Δ32 W genotype showed a trend indicating an association with KD (OR 1.683, 95 % CI 0.921–3.077, p = 0.091). No association was found between the CCR5-Δ32 polymorphism and pSS.

Objective: The aim of this study was to determine whether the functional chemokine receptor 5 delta32 (CCR5-Δ32) polymorphism is associated with susceptibility to systemic lupus erythematosus (SLE), vasculitis, and primary Sjogren’s syndrome (pSS).

Conclusion: This meta-analysis demonstrates that the CCR5-Δ32 polymorphism is associated with KD, but does not facilitate susceptibility to SLE, LN, or pSS.

Translated title of the contribution	Chemokine receptor 5 Δ32 polymorphism and systemic lupus erythematosus, vasculitis, and primary Sjogren’s syndrome: Meta-analysis of possible associations
Original language	German
Pages (from-to)	848-855
Number of pages	8
Journal	Zeitschrift fur Rheumatologie
Volume	73
Issue number	9
DOIs	https://doi.org/10.1007/s00393-014-1356-5
Publication status	Published - 2014 Nov 1

Keywords

Autoimmune diseases
Disease susceptibility
Genetic polymorphisms
Mucocutaneous lymph node syndrome
Publication bias

ASJC Scopus subject areas

Rheumatology

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10.1007/s00393-014-1356-5

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@article{9f8a416c2bdc4cc99b84623081d344a9,

title = "Chemokinrezeptor 5-Δ32-Polymorphismus und systemischer Lupus erythematosus, Vaskulitis sowie Sj{\"o}gren-Syndrom: Eine Metaanalyse m{\"o}glicher Zusammenh{\"a}nge",

abstract = "Results: A total of 12 studies were analyzed, including 5 on SLE, 5 on vasculitis, and 2 on pSS, encompassing 1881 patients and 2391 controls. Meta-analysis indicated no association between SLE and the CCR5-Δ32 allele (OR 0.842, 95 % CI 0.793–1.804, p = 0.657), and no association between the CCR5-Δ32 allele and SLE in Europeans (OR 0.647, 95 % CI 0.306–1.368, p = 0.255). Meta-analysis of the CCR5-Δ32 allele and the Δ32Δ32 + Δ32 W genotype showed no association with lupus nephritis (LN; OR 1.771, 95 % CI 0.475–6.595, p = 0.395; OR 2.192, 95 % CI 0.182–26.42, p = 0.537, respectively). In addition, meta-analysis revealed no association between the CCR5-Δ32 allele and vasculitis in all study subjects and in Europeans (OR 1.241, 95 % CI 0.951–1.620, p = 0.111; OR 1.359, 95 % CI 0.803–2.303, p = 0.254, respectively). However, the overall OR for the CCR5-Δ32 allele was significantly higher in Kawasaki disease (KD; OR 1.746, 95 % CI 1.003–2.955, p = 0.038) and the meta-analysis of the Δ32Δ32 + Δ32 W genotype showed a trend indicating an association with KD (OR 1.683, 95 % CI 0.921–3.077, p = 0.091). No association was found between the CCR5-Δ32 polymorphism and pSS.Objective: The aim of this study was to determine whether the functional chemokine receptor 5 delta32 (CCR5-Δ32) polymorphism is associated with susceptibility to systemic lupus erythematosus (SLE), vasculitis, and primary Sjogren{\textquoteright}s syndrome (pSS).Conclusion: This meta-analysis demonstrates that the CCR5-Δ32 polymorphism is associated with KD, but does not facilitate susceptibility to SLE, LN, or pSS.",

keywords = "Autoimmune diseases, Disease susceptibility, Genetic polymorphisms, Mucocutaneous lymph node syndrome, Publication bias",

author = "Lee, {Young Ho} and Kim, {J. H.} and Song, {Gwan Gyu}",

year = "2014",

month = nov,

day = "1",

doi = "10.1007/s00393-014-1356-5",

language = "German",

volume = "73",

pages = "848--855",

journal = "Zeitschrift fur Rheumatologie",

issn = "0340-1855",

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T1 - Chemokinrezeptor 5-Δ32-Polymorphismus und systemischer Lupus erythematosus, Vaskulitis sowie Sjögren-Syndrom

T2 - Eine Metaanalyse möglicher Zusammenhänge

AU - Lee, Young Ho

AU - Kim, J. H.

AU - Song, Gwan Gyu

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Results: A total of 12 studies were analyzed, including 5 on SLE, 5 on vasculitis, and 2 on pSS, encompassing 1881 patients and 2391 controls. Meta-analysis indicated no association between SLE and the CCR5-Δ32 allele (OR 0.842, 95 % CI 0.793–1.804, p = 0.657), and no association between the CCR5-Δ32 allele and SLE in Europeans (OR 0.647, 95 % CI 0.306–1.368, p = 0.255). Meta-analysis of the CCR5-Δ32 allele and the Δ32Δ32 + Δ32 W genotype showed no association with lupus nephritis (LN; OR 1.771, 95 % CI 0.475–6.595, p = 0.395; OR 2.192, 95 % CI 0.182–26.42, p = 0.537, respectively). In addition, meta-analysis revealed no association between the CCR5-Δ32 allele and vasculitis in all study subjects and in Europeans (OR 1.241, 95 % CI 0.951–1.620, p = 0.111; OR 1.359, 95 % CI 0.803–2.303, p = 0.254, respectively). However, the overall OR for the CCR5-Δ32 allele was significantly higher in Kawasaki disease (KD; OR 1.746, 95 % CI 1.003–2.955, p = 0.038) and the meta-analysis of the Δ32Δ32 + Δ32 W genotype showed a trend indicating an association with KD (OR 1.683, 95 % CI 0.921–3.077, p = 0.091). No association was found between the CCR5-Δ32 polymorphism and pSS.Objective: The aim of this study was to determine whether the functional chemokine receptor 5 delta32 (CCR5-Δ32) polymorphism is associated with susceptibility to systemic lupus erythematosus (SLE), vasculitis, and primary Sjogren’s syndrome (pSS).Conclusion: This meta-analysis demonstrates that the CCR5-Δ32 polymorphism is associated with KD, but does not facilitate susceptibility to SLE, LN, or pSS.

AB - Results: A total of 12 studies were analyzed, including 5 on SLE, 5 on vasculitis, and 2 on pSS, encompassing 1881 patients and 2391 controls. Meta-analysis indicated no association between SLE and the CCR5-Δ32 allele (OR 0.842, 95 % CI 0.793–1.804, p = 0.657), and no association between the CCR5-Δ32 allele and SLE in Europeans (OR 0.647, 95 % CI 0.306–1.368, p = 0.255). Meta-analysis of the CCR5-Δ32 allele and the Δ32Δ32 + Δ32 W genotype showed no association with lupus nephritis (LN; OR 1.771, 95 % CI 0.475–6.595, p = 0.395; OR 2.192, 95 % CI 0.182–26.42, p = 0.537, respectively). In addition, meta-analysis revealed no association between the CCR5-Δ32 allele and vasculitis in all study subjects and in Europeans (OR 1.241, 95 % CI 0.951–1.620, p = 0.111; OR 1.359, 95 % CI 0.803–2.303, p = 0.254, respectively). However, the overall OR for the CCR5-Δ32 allele was significantly higher in Kawasaki disease (KD; OR 1.746, 95 % CI 1.003–2.955, p = 0.038) and the meta-analysis of the Δ32Δ32 + Δ32 W genotype showed a trend indicating an association with KD (OR 1.683, 95 % CI 0.921–3.077, p = 0.091). No association was found between the CCR5-Δ32 polymorphism and pSS.Objective: The aim of this study was to determine whether the functional chemokine receptor 5 delta32 (CCR5-Δ32) polymorphism is associated with susceptibility to systemic lupus erythematosus (SLE), vasculitis, and primary Sjogren’s syndrome (pSS).Conclusion: This meta-analysis demonstrates that the CCR5-Δ32 polymorphism is associated with KD, but does not facilitate susceptibility to SLE, LN, or pSS.

KW - Autoimmune diseases

KW - Disease susceptibility

KW - Genetic polymorphisms

KW - Mucocutaneous lymph node syndrome

KW - Publication bias

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Chemokinrezeptor 5-Δ32-Polymorphismus und systemischer Lupus erythematosus, Vaskulitis sowie Sjögren-Syndrom: Eine Metaanalyse möglicher Zusammenhänge

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