Chemotherapy for advanced gastric cancer: Review and update of current practices

Sung Chul Park, Hoon-Jai Chun

Research output: Contribution to journalReview article

40 Citations (Scopus)

Abstract

No standard adjuvant or palliative chemotherapy regimen has been internationally approved for patients with advanced gastric cancer. Adjuvant chemoradiotherapy is administered prior to surgery and is used in the Unitied States, and intensified chemotherapy is administered prior to and after surgery and is used in Europe. Limited D1 dissections are also frequently performed in the United States and Europe. In Korea, patients undergoing D2 resection appear to benefit from postoperative adjuvant chemotherapy using S-1 or capecitabine plus oxaliplatin. Fluoropyrimidine, platinum, taxane, epirubicin, and irinotecan may be employed alone or in combination as a first-line therapy in a palliative chemotherapy regimen. In Asia, an orally administered fluoropyrimidine, such as capecitabine or S-1, is favored over the continuous infusion of 5-fluorouracil because of its convenience. Trastuzumab has been integrated into the current standard chemotherapy for human epidermal growth factor receptor 2-overexpressing gastric cancers. There is currently no standard regimen for secondary palliative chemotherapy. Clinical studies of several targeted therapies are ongoing.

Original languageEnglish
Pages (from-to)385-393
Number of pages9
JournalGut and Liver
Volume7
Issue number4
DOIs
Publication statusPublished - 2013 Jul 1

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Keywords

  • Drug therapy
  • Stomach neoplasms

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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