Chitosan dosage regimen to trap fecal oil excretion after peroral lipase inhibitor administration in mice

Yura Jang, Young Tae Je, Cheol-Won Yun, Hesson Chung

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

This study was designed to investigate the oil entrapment and systemic oil absorption-reducing activities of chitosan. High-molecular-weight chitosan formed gel aggregates with oil and bile salts in vitro. The oil/chitosan ratio and the molecular weight of chitosan were optimized for the in vivo study, and a molecular weight >100,000 was effective in reducing the oil contamination of mouse fur. The oil/chitosan weight ratio required for effective oil entrapment was less than 13 and 5 in the in vitro and in vivo experiments, respectively. Chitosan administration was most effective during meals, and high-molecular-weight chitosan could trap and facilitate the reduction of systemic absorption of oil droplets separated by orlistat. The activity of the lipase inhibitor was not altered by chitosan as evidenced by thin layer chromatography, and orlistat was not absorbed systemically by the co-administration of chitosan.

Original languageEnglish
Pages (from-to)484-491
Number of pages8
JournalInternational Journal of Biological Macromolecules
Volume94
DOIs
Publication statusPublished - 2017 Jan 1

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Keywords

  • Chitosan
  • Lipase inhibitor
  • Oil entrapment

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology

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