Chitosan microparticle preparation for controlled drug release by response surface methodology

J. A. Ko, Hyun Jin Park, Y. S. Park, S. J. Hwang, J. B. Park

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The objectives were to investigate the effects of formulation variables on the release of drug and to optimize the formulation of chitosan microparticles loaded with drug for controlled release using response surface methodology. Chitosan microparticles were prepared by dropping a chitosan solution into sodium tripolyphosphate (TPP) through ionic cross-linking. The release behaviour of felodipine as a model drug was affected by preparation variables. A central composite design was used to evaluate and optimize the effect of preparation variables, chitosan concentration (X1), the pH of the TPP solution (X2) and cross-linking time (X3) on the cumulative per cent drug release (Y) in 24 h. Chitosan concentration and cross-linking time affected negatively the release of felodipine, while the pH of the TPP did so positively and was the highest influential factor. The optimum rate of drug release, 100% in 24 h, was achieved at 1.8% chitosan concentration, a pH 8.7 for the TPP solution and 9.7 min cross-linking time.

Original languageEnglish
Pages (from-to)791-797
Number of pages7
JournalJournal of Microencapsulation
Volume20
Issue number6
DOIs
Publication statusPublished - 2003 Nov 1

Fingerprint

Chitosan
microparticles
drugs
methodology
preparation
Pharmaceutical Preparations
Felodipine
formulations
sodium
Drug Liberation
Sodium
composite materials
triphosphoric acid
Composite materials

Keywords

  • Chitosan
  • Drug-delivery system
  • Microparticle
  • Response surface methodology

ASJC Scopus subject areas

  • Chemistry (miscellaneous)
  • Pharmaceutical Science
  • Chemical Engineering(all)
  • Pharmacology

Cite this

Chitosan microparticle preparation for controlled drug release by response surface methodology. / Ko, J. A.; Park, Hyun Jin; Park, Y. S.; Hwang, S. J.; Park, J. B.

In: Journal of Microencapsulation, Vol. 20, No. 6, 01.11.2003, p. 791-797.

Research output: Contribution to journalArticle

Ko, J. A. ; Park, Hyun Jin ; Park, Y. S. ; Hwang, S. J. ; Park, J. B. / Chitosan microparticle preparation for controlled drug release by response surface methodology. In: Journal of Microencapsulation. 2003 ; Vol. 20, No. 6. pp. 791-797.
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