Cholinergic transmission in the dorsal hippocampus modulates trace but not delay fear conditioning

Min Hee Pang, Nam Soo Kim, Il Hwan Kim, Hyun Kim, Hyun Taek Kim, June Seek Choi

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Although cholinergic mechanisms have been widely implicated in learning and memory processes, few studies have investigated the specific contribution of hippocampal cholinergic transmission during trace fear conditioning, a form of associative learning involving a temporal gap between two stimuli. Microinfusions of scopolamine, a muscarinic receptor antagonist, into the dorsal hippocampus (DH) produced dose-dependent impairment in the acquisition and expression of a conditioned response (CR) following trace fear conditioning with a tone conditioned stimulus (CS) and a footshock unconditioned stimulus (US) in rats. The same infusions, however, had no effect on delay conditioning, general activity, pain sensitivity or attentional modulation. Moreover, scopolamine infusions attenuated phosphorylation of extracellular signal-regulated kinase (ERK) in the amygdala, indicating that cholinergic signals in the DH are important for trace fear conditioning. Taken together, the current study provides evidence that cholinergic neurotransmission in the DH is essential for the cellular processing of CS-US association in the amygdala when the two stimuli are temporally disconnected.

Original languageEnglish
Pages (from-to)206-213
Number of pages8
JournalNeurobiology of Learning and Memory
Volume94
Issue number2
DOIs
Publication statusPublished - 2010 Sep 1

Fingerprint

Cholinergic Agents
Fear
Hippocampus
Scopolamine Hydrobromide
Amygdala
Learning
Muscarinic Antagonists
Extracellular Signal-Regulated MAP Kinases
Muscarinic Receptors
Synaptic Transmission
Phosphorylation
Pain
Conditioning (Psychology)

Keywords

  • Cholinergic system
  • ERK
  • Hippocampus
  • Scopolamine
  • Trace fear conditioning

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology

Cite this

Cholinergic transmission in the dorsal hippocampus modulates trace but not delay fear conditioning. / Pang, Min Hee; Kim, Nam Soo; Kim, Il Hwan; Kim, Hyun; Kim, Hyun Taek; Choi, June Seek.

In: Neurobiology of Learning and Memory, Vol. 94, No. 2, 01.09.2010, p. 206-213.

Research output: Contribution to journalArticle

Pang, Min Hee ; Kim, Nam Soo ; Kim, Il Hwan ; Kim, Hyun ; Kim, Hyun Taek ; Choi, June Seek. / Cholinergic transmission in the dorsal hippocampus modulates trace but not delay fear conditioning. In: Neurobiology of Learning and Memory. 2010 ; Vol. 94, No. 2. pp. 206-213.
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