Chorea due to diabetic hyperglycemia and uremia: Distinct clinical and imaging features

Young Jin Kim, Sang Joon Kim, Juyeon Kim, Mi Jung Kim, Ki Ju Kim, Hyukjun Yoon, Sung Reul Kim, Sun Ju Chung

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


This study was undertaken to describe the clinical and imaging characteristics of patients with chorea associated with nonketotic hyperglycemia (C-NKH) in comparison with patients with chorea associated with uremia (C-URE). We retrospectively analyzed the clinical data of consecutive 10 C-NKH and five C-URE patients who were treated between January 1, 2001 and January 31, 2013. Women were more frequently affected by C-NKH (70% vs. 30%) and C-URE (80% vs. 20%) compared with men. The C-NKH patients demonstrated T1-hyperintense and inhomogeneous lesions in the basal ganglia, whereas C-URE patients demonstrated T2-hyperintense and homogeneous lesions in the basal ganglia. The mean time for chorea resolution after treatment was significantly shorter in C-NKH patients than in C-URE patients (4.4±2.6 d vs. 73.8±14.2 d, respectively; P=0.005). The clinical and imaging features are remarkably different between C-NKH and C-URE patients, suggesting distinct pathogenic mechanisms.

Original languageEnglish
Pages (from-to)419-422
Number of pages4
JournalMovement Disorders
Issue number3
Publication statusPublished - 2015 Mar 1
Externally publishedYes


  • Chorea
  • Diabetes
  • Hyperglycemia
  • Magnetic resonance imaging
  • Uremia

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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