Chromofluorescent indicator for intracellular Zn2+/Hg 2+ dynamic exchange

Jeong Won Lee, Hyo Sung Jung, Pil Seung Kwon, Jong Wan Kim, Richard A. Bartsch, Youngmee Kim, Sung Jin Kim, Jong Seung Kim

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

(Chemical Equation Presented) (Figure Presented) The fluorescence of NABQ increases remarkably in the presence of Zn2+ and is quenched by Hg2+. As shown by confocal imaging, NABQ-Zn2+ can penetrate cells, where the bound Zn2+ is exchanged for Hg 2+. This results in the concomitant export of Hg2+ from the cells, showing that NABQ can act as a Zn2+ carrier and as a Hg2+ extracting agent in living cells.

Original languageEnglish
Pages (from-to)3801-3804
Number of pages4
JournalOrganic Letters
Volume10
Issue number17
DOIs
Publication statusPublished - 2008 Dec 1

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

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    Lee, J. W., Jung, H. S., Kwon, P. S., Kim, J. W., Bartsch, R. A., Kim, Y., Kim, S. J., & Kim, J. S. (2008). Chromofluorescent indicator for intracellular Zn2+/Hg 2+ dynamic exchange. Organic Letters, 10(17), 3801-3804. https://doi.org/10.1021/ol801482n