Chromosomal aberrations in Korean nonsmall cell lung carcinomas: Degenerate oligonucleotide primed polymerase chain reaction comparative genomic hybridization studies

Soo Yeun Park, Yeul Hong Kim, Kwang Ho In, Yong Hyuck Chun, Sun-Hwa Park

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5 Citations (Scopus)

Abstract

Chromosomal aberrations were investigated in 48 Korean nonsmall cell carcinomas of the lung (NSCLC), by degenerate oligonucleotide primed polymerase chain reaction comparative genomic hybridization. These included 16 adenocarcinomas, 27 squamous cell carcinomas (SCCs), and 5 large-cell carcinomas. The common sites of copy number increases were 3q26∼qter (23 cases, 48%); 8q23∼qter (46%); 20q13.1 (42%); 1q42∼qter (38%); 3q25 (38%); 21q22 (38%); and 22q13 (38%). DNA amplification was identified in 19 carcinomas (40%), and the frequent sites of amplification were 8q24 (seven cases), 3q26 (seven cases), and 3q27 (seven cases). The frequently under-represented chromosomal regions were Yq (38%), 4q25∼q26 (23%), and 4q31 (23%). In particular, gains of 3q26∼qter (74%), 15q (56%), and 19q (59%) and loss of 13q22∼q31 (26%) were more frequently detected in SCCs of the lung. These nonrandom aberrations can serve as starting points for the identification of potential oncogenes/tumor suppressor genes related to the tumorigenesis of Korean NSCLC.

Original languageEnglish
Pages (from-to)153-157
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume152
Issue number2
DOIs
Publication statusPublished - 2004 Jul 15

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Comparative Genomic Hybridization
Chromosome Aberrations
Carcinoma
Polymerase Chain Reaction
Lung
Squamous Cell Carcinoma
Large Cell Carcinoma
Tumor Suppressor Genes
Oncogenes
Carcinogenesis
Adenocarcinoma
DNA
ribonucleotide polymerase

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

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title = "Chromosomal aberrations in Korean nonsmall cell lung carcinomas: Degenerate oligonucleotide primed polymerase chain reaction comparative genomic hybridization studies",
abstract = "Chromosomal aberrations were investigated in 48 Korean nonsmall cell carcinomas of the lung (NSCLC), by degenerate oligonucleotide primed polymerase chain reaction comparative genomic hybridization. These included 16 adenocarcinomas, 27 squamous cell carcinomas (SCCs), and 5 large-cell carcinomas. The common sites of copy number increases were 3q26∼qter (23 cases, 48{\%}); 8q23∼qter (46{\%}); 20q13.1 (42{\%}); 1q42∼qter (38{\%}); 3q25 (38{\%}); 21q22 (38{\%}); and 22q13 (38{\%}). DNA amplification was identified in 19 carcinomas (40{\%}), and the frequent sites of amplification were 8q24 (seven cases), 3q26 (seven cases), and 3q27 (seven cases). The frequently under-represented chromosomal regions were Yq (38{\%}), 4q25∼q26 (23{\%}), and 4q31 (23{\%}). In particular, gains of 3q26∼qter (74{\%}), 15q (56{\%}), and 19q (59{\%}) and loss of 13q22∼q31 (26{\%}) were more frequently detected in SCCs of the lung. These nonrandom aberrations can serve as starting points for the identification of potential oncogenes/tumor suppressor genes related to the tumorigenesis of Korean NSCLC.",
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AU - Chun, Yong Hyuck

AU - Park, Sun-Hwa

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AB - Chromosomal aberrations were investigated in 48 Korean nonsmall cell carcinomas of the lung (NSCLC), by degenerate oligonucleotide primed polymerase chain reaction comparative genomic hybridization. These included 16 adenocarcinomas, 27 squamous cell carcinomas (SCCs), and 5 large-cell carcinomas. The common sites of copy number increases were 3q26∼qter (23 cases, 48%); 8q23∼qter (46%); 20q13.1 (42%); 1q42∼qter (38%); 3q25 (38%); 21q22 (38%); and 22q13 (38%). DNA amplification was identified in 19 carcinomas (40%), and the frequent sites of amplification were 8q24 (seven cases), 3q26 (seven cases), and 3q27 (seven cases). The frequently under-represented chromosomal regions were Yq (38%), 4q25∼q26 (23%), and 4q31 (23%). In particular, gains of 3q26∼qter (74%), 15q (56%), and 19q (59%) and loss of 13q22∼q31 (26%) were more frequently detected in SCCs of the lung. These nonrandom aberrations can serve as starting points for the identification of potential oncogenes/tumor suppressor genes related to the tumorigenesis of Korean NSCLC.

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