TY - JOUR
T1 - Chromosomal imbalances in Korean intrahepatic cholangiocarcinoma by comparative genomic hybridization
AU - Uhm, Kyung Ok
AU - Park, Young Nyun
AU - Lee, Ji Young
AU - Yoon, Dong Seop
AU - Park, Sun Hwa
N1 - Funding Information:
This work was supported by a grant from the Medical Science Research Center, Korea University, the Brain Korea 21 Project, and grant no. R04-2000-000-00047-0 from the Basic Research Program of the Korea Science and Engineering Foundation.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2005/2
Y1 - 2005/2
N2 - Intrahepatic cholangiocarcinoma (ICC) arises from epithelial cells in the intrahepatic bile duct. Until now, only few reports have been available concerning the genetic changes during the progression of ICC. In this study, we analyzed chromosomal aberrations in 19 frozen ICC samples using comparative genomic hybridization. The common chromosomal gains were observed in 8q22∼qter (11 cases, 58%), 5p14∼pter (32%), 2q33∼qter (26%), 7p (26%), 17q21∼q22 (26%), 18q12∼q21 (26%), and 19q13.1 (26%). DNA amplification was identified in nine tumors (47%). Chromosomal loss was found in Y (60%), 1p34∼pter (37%), 4q(32%), 18q21∼qter (32%) 19p (32%), X (32%), 5q11∼q14 (26%), 8p(26%), 9p (26%), and 17p (26%). Chromosomal aberrations identified in this study provide candidate regions involved in the tumorigenesis and progression of ICC.
AB - Intrahepatic cholangiocarcinoma (ICC) arises from epithelial cells in the intrahepatic bile duct. Until now, only few reports have been available concerning the genetic changes during the progression of ICC. In this study, we analyzed chromosomal aberrations in 19 frozen ICC samples using comparative genomic hybridization. The common chromosomal gains were observed in 8q22∼qter (11 cases, 58%), 5p14∼pter (32%), 2q33∼qter (26%), 7p (26%), 17q21∼q22 (26%), 18q12∼q21 (26%), and 19q13.1 (26%). DNA amplification was identified in nine tumors (47%). Chromosomal loss was found in Y (60%), 1p34∼pter (37%), 4q(32%), 18q21∼qter (32%) 19p (32%), X (32%), 5q11∼q14 (26%), 8p(26%), 9p (26%), and 17p (26%). Chromosomal aberrations identified in this study provide candidate regions involved in the tumorigenesis and progression of ICC.
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U2 - 10.1016/j.cancergencyto.2004.05.007
DO - 10.1016/j.cancergencyto.2004.05.007
M3 - Article
C2 - 15676145
AN - SCOPUS:12844271146
VL - 157
SP - 37
EP - 41
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 1
ER -
