Chromosomal imbalances in Korean intrahepatic cholangiocarcinoma by comparative genomic hybridization

Kyung Ok Uhm, Young Nyun Park, Ji Young Lee, Dong Seop Yoon, Sun-Hwa Park

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Intrahepatic cholangiocarcinoma (ICC) arises from epithelial cells in the intrahepatic bile duct. Until now, only few reports have been available concerning the genetic changes during the progression of ICC. In this study, we analyzed chromosomal aberrations in 19 frozen ICC samples using comparative genomic hybridization. The common chromosomal gains were observed in 8q22∼qter (11 cases, 58%), 5p14∼pter (32%), 2q33∼qter (26%), 7p (26%), 17q21∼q22 (26%), 18q12∼q21 (26%), and 19q13.1 (26%). DNA amplification was identified in nine tumors (47%). Chromosomal loss was found in Y (60%), 1p34∼pter (37%), 4q(32%), 18q21∼qter (32%) 19p (32%), X (32%), 5q11∼q14 (26%), 8p(26%), 9p (26%), and 17p (26%). Chromosomal aberrations identified in this study provide candidate regions involved in the tumorigenesis and progression of ICC.

Original languageEnglish
Pages (from-to)37-41
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume157
Issue number1
DOIs
Publication statusPublished - 2005 Feb 1
Externally publishedYes

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Comparative Genomic Hybridization
Cholangiocarcinoma
Chromosome Aberrations
Intrahepatic Bile Ducts
Carcinogenesis
Epithelial Cells
DNA
Neoplasms

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Chromosomal imbalances in Korean intrahepatic cholangiocarcinoma by comparative genomic hybridization. / Uhm, Kyung Ok; Park, Young Nyun; Lee, Ji Young; Yoon, Dong Seop; Park, Sun-Hwa.

In: Cancer Genetics and Cytogenetics, Vol. 157, No. 1, 01.02.2005, p. 37-41.

Research output: Contribution to journalArticle

Uhm, Kyung Ok ; Park, Young Nyun ; Lee, Ji Young ; Yoon, Dong Seop ; Park, Sun-Hwa. / Chromosomal imbalances in Korean intrahepatic cholangiocarcinoma by comparative genomic hybridization. In: Cancer Genetics and Cytogenetics. 2005 ; Vol. 157, No. 1. pp. 37-41.
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