Chronic brain inflammation impairs two forms of long-term potentiation in the rat hippocampal CA1 area

Sun Seek Min, Hui Yan Quan, Jinhua Ma, Jung Soo Han, Byeong Hwa Jeon, Geun Hee Seol

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Neuroinflammation plays an important role in the progression of Alzheimer's disease (AD) and is characterized by the presence of activated microglia. We investigated whether chronic neuroinflammation affects the induction of N-methyl-d-aspartate receptor (NMDAR)-dependent long-term potentiation (LTP) and NMDAR-independent LTP which is expressed by voltage-dependent calcium channel (VDCC). Chronic neuroinflammation was induced by administration of lipopolysaccharide (LPS) (28 days, 0.35 μg/h) to the fourth ventricle. The Morris water maze test was conducted to measure the memory impairment and then excitatory postsynaptic potentials were recorded extracelluarly from stratum radiatum in the rat hippocampal CA1 area to examine the changes in synaptic plasticity induced by LPS infusion. Chronic administration of LPS induced remarkable memory impairment. The field recording experiments revealed that the induction of both NMDAR-dependent LTP and NMDAR-independent LTP were impaired in the hippocampal Schaffer collateral-CA1 synapse in animals chronically infused with LPS. The present results show that chronic neuroinflammation can lead to the impaired spatial memory and attenuation of VDCC-dependent LTP as well as NMDAR-dependent LTP. The attenuation of synaptic plasticity may be caused by the impairment of both NMDAR and L-type Ca2+ via elevated levels of inflammatory proteins, which may underlie aspects of dementia.

Original languageEnglish
Pages (from-to)20-24
Number of pages5
JournalNeuroscience Letters
Volume456
Issue number1
DOIs
Publication statusPublished - 2009 May 29

Fingerprint

Long-Term Potentiation
Encephalitis
Lipopolysaccharides
Neuronal Plasticity
Calcium Channels
Fourth Ventricle
Excitatory Postsynaptic Potentials
Microglia
Synapses
Dementia
aspartic acid receptor
Hippocampus
Alzheimer Disease
Water
Proteins

Keywords

  • Hippocampus
  • Long-term potentiation
  • Memory
  • Neuroinflammation
  • NMDA-dependent LTP
  • VDCC-dependent LTP

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Chronic brain inflammation impairs two forms of long-term potentiation in the rat hippocampal CA1 area. / Min, Sun Seek; Quan, Hui Yan; Ma, Jinhua; Han, Jung Soo; Jeon, Byeong Hwa; Seol, Geun Hee.

In: Neuroscience Letters, Vol. 456, No. 1, 29.05.2009, p. 20-24.

Research output: Contribution to journalArticle

Min, Sun Seek ; Quan, Hui Yan ; Ma, Jinhua ; Han, Jung Soo ; Jeon, Byeong Hwa ; Seol, Geun Hee. / Chronic brain inflammation impairs two forms of long-term potentiation in the rat hippocampal CA1 area. In: Neuroscience Letters. 2009 ; Vol. 456, No. 1. pp. 20-24.
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