Chronic hepatitis B infection is significantly associated with chronic kidney disease: A population-based, matched case-control study

Sung Eun Kim, Eun Sun Jang, Moran Ki, Geum Youn Gwak, Kyung Ah Kim, Gi Ae Kim, Do Young Kim, Dong Joon Kim, Man Woo Kim, Yun Soo Kim, Young Seok Kim, In Hee Kim, Chang Wook Kim, Ho Dong Kim, Hyung Joon Kim, Neung Hwa Park, Soon Koo Baik, Jeong Ill Suh, Byung Cheol Song, Il Han SongJong Eun Yeon, Byung Seok Lee, Youn Jae Lee, Young Kul Jung, Woo Jin Chung, Sung Bum Cho, Eun Young Cho, Hyun Chin Cho, Gab Jin Cheon, Hee Bok Chae, Dae Hee Choi, Sung Kyu Choi, Hwa Young Choi, Won Young Tak, Jeong Heo, Sook Hyang Jeong

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Hepatitis B virus (HBV) infection leads to hepatic and extrahepatic manifestations including chronic kidney disease (CKD). However, the association between HBV and CKD is not clear. This study investigated the association between chronic HBV infection and CKD in a nationwide multicenter study. Methods: A total of 265,086 subjects who underwent health-check examinations in 33 hospitals from January 2015 to December 2015 were enrolled. HBV surface antigen (HBsAg) positive cases (n = 10,048), and age- and gender-matched HBsAg negative controls (n = 40,192) were identified. CKD was defined as a glomerular filtration rate (GFR) < 60 mL/min/1.73 m2 or proteinuria as at least grade 2+ of urine protein. Results: HBsAg positive cases showed a significantly higher prevalence of GFR < 60 mL/min/1.73 m2 (3.3%), and proteinuria (18.9%) than that of the controls (2.6%, P < 0.001, and 14.1%, P < 0.001, respectively). In the multivariate analysis, HBsAg positivity was an independent factor associated with GFR < 60 mL/min/1.73 m2 along with age, blood levels of albumin, bilirubin, anemia, and hemoglobin A1c (HbA1c). Likewise, HBsAg positivity was an independent factor for proteinuria along with age, male, blood levels of bilirubin, protein, albumin, and HbA1c. A subgroup analysis showed that HBsAg positive men but not women had a significantly increased risk for GFR < 60 mL/min/1.73 m2. Conclusion: Chronic HBV infection was significantly associated with a GFR < 60 mL/min/1.73 m2 and proteinuria (≥ 2+). Therefore, clinical concern about CKD in chronic HBV infected patients, especially in male, is warranted.

Original languageEnglish
Article numbere264
JournalJournal of Korean Medical Science
Volume33
Issue number42
DOIs
Publication statusPublished - 2018 Oct 1

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Chronic Hepatitis B
Chronic Renal Insufficiency
Hepatitis B virus
Surface Antigens
Case-Control Studies
Glomerular Filtration Rate
Proteinuria
Virus Diseases
Infection
Population
Bilirubin
Albumins
Hemoglobins
Hepatitis B Surface Antigens
Multicenter Studies
Anemia
Proteins
Multivariate Analysis
Urine
Liver

Keywords

  • Chronic renal insufficiency
  • Glomerular filtration rate
  • Hepatitis B virus
  • Proteinuria

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Chronic hepatitis B infection is significantly associated with chronic kidney disease : A population-based, matched case-control study. / Kim, Sung Eun; Jang, Eun Sun; Ki, Moran; Gwak, Geum Youn; Kim, Kyung Ah; Kim, Gi Ae; Kim, Do Young; Kim, Dong Joon; Kim, Man Woo; Kim, Yun Soo; Kim, Young Seok; Kim, In Hee; Kim, Chang Wook; Kim, Ho Dong; Kim, Hyung Joon; Park, Neung Hwa; Baik, Soon Koo; Suh, Jeong Ill; Song, Byung Cheol; Song, Il Han; Yeon, Jong Eun; Lee, Byung Seok; Lee, Youn Jae; Jung, Young Kul; Chung, Woo Jin; Cho, Sung Bum; Cho, Eun Young; Cho, Hyun Chin; Cheon, Gab Jin; Chae, Hee Bok; Choi, Dae Hee; Choi, Sung Kyu; Choi, Hwa Young; Tak, Won Young; Heo, Jeong; Jeong, Sook Hyang.

In: Journal of Korean Medical Science, Vol. 33, No. 42, e264, 01.10.2018.

Research output: Contribution to journalArticle

Kim, SE, Jang, ES, Ki, M, Gwak, GY, Kim, KA, Kim, GA, Kim, DY, Kim, DJ, Kim, MW, Kim, YS, Kim, YS, Kim, IH, Kim, CW, Kim, HD, Kim, HJ, Park, NH, Baik, SK, Suh, JI, Song, BC, Song, IH, Yeon, JE, Lee, BS, Lee, YJ, Jung, YK, Chung, WJ, Cho, SB, Cho, EY, Cho, HC, Cheon, GJ, Chae, HB, Choi, DH, Choi, SK, Choi, HY, Tak, WY, Heo, J & Jeong, SH 2018, 'Chronic hepatitis B infection is significantly associated with chronic kidney disease: A population-based, matched case-control study', Journal of Korean Medical Science, vol. 33, no. 42, e264. https://doi.org/10.3346/jkms.2018.33.e264
Kim, Sung Eun ; Jang, Eun Sun ; Ki, Moran ; Gwak, Geum Youn ; Kim, Kyung Ah ; Kim, Gi Ae ; Kim, Do Young ; Kim, Dong Joon ; Kim, Man Woo ; Kim, Yun Soo ; Kim, Young Seok ; Kim, In Hee ; Kim, Chang Wook ; Kim, Ho Dong ; Kim, Hyung Joon ; Park, Neung Hwa ; Baik, Soon Koo ; Suh, Jeong Ill ; Song, Byung Cheol ; Song, Il Han ; Yeon, Jong Eun ; Lee, Byung Seok ; Lee, Youn Jae ; Jung, Young Kul ; Chung, Woo Jin ; Cho, Sung Bum ; Cho, Eun Young ; Cho, Hyun Chin ; Cheon, Gab Jin ; Chae, Hee Bok ; Choi, Dae Hee ; Choi, Sung Kyu ; Choi, Hwa Young ; Tak, Won Young ; Heo, Jeong ; Jeong, Sook Hyang. / Chronic hepatitis B infection is significantly associated with chronic kidney disease : A population-based, matched case-control study. In: Journal of Korean Medical Science. 2018 ; Vol. 33, No. 42.
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abstract = "Background: Hepatitis B virus (HBV) infection leads to hepatic and extrahepatic manifestations including chronic kidney disease (CKD). However, the association between HBV and CKD is not clear. This study investigated the association between chronic HBV infection and CKD in a nationwide multicenter study. Methods: A total of 265,086 subjects who underwent health-check examinations in 33 hospitals from January 2015 to December 2015 were enrolled. HBV surface antigen (HBsAg) positive cases (n = 10,048), and age- and gender-matched HBsAg negative controls (n = 40,192) were identified. CKD was defined as a glomerular filtration rate (GFR) < 60 mL/min/1.73 m2 or proteinuria as at least grade 2+ of urine protein. Results: HBsAg positive cases showed a significantly higher prevalence of GFR < 60 mL/min/1.73 m2 (3.3{\%}), and proteinuria (18.9{\%}) than that of the controls (2.6{\%}, P < 0.001, and 14.1{\%}, P < 0.001, respectively). In the multivariate analysis, HBsAg positivity was an independent factor associated with GFR < 60 mL/min/1.73 m2 along with age, blood levels of albumin, bilirubin, anemia, and hemoglobin A1c (HbA1c). Likewise, HBsAg positivity was an independent factor for proteinuria along with age, male, blood levels of bilirubin, protein, albumin, and HbA1c. A subgroup analysis showed that HBsAg positive men but not women had a significantly increased risk for GFR < 60 mL/min/1.73 m2. Conclusion: Chronic HBV infection was significantly associated with a GFR < 60 mL/min/1.73 m2 and proteinuria (≥ 2+). Therefore, clinical concern about CKD in chronic HBV infected patients, especially in male, is warranted.",
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author = "Kim, {Sung Eun} and Jang, {Eun Sun} and Moran Ki and Gwak, {Geum Youn} and Kim, {Kyung Ah} and Kim, {Gi Ae} and Kim, {Do Young} and Kim, {Dong Joon} and Kim, {Man Woo} and Kim, {Yun Soo} and Kim, {Young Seok} and Kim, {In Hee} and Kim, {Chang Wook} and Kim, {Ho Dong} and Kim, {Hyung Joon} and Park, {Neung Hwa} and Baik, {Soon Koo} and Suh, {Jeong Ill} and Song, {Byung Cheol} and Song, {Il Han} and Yeon, {Jong Eun} and Lee, {Byung Seok} and Lee, {Youn Jae} and Jung, {Young Kul} and Chung, {Woo Jin} and Cho, {Sung Bum} and Cho, {Eun Young} and Cho, {Hyun Chin} and Cheon, {Gab Jin} and Chae, {Hee Bok} and Choi, {Dae Hee} and Choi, {Sung Kyu} and Choi, {Hwa Young} and Tak, {Won Young} and Jeong Heo and Jeong, {Sook Hyang}",
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TY - JOUR

T1 - Chronic hepatitis B infection is significantly associated with chronic kidney disease

T2 - A population-based, matched case-control study

AU - Kim, Sung Eun

AU - Jang, Eun Sun

AU - Ki, Moran

AU - Gwak, Geum Youn

AU - Kim, Kyung Ah

AU - Kim, Gi Ae

AU - Kim, Do Young

AU - Kim, Dong Joon

AU - Kim, Man Woo

AU - Kim, Yun Soo

AU - Kim, Young Seok

AU - Kim, In Hee

AU - Kim, Chang Wook

AU - Kim, Ho Dong

AU - Kim, Hyung Joon

AU - Park, Neung Hwa

AU - Baik, Soon Koo

AU - Suh, Jeong Ill

AU - Song, Byung Cheol

AU - Song, Il Han

AU - Yeon, Jong Eun

AU - Lee, Byung Seok

AU - Lee, Youn Jae

AU - Jung, Young Kul

AU - Chung, Woo Jin

AU - Cho, Sung Bum

AU - Cho, Eun Young

AU - Cho, Hyun Chin

AU - Cheon, Gab Jin

AU - Chae, Hee Bok

AU - Choi, Dae Hee

AU - Choi, Sung Kyu

AU - Choi, Hwa Young

AU - Tak, Won Young

AU - Heo, Jeong

AU - Jeong, Sook Hyang

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Background: Hepatitis B virus (HBV) infection leads to hepatic and extrahepatic manifestations including chronic kidney disease (CKD). However, the association between HBV and CKD is not clear. This study investigated the association between chronic HBV infection and CKD in a nationwide multicenter study. Methods: A total of 265,086 subjects who underwent health-check examinations in 33 hospitals from January 2015 to December 2015 were enrolled. HBV surface antigen (HBsAg) positive cases (n = 10,048), and age- and gender-matched HBsAg negative controls (n = 40,192) were identified. CKD was defined as a glomerular filtration rate (GFR) < 60 mL/min/1.73 m2 or proteinuria as at least grade 2+ of urine protein. Results: HBsAg positive cases showed a significantly higher prevalence of GFR < 60 mL/min/1.73 m2 (3.3%), and proteinuria (18.9%) than that of the controls (2.6%, P < 0.001, and 14.1%, P < 0.001, respectively). In the multivariate analysis, HBsAg positivity was an independent factor associated with GFR < 60 mL/min/1.73 m2 along with age, blood levels of albumin, bilirubin, anemia, and hemoglobin A1c (HbA1c). Likewise, HBsAg positivity was an independent factor for proteinuria along with age, male, blood levels of bilirubin, protein, albumin, and HbA1c. A subgroup analysis showed that HBsAg positive men but not women had a significantly increased risk for GFR < 60 mL/min/1.73 m2. Conclusion: Chronic HBV infection was significantly associated with a GFR < 60 mL/min/1.73 m2 and proteinuria (≥ 2+). Therefore, clinical concern about CKD in chronic HBV infected patients, especially in male, is warranted.

AB - Background: Hepatitis B virus (HBV) infection leads to hepatic and extrahepatic manifestations including chronic kidney disease (CKD). However, the association between HBV and CKD is not clear. This study investigated the association between chronic HBV infection and CKD in a nationwide multicenter study. Methods: A total of 265,086 subjects who underwent health-check examinations in 33 hospitals from January 2015 to December 2015 were enrolled. HBV surface antigen (HBsAg) positive cases (n = 10,048), and age- and gender-matched HBsAg negative controls (n = 40,192) were identified. CKD was defined as a glomerular filtration rate (GFR) < 60 mL/min/1.73 m2 or proteinuria as at least grade 2+ of urine protein. Results: HBsAg positive cases showed a significantly higher prevalence of GFR < 60 mL/min/1.73 m2 (3.3%), and proteinuria (18.9%) than that of the controls (2.6%, P < 0.001, and 14.1%, P < 0.001, respectively). In the multivariate analysis, HBsAg positivity was an independent factor associated with GFR < 60 mL/min/1.73 m2 along with age, blood levels of albumin, bilirubin, anemia, and hemoglobin A1c (HbA1c). Likewise, HBsAg positivity was an independent factor for proteinuria along with age, male, blood levels of bilirubin, protein, albumin, and HbA1c. A subgroup analysis showed that HBsAg positive men but not women had a significantly increased risk for GFR < 60 mL/min/1.73 m2. Conclusion: Chronic HBV infection was significantly associated with a GFR < 60 mL/min/1.73 m2 and proteinuria (≥ 2+). Therefore, clinical concern about CKD in chronic HBV infected patients, especially in male, is warranted.

KW - Chronic renal insufficiency

KW - Glomerular filtration rate

KW - Hepatitis B virus

KW - Proteinuria

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U2 - 10.3346/jkms.2018.33.e264

DO - 10.3346/jkms.2018.33.e264

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JO - Journal of Korean Medical Science

JF - Journal of Korean Medical Science

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M1 - e264

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