TY - JOUR
T1 - Chronic medical conditions and metabolic syndrome as risk factors for incidence of major depressive disorder
T2 - A longitudinal study based on 4.7 million adults in South Korea
AU - Han, Kyu Man
AU - Kim, Min Sun
AU - Kim, Aram
AU - Paik, Jong Woo
AU - Lee, Juneyoung
AU - Ham, Byung Joo
N1 - Funding Information:
This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science, ICT & Future Planning ( NRF-2016M3A9A7916996 ) and the Research Program To Solve Social Issues of the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT ( NRF-2017R1A2B4002090 ). The funding agency had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Funding Information:
The authors declare no conflicts of interest. None. This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2016M3A9A7916996) and the Research Program To Solve Social Issues of the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2017R1A2B4002090). The funding agency had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Background: The assessment of comorbid physical illness and metabolic or cardiovascular risk factors as potential risk factors for onset of major depressive disorder (MDD) is crucial. We aimed to investigate potential risk factors for the development of MDD among individuals with chronic medical conditions and metabolic and behavioral risk factors using a large population-based retrospective cohort from the data of the National Health Insurance Service (NHIS) in South Korea. Methods: The population-based retrospective cohort included data from 2,370,815 adults (age ≥20 years) diagnosed with MDD between January 1, 2010, and December 31, 2016 and age- and gender-matched 2,370,815 healthy controls obtained from the claims data of the NHIS. The data of the regular health checkup provided by the NHIS were also included (age ≥40 years). Logistic regression analyses were performed to investigate the potential risk factors for the incidence of MDD. Results: Chronic medical conditions such as Parkinson's disease (odds ratio [OR] = 7.808, 95% confidence interval [CI] = 7.517–8.11), epilepsy (OR = 6.119, 95% CI = 6.019–6.22), multiple sclerosis (OR = 5.532, 95% CI = 4.976–6.151), Huntington's disease (OR = 5.387, 95% CI = 3.258–8.909), migraine (OR = 4.374, 95% CI = 4.341–4.408), stroke (OR = 4.074, 95% CI = 4.032–4.117), and cancer; metabolic syndrome (OR = 1.049, 95% CI = 1.041–1.057) and several of its components including central obesity, elevated fasting blood glucose and triglyceride levels, and reduced high-density lipoprotein level; and cigarette smoking, frequent alcohol consumption, and low physical activity are potential risk factors for the development of MDD. Conclusion: Our results may support previous evidence on the association between physical conditions and the incidence of MDD as reported by individual population-based studies with modest sample sizes.
AB - Background: The assessment of comorbid physical illness and metabolic or cardiovascular risk factors as potential risk factors for onset of major depressive disorder (MDD) is crucial. We aimed to investigate potential risk factors for the development of MDD among individuals with chronic medical conditions and metabolic and behavioral risk factors using a large population-based retrospective cohort from the data of the National Health Insurance Service (NHIS) in South Korea. Methods: The population-based retrospective cohort included data from 2,370,815 adults (age ≥20 years) diagnosed with MDD between January 1, 2010, and December 31, 2016 and age- and gender-matched 2,370,815 healthy controls obtained from the claims data of the NHIS. The data of the regular health checkup provided by the NHIS were also included (age ≥40 years). Logistic regression analyses were performed to investigate the potential risk factors for the incidence of MDD. Results: Chronic medical conditions such as Parkinson's disease (odds ratio [OR] = 7.808, 95% confidence interval [CI] = 7.517–8.11), epilepsy (OR = 6.119, 95% CI = 6.019–6.22), multiple sclerosis (OR = 5.532, 95% CI = 4.976–6.151), Huntington's disease (OR = 5.387, 95% CI = 3.258–8.909), migraine (OR = 4.374, 95% CI = 4.341–4.408), stroke (OR = 4.074, 95% CI = 4.032–4.117), and cancer; metabolic syndrome (OR = 1.049, 95% CI = 1.041–1.057) and several of its components including central obesity, elevated fasting blood glucose and triglyceride levels, and reduced high-density lipoprotein level; and cigarette smoking, frequent alcohol consumption, and low physical activity are potential risk factors for the development of MDD. Conclusion: Our results may support previous evidence on the association between physical conditions and the incidence of MDD as reported by individual population-based studies with modest sample sizes.
KW - Longitudinal
KW - Major depressive disorder
KW - Metabolic syndrome
KW - Physical illness
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=85068877285&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2019.07.003
DO - 10.1016/j.jad.2019.07.003
M3 - Article
C2 - 31319340
AN - SCOPUS:85068877285
VL - 257
SP - 486
EP - 494
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
ER -
