Chronic sleep fragmentation promotes obesity in young adult mice

Yang Wang, Alba Carreras, Seung Hoon Lee, Fahed Hakim, Shelley X. Zhang, Deepti Nair, Honggang Ye, David Gozal

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Objectives Short sleep confers a higher risk of obesity in humans. Restricted sleep increases appetite, promotes higher calorie intake from fat and carbohydrate sources, and induces insulin resistance. However, the effects of fragmented sleep (SF), such as occurs in sleep apnea, on body weight, metabolic rates, and adipose tissue distribution are unknown. Methods C57BL/6 mice were exposed to SF for 8 weeks. Their body weight, food consumption, and metabolic expenditure were monitored over time, and their plasma leptin levels measured after exposure to SF for 1 day as well as for 2 weeks. In addition, adipose tissue distribution was assessed at the end of the SF exposure using MRI techniques. Results Chronic SF-induced obesogenic behaviors and increased weight gain in mice by promoting increased caloric intake without changing caloric expenditure. Plasma leptin levels initially decreased and subsequently increased. Furthermore, increases in both visceral and subcutaneous adipose tissue volumes occurred. Conclusions These results suggest that SF, a frequent occurrence in many disorders and more specifically in sleep apnea, is a potent inducer of obesity via activation of obesogenic behaviors and possibly leptin resistance, in the absence of global changes in energy expenditure.

Original languageEnglish
Pages (from-to)758-762
Number of pages5
JournalObesity
Volume22
Issue number3
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Sleep Deprivation
Leptin
Young Adult
Sleep
Obesity
Sleep Apnea Syndromes
Tissue Distribution
Health Expenditures
Adipose Tissue
Body Weight
Intra-Abdominal Fat
Subcutaneous Fat
Appetite
Energy Intake
Inbred C57BL Mouse
Energy Metabolism
Weight Gain
Insulin Resistance
Fats
Carbohydrates

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Wang, Y., Carreras, A., Lee, S. H., Hakim, F., Zhang, S. X., Nair, D., ... Gozal, D. (2014). Chronic sleep fragmentation promotes obesity in young adult mice. Obesity, 22(3), 758-762. https://doi.org/10.1002/oby.20616

Chronic sleep fragmentation promotes obesity in young adult mice. / Wang, Yang; Carreras, Alba; Lee, Seung Hoon; Hakim, Fahed; Zhang, Shelley X.; Nair, Deepti; Ye, Honggang; Gozal, David.

In: Obesity, Vol. 22, No. 3, 01.01.2014, p. 758-762.

Research output: Contribution to journalArticle

Wang, Y, Carreras, A, Lee, SH, Hakim, F, Zhang, SX, Nair, D, Ye, H & Gozal, D 2014, 'Chronic sleep fragmentation promotes obesity in young adult mice', Obesity, vol. 22, no. 3, pp. 758-762. https://doi.org/10.1002/oby.20616
Wang Y, Carreras A, Lee SH, Hakim F, Zhang SX, Nair D et al. Chronic sleep fragmentation promotes obesity in young adult mice. Obesity. 2014 Jan 1;22(3):758-762. https://doi.org/10.1002/oby.20616
Wang, Yang ; Carreras, Alba ; Lee, Seung Hoon ; Hakim, Fahed ; Zhang, Shelley X. ; Nair, Deepti ; Ye, Honggang ; Gozal, David. / Chronic sleep fragmentation promotes obesity in young adult mice. In: Obesity. 2014 ; Vol. 22, No. 3. pp. 758-762.
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