CIIA is a novel regulator of detachment-induced cell death

Kwang Je Kim, Je Wook Yu, Hyun Sub Hwang, Eui Ju Choi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Detachment-induced cell death, or anoikis, is a type of apoptosis that occurs when epithelial cells lose their attachment to the extracellular matrix. Anoikis serves as a physiologic barrier to metastasis. Deviation from the tightly regulated mechanism of detachment-induced cell death might result in progression to metastatic cancer. Here, we investigated the function of CIIA in the regulation of anoikis. CIIA protein was upregulated in colon cancer tissue samples. Knockdown of CIIA in metastatic colorectal carcinoma SW620 and KM12SM cells promoted detachment-induced cell death through the regulation of caspase activation. Knockdown of CIIA also inhibited anchorage-independent growth in soft agar and colony formation after suspension stress. These observations suggest that CIIA is a novel negative regulator of anoikis.

Original languageEnglish
Pages (from-to)6352-6358
Number of pages7
JournalCancer Research
Volume70
Issue number15
DOIs
Publication statusPublished - 2010 Aug 1

Fingerprint

Anoikis
Cell Death
Caspases
Colonic Neoplasms
Agar
Extracellular Matrix
Colorectal Neoplasms
Suspensions
Epithelial Cells
Apoptosis
Neoplasm Metastasis
Growth
Neoplasms
Proteins

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

CIIA is a novel regulator of detachment-induced cell death. / Kim, Kwang Je; Yu, Je Wook; Hwang, Hyun Sub; Choi, Eui Ju.

In: Cancer Research, Vol. 70, No. 15, 01.08.2010, p. 6352-6358.

Research output: Contribution to journalArticle

Kim, Kwang Je ; Yu, Je Wook ; Hwang, Hyun Sub ; Choi, Eui Ju. / CIIA is a novel regulator of detachment-induced cell death. In: Cancer Research. 2010 ; Vol. 70, No. 15. pp. 6352-6358.
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