Circulating endothelial progenitor cells in gynaecological cancer

Yoon Byoung Kim, Ye Won Chung, Hyo Sook Bae, Jae Kwan Lee, Nak Woo Lee, Kyu Wan Lee, Jae Yun Song

    Research output: Contribution to journalArticlepeer-review

    8 Citations (Scopus)

    Abstract

    Objectives: To compare the frequency and absolute numbers of circulating endothelial progenitor cells (EPCs) in healthy control subjects and patients with gynaecological cancer, and to test the hypothesis that cancer treatment lowers EPC numbers. Methods: Patients with cervical or ovarian cancer and healthy control subjects provided peripheral blood samples for the isolation of mononuclear cells. EPCs were identified by quadruple immunofluorescence staining and flow cytometry as CD45-/CD34+/CD133+/vascular endothelial growth factor receptor 2 (VEGFR2)+ cells. Results: In total, 28 participants were enrolled. Circulating EPCs were present at higher frequencies (and in greater absolute numbers) in patients with cervical or ovarian cancer (n=14) than in controls (n=14). Concurrent chemoradiation therapy or surgery significantly reduced the frequency and number of EPCs in patients with gynaecological cancer, compared with pretreatment levels. Conclusions: EPC levels decline throughout cancer treatment; their measurement may therefore be a useful surrogate marker to monitor treatment response.

    Original languageEnglish
    Pages (from-to)293-299
    Number of pages7
    JournalJournal of International Medical Research
    Volume41
    Issue number2
    DOIs
    Publication statusPublished - 2013 Apr

    Keywords

    • Cervical cancer
    • Circulating endothelial progenitor cells
    • Ovarian cancer

    ASJC Scopus subject areas

    • Biochemistry
    • Cell Biology
    • Biochemistry, medical

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