Zirkulierender Leptinwert bei rheumatischer Arthritis und seine Korrelation mit der Erkrankungsaktivität: eine Metaanalyse

Translated title of the contribution: Circulating leptin level in rheumatoid arthritis and its correlation with disease activity: a meta-analysis

Young Ho Lee, S. C. Bae

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: This study aimed to evaluate the relationship between the circulating serum leptin level and rheumatoid arthritis (RA) and to establish a correlation between serum leptin levels and RA activity. Methods: We searched the PUBMED, EMBASE, and Cochrane databases. A meta-analysis was performed, comparing the serum/plasma leptin levels in patients with RA and healthy controls. Correlation coefficients between serum leptin level and either disease activity score 28 (DAS28) or C‑reactive protein (CRP) in RA patients were also examined. Results: Thirteen studies with a total of 648 RA patients and 426 controls were included in this meta-analysis. Circulating leptin level was significantly higher in the RA group than in the control group (SMD = 1.056, 95 % CI = 0.647–1.465, p = 4.2 × 10−7). In addition, stratification by ethnicity showed a significantly elevated leptin level in the RA group in Caucasian, Turkish, and Arab populations (SMD = 0.813, 95 % CI = 0.137–1.490, p = 0.018, SMD = 0.981, 95 % CI = 0.307–1.655, p = 0.004, and SMD = 1.469, 95 % CI = 0.443–2.495, p = 0.005 respectively). A meta-analysis of correlation coefficients showed a small but significantly positive correlation between the circulating leptin level and either DAS28 (correlation coefficient = 0.275, 95 % CI = 0.076–0.452, p = 0.007) or CRP (correlation coefficient = 0.274, 95 % CI = 0.068–0.458, p = 0.010). Conclusions: Our meta-analysis demonstrated that the circulating leptin level is significantly higher in patients with RA and that a small but significantly positive correlation exists between leptin levels and RA activity.

Original languageGerman
Pages (from-to)1021-1027
Number of pages7
JournalZeitschrift fur Rheumatologie
Volume75
Issue number10
DOIs
Publication statusPublished - 2016 Dec 1

Fingerprint

Leptin
Meta-Analysis
Rheumatoid Arthritis
Serum
Proteins
Databases
Control Groups

Keywords

  • Activity
  • Correlation
  • Leptin
  • Meta-analysis
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology

Cite this

Zirkulierender Leptinwert bei rheumatischer Arthritis und seine Korrelation mit der Erkrankungsaktivität : eine Metaanalyse. / Lee, Young Ho; Bae, S. C.

In: Zeitschrift fur Rheumatologie, Vol. 75, No. 10, 01.12.2016, p. 1021-1027.

Research output: Contribution to journalArticle

@article{bfe424533e3a4203bd110a794b571b4c,
title = "Zirkulierender Leptinwert bei rheumatischer Arthritis und seine Korrelation mit der Erkrankungsaktivit{\"a}t: eine Metaanalyse",
abstract = "Objective: This study aimed to evaluate the relationship between the circulating serum leptin level and rheumatoid arthritis (RA) and to establish a correlation between serum leptin levels and RA activity. Methods: We searched the PUBMED, EMBASE, and Cochrane databases. A meta-analysis was performed, comparing the serum/plasma leptin levels in patients with RA and healthy controls. Correlation coefficients between serum leptin level and either disease activity score 28 (DAS28) or C‑reactive protein (CRP) in RA patients were also examined. Results: Thirteen studies with a total of 648 RA patients and 426 controls were included in this meta-analysis. Circulating leptin level was significantly higher in the RA group than in the control group (SMD = 1.056, 95 {\%} CI = 0.647–1.465, p = 4.2 × 10−7). In addition, stratification by ethnicity showed a significantly elevated leptin level in the RA group in Caucasian, Turkish, and Arab populations (SMD = 0.813, 95 {\%} CI = 0.137–1.490, p = 0.018, SMD = 0.981, 95 {\%} CI = 0.307–1.655, p = 0.004, and SMD = 1.469, 95 {\%} CI = 0.443–2.495, p = 0.005 respectively). A meta-analysis of correlation coefficients showed a small but significantly positive correlation between the circulating leptin level and either DAS28 (correlation coefficient = 0.275, 95 {\%} CI = 0.076–0.452, p = 0.007) or CRP (correlation coefficient = 0.274, 95 {\%} CI = 0.068–0.458, p = 0.010). Conclusions: Our meta-analysis demonstrated that the circulating leptin level is significantly higher in patients with RA and that a small but significantly positive correlation exists between leptin levels and RA activity.",
keywords = "Activity, Correlation, Leptin, Meta-analysis, Rheumatoid arthritis",
author = "Lee, {Young Ho} and Bae, {S. C.}",
year = "2016",
month = "12",
day = "1",
doi = "10.1007/s00393-016-0050-1",
language = "German",
volume = "75",
pages = "1021--1027",
journal = "Zeitschrift fur Rheumatologie",
issn = "0340-1855",
publisher = "D. Steinkopff-Verlag",
number = "10",

}

TY - JOUR

T1 - Zirkulierender Leptinwert bei rheumatischer Arthritis und seine Korrelation mit der Erkrankungsaktivität

T2 - eine Metaanalyse

AU - Lee, Young Ho

AU - Bae, S. C.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Objective: This study aimed to evaluate the relationship between the circulating serum leptin level and rheumatoid arthritis (RA) and to establish a correlation between serum leptin levels and RA activity. Methods: We searched the PUBMED, EMBASE, and Cochrane databases. A meta-analysis was performed, comparing the serum/plasma leptin levels in patients with RA and healthy controls. Correlation coefficients between serum leptin level and either disease activity score 28 (DAS28) or C‑reactive protein (CRP) in RA patients were also examined. Results: Thirteen studies with a total of 648 RA patients and 426 controls were included in this meta-analysis. Circulating leptin level was significantly higher in the RA group than in the control group (SMD = 1.056, 95 % CI = 0.647–1.465, p = 4.2 × 10−7). In addition, stratification by ethnicity showed a significantly elevated leptin level in the RA group in Caucasian, Turkish, and Arab populations (SMD = 0.813, 95 % CI = 0.137–1.490, p = 0.018, SMD = 0.981, 95 % CI = 0.307–1.655, p = 0.004, and SMD = 1.469, 95 % CI = 0.443–2.495, p = 0.005 respectively). A meta-analysis of correlation coefficients showed a small but significantly positive correlation between the circulating leptin level and either DAS28 (correlation coefficient = 0.275, 95 % CI = 0.076–0.452, p = 0.007) or CRP (correlation coefficient = 0.274, 95 % CI = 0.068–0.458, p = 0.010). Conclusions: Our meta-analysis demonstrated that the circulating leptin level is significantly higher in patients with RA and that a small but significantly positive correlation exists between leptin levels and RA activity.

AB - Objective: This study aimed to evaluate the relationship between the circulating serum leptin level and rheumatoid arthritis (RA) and to establish a correlation between serum leptin levels and RA activity. Methods: We searched the PUBMED, EMBASE, and Cochrane databases. A meta-analysis was performed, comparing the serum/plasma leptin levels in patients with RA and healthy controls. Correlation coefficients between serum leptin level and either disease activity score 28 (DAS28) or C‑reactive protein (CRP) in RA patients were also examined. Results: Thirteen studies with a total of 648 RA patients and 426 controls were included in this meta-analysis. Circulating leptin level was significantly higher in the RA group than in the control group (SMD = 1.056, 95 % CI = 0.647–1.465, p = 4.2 × 10−7). In addition, stratification by ethnicity showed a significantly elevated leptin level in the RA group in Caucasian, Turkish, and Arab populations (SMD = 0.813, 95 % CI = 0.137–1.490, p = 0.018, SMD = 0.981, 95 % CI = 0.307–1.655, p = 0.004, and SMD = 1.469, 95 % CI = 0.443–2.495, p = 0.005 respectively). A meta-analysis of correlation coefficients showed a small but significantly positive correlation between the circulating leptin level and either DAS28 (correlation coefficient = 0.275, 95 % CI = 0.076–0.452, p = 0.007) or CRP (correlation coefficient = 0.274, 95 % CI = 0.068–0.458, p = 0.010). Conclusions: Our meta-analysis demonstrated that the circulating leptin level is significantly higher in patients with RA and that a small but significantly positive correlation exists between leptin levels and RA activity.

KW - Activity

KW - Correlation

KW - Leptin

KW - Meta-analysis

KW - Rheumatoid arthritis

UR - http://www.scopus.com/inward/record.url?scp=84955576187&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955576187&partnerID=8YFLogxK

U2 - 10.1007/s00393-016-0050-1

DO - 10.1007/s00393-016-0050-1

M3 - Article

C2 - 26820722

AN - SCOPUS:84955576187

VL - 75

SP - 1021

EP - 1027

JO - Zeitschrift fur Rheumatologie

JF - Zeitschrift fur Rheumatologie

SN - 0340-1855

IS - 10

ER -