Zirkulierender Leptinwert bei rheumatischer Arthritis und seine Korrelation mit der Erkrankungsaktivität: eine Metaanalyse

Translated title of the contribution: Circulating leptin level in rheumatoid arthritis and its correlation with disease activity: a meta-analysis

Y. H. Lee, S. C. Bae

    Research output: Contribution to journalArticlepeer-review

    23 Citations (Scopus)

    Abstract

    Objective: This study aimed to evaluate the relationship between the circulating serum leptin level and rheumatoid arthritis (RA) and to establish a correlation between serum leptin levels and RA activity. Methods: We searched the PUBMED, EMBASE, and Cochrane databases. A meta-analysis was performed, comparing the serum/plasma leptin levels in patients with RA and healthy controls. Correlation coefficients between serum leptin level and either disease activity score 28 (DAS28) or C‑reactive protein (CRP) in RA patients were also examined. Results: Thirteen studies with a total of 648 RA patients and 426 controls were included in this meta-analysis. Circulating leptin level was significantly higher in the RA group than in the control group (SMD = 1.056, 95 % CI = 0.647–1.465, p = 4.2 × 10−7). In addition, stratification by ethnicity showed a significantly elevated leptin level in the RA group in Caucasian, Turkish, and Arab populations (SMD = 0.813, 95 % CI = 0.137–1.490, p = 0.018, SMD = 0.981, 95 % CI = 0.307–1.655, p = 0.004, and SMD = 1.469, 95 % CI = 0.443–2.495, p = 0.005 respectively). A meta-analysis of correlation coefficients showed a small but significantly positive correlation between the circulating leptin level and either DAS28 (correlation coefficient = 0.275, 95 % CI = 0.076–0.452, p = 0.007) or CRP (correlation coefficient = 0.274, 95 % CI = 0.068–0.458, p = 0.010). Conclusions: Our meta-analysis demonstrated that the circulating leptin level is significantly higher in patients with RA and that a small but significantly positive correlation exists between leptin levels and RA activity.

    Translated title of the contributionCirculating leptin level in rheumatoid arthritis and its correlation with disease activity: a meta-analysis
    Original languageGerman
    Pages (from-to)1021-1027
    Number of pages7
    JournalZeitschrift fur Rheumatologie
    Volume75
    Issue number10
    DOIs
    Publication statusPublished - 2016 Dec 1

    Keywords

    • Activity
    • Correlation
    • Leptin
    • Meta-analysis
    • Rheumatoid arthritis

    ASJC Scopus subject areas

    • Rheumatology

    Fingerprint

    Dive into the research topics of 'Circulating leptin level in rheumatoid arthritis and its correlation with disease activity: a meta-analysis'. Together they form a unique fingerprint.

    Cite this