Cisatracurium pretreatment with tourniquet reduces propofol injection pain: A double-blind randomized controlled trial

Yun-Hee Kim, Jin Namgung, Choon Hak Lim

Research output: Contribution to journalArticle

4 Citations (Scopus)


Objectives: To investigate the efficacy of pretreatment with cisatracurium for prevention of pain associated with propofol injection, and compare its efficacy with that of lidocaine. Methods: Patients undergoing general anaesthesia were randomized to receive normal saline (control group), lidocaine (0.5 mg/kg), 0.03 mg/kg cisatracurium or 0.15 mg/kg cisatracurium. All drugs were administered into the largest dorsal vein of the hand with venous occlusion for 30 s, followed by propofol (0.5 mg/kg). Pain was evaluated using a four-point scale. Results: The incidence and severity of pain was significantly lower in the lidocaine and 0.15 mg/kg cisatracurium groups than the control and 0.03 mg/kg cisatracurium groups (n=50/group). There was no significant difference between the lidocaine and 0.15 mg/kg cisatracurium groups in the incidence and severity of pain. Conclusions: 0.15 mg/kg cisatracurium effectively decreases the incidence and severity of pain induced by propofol injection without any significant complications.

Original languageEnglish
Pages (from-to)360-367
Number of pages8
JournalJournal of International Medical Research
Issue number2
Publication statusPublished - 2014 Jan 1



  • Cisatracurium
  • general anaesthesia
  • propofol injection pain

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

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