Cisatracurium pretreatment with tourniquet reduces propofol injection pain: A double-blind randomized controlled trial

Yun Hee Kim, Jin Namgung, Choon Hak Lim

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)

    Abstract

    Objectives: To investigate the efficacy of pretreatment with cisatracurium for prevention of pain associated with propofol injection, and compare its efficacy with that of lidocaine. Methods: Patients undergoing general anaesthesia were randomized to receive normal saline (control group), lidocaine (0.5 mg/kg), 0.03 mg/kg cisatracurium or 0.15 mg/kg cisatracurium. All drugs were administered into the largest dorsal vein of the hand with venous occlusion for 30 s, followed by propofol (0.5 mg/kg). Pain was evaluated using a four-point scale. Results: The incidence and severity of pain was significantly lower in the lidocaine and 0.15 mg/kg cisatracurium groups than the control and 0.03 mg/kg cisatracurium groups (n=50/group). There was no significant difference between the lidocaine and 0.15 mg/kg cisatracurium groups in the incidence and severity of pain. Conclusions: 0.15 mg/kg cisatracurium effectively decreases the incidence and severity of pain induced by propofol injection without any significant complications.

    Original languageEnglish
    Pages (from-to)360-367
    Number of pages8
    JournalJournal of International Medical Research
    Volume42
    Issue number2
    DOIs
    Publication statusPublished - 2014 Apr

    Keywords

    • Cisatracurium
    • general anaesthesia
    • propofol injection pain

    ASJC Scopus subject areas

    • Biochemistry
    • Biochemistry, medical
    • Cell Biology

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