Cleavage-induced fluorescence change via hydrophilicity control: A new strategy for biological application

Chang Keun Lim, Jin Seong Lee, Tai Hwan Ha, Ick Chan Kwon, Cheol Hee Ahn, Soo Young Park

Research output: Contribution to journalArticle

3 Citations (Scopus)


In this work, we report a novel stimuli-sensitive probe working on the principle of the cleavage-induced fluorescent change via hydrophilicity control. In our Si-Py-Ac-PEG probe, cleavage of hydrophilic PEG moiety in acidic environment induces hydrophobic interaction of pyrenes to increase their excimer emission. Our fluorescent probe (Si-Py-Ac-PEG) was successfully applied to the spotting microarray and nanoparticle suspension to demonstrate the potential of biological applications, i.e. protein chip and bioimaging.

Original languageEnglish
Pages (from-to)149-154
Number of pages6
JournalJournal of Photochemistry and Photobiology A: Chemistry
Issue number2-3
Publication statusPublished - 2007 May 20
Externally publishedYes



  • Biomedical imaging
  • Cleavage
  • Excimer emission
  • Hydrophilicity control
  • Microarray

ASJC Scopus subject areas

  • Bioengineering
  • Physical and Theoretical Chemistry

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