Cleavage-induced fluorescence change via hydrophilicity control: A new strategy for biological application

Chang Keun Lim; Jin Seong Lee; Tai Hwan Ha; Ick Chan Kwon; Cheol Hee Ahn; Soo Young Park

doi:10.1016/j.jphotochem.2006.12.002

Cleavage-induced fluorescence change via hydrophilicity control: A new strategy for biological application

Chang Keun Lim, Jin Seong Lee, Tai Hwan Ha, Ick Chan Kwon, Cheol Hee Ahn, Soo Young Park

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

In this work, we report a novel stimuli-sensitive probe working on the principle of the cleavage-induced fluorescent change via hydrophilicity control. In our Si-Py-Ac-PEG probe, cleavage of hydrophilic PEG moiety in acidic environment induces hydrophobic interaction of pyrenes to increase their excimer emission. Our fluorescent probe (Si-Py-Ac-PEG) was successfully applied to the spotting microarray and nanoparticle suspension to demonstrate the potential of biological applications, i.e. protein chip and bioimaging.

Original language	English
Pages (from-to)	149-154
Number of pages	6
Journal	Journal of Photochemistry and Photobiology A: Chemistry
Volume	188
Issue number	2-3
DOIs	https://doi.org/10.1016/j.jphotochem.2006.12.002
Publication status	Published - 2007 May 20
Externally published	Yes

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Keywords

Biomedical imaging
Cleavage
Excimer emission
Hydrophilicity control
Microarray

ASJC Scopus subject areas

Bioengineering
Physical and Theoretical Chemistry

Cite this

Lim, C. K., Lee, J. S., Ha, T. H., Kwon, I. C., Ahn, C. H., & Park, S. Y. (2007). Cleavage-induced fluorescence change via hydrophilicity control: A new strategy for biological application. Journal of Photochemistry and Photobiology A: Chemistry, 188(2-3), 149-154. https://doi.org/10.1016/j.jphotochem.2006.12.002

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AU - Ha, Tai Hwan

AU - Kwon, Ick Chan

AU - Ahn, Cheol Hee

AU - Park, Soo Young

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KW - Excimer emission

KW - Hydrophilicity control

KW - Microarray

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10.1016/j.jphotochem.2006.12.002