Abstract
In this work, we report a novel stimuli-sensitive probe working on the principle of the cleavage-induced fluorescent change via hydrophilicity control. In our Si-Py-Ac-PEG probe, cleavage of hydrophilic PEG moiety in acidic environment induces hydrophobic interaction of pyrenes to increase their excimer emission. Our fluorescent probe (Si-Py-Ac-PEG) was successfully applied to the spotting microarray and nanoparticle suspension to demonstrate the potential of biological applications, i.e. protein chip and bioimaging.
| Original language | English |
|---|---|
| Pages (from-to) | 149-154 |
| Number of pages | 6 |
| Journal | Journal of Photochemistry and Photobiology A: Chemistry |
| Volume | 188 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - 2007 May 20 |
| Externally published | Yes |
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Keywords
- Biomedical imaging
- Cleavage
- Excimer emission
- Hydrophilicity control
- Microarray
ASJC Scopus subject areas
- Bioengineering
- Physical and Theoretical Chemistry
Cite this
Cleavage-induced fluorescence change via hydrophilicity control : A new strategy for biological application. / Lim, Chang Keun; Lee, Jin Seong; Ha, Tai Hwan; Kwon, Ick Chan; Ahn, Cheol Hee; Park, Soo Young.
In: Journal of Photochemistry and Photobiology A: Chemistry, Vol. 188, No. 2-3, 20.05.2007, p. 149-154.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cleavage-induced fluorescence change via hydrophilicity control
T2 - A new strategy for biological application
AU - Lim, Chang Keun
AU - Lee, Jin Seong
AU - Ha, Tai Hwan
AU - Kwon, Ick Chan
AU - Ahn, Cheol Hee
AU - Park, Soo Young
PY - 2007/5/20
Y1 - 2007/5/20
N2 - In this work, we report a novel stimuli-sensitive probe working on the principle of the cleavage-induced fluorescent change via hydrophilicity control. In our Si-Py-Ac-PEG probe, cleavage of hydrophilic PEG moiety in acidic environment induces hydrophobic interaction of pyrenes to increase their excimer emission. Our fluorescent probe (Si-Py-Ac-PEG) was successfully applied to the spotting microarray and nanoparticle suspension to demonstrate the potential of biological applications, i.e. protein chip and bioimaging.
AB - In this work, we report a novel stimuli-sensitive probe working on the principle of the cleavage-induced fluorescent change via hydrophilicity control. In our Si-Py-Ac-PEG probe, cleavage of hydrophilic PEG moiety in acidic environment induces hydrophobic interaction of pyrenes to increase their excimer emission. Our fluorescent probe (Si-Py-Ac-PEG) was successfully applied to the spotting microarray and nanoparticle suspension to demonstrate the potential of biological applications, i.e. protein chip and bioimaging.
KW - Biomedical imaging
KW - Cleavage
KW - Excimer emission
KW - Hydrophilicity control
KW - Microarray
UR - http://www.scopus.com/inward/record.url?scp=34247126964&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34247126964&partnerID=8YFLogxK
U2 - 10.1016/j.jphotochem.2006.12.002
DO - 10.1016/j.jphotochem.2006.12.002
M3 - Article
AN - SCOPUS:34247126964
VL - 188
SP - 149
EP - 154
JO - Journal of Photochemistry and Photobiology A: Chemistry
JF - Journal of Photochemistry and Photobiology A: Chemistry
SN - 1010-6030
IS - 2-3
ER -