Clerodane diterpenoids from Casearia kurzii and their cytotoxic activities

Yuan Shuo, Chenyue Zhang, Xueyuan Yang, Feng Liu, Qi Zhang, Annan Li, Jun Ma, Dongho Lee, Yasushi Ohizumi, Yuanqiang Guo

Research output: Contribution to journalArticle

Abstract

Abstract: A search for bioactive natural products as anticancer lead compounds resulted in the isolation of one previously undescribed and three known clerodane diterpenoids (1–4) from Casearia kurzii. The structures of these compounds were established by analysis of their NMR, MS, and electronic circular dichroism data. The cytotoxic activities of four compounds against three human cancer cell lines were evaluated. Compound 2 was found to be the most active with an IC50 value of 4.1 μM against HeLa cells, and was selected to investigate the possible cytotoxic mechanism. Graphic abstract: [Figure not available: see fulltext.]

Original languageEnglish
JournalJournal of Natural Medicines
DOIs
Publication statusPublished - 2019 Jan 1

Keywords

  • Apoptosis
  • Casearia kurzii
  • Cell cycle
  • Clerodane diterpenoids
  • Cytotoxic activities

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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  • Cite this

    Shuo, Y., Zhang, C., Yang, X., Liu, F., Zhang, Q., Li, A., Ma, J., Lee, D., Ohizumi, Y., & Guo, Y. (2019). Clerodane diterpenoids from Casearia kurzii and their cytotoxic activities. Journal of Natural Medicines. https://doi.org/10.1007/s11418-019-01324-5