Clinical and echocardiographic findings of newly diagnosed acute decompensated heart failure in elderly patients

Jeonggeun Moon, Seok Min Kang, In Jeong Cho, Jaewon Oh, Jaemin Shim, Sang Hak Lee, Yangsoo Jang, Namsik Chung

Research output: Contribution to journalArticle

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Abstract

Purpose: Elderly patients (pts) (EPs; ≥ 65 years old) with newly diagnosed-acute decompensated heart failure (ND-ADHF) have not yet been studied. The aim of the present study was to investigate clinical characteristics, including echocardiographic findings and prognosis, for EPs with ND-ADHF and to compare those with non-elderly pts (NEPs). Materials and Methods: We retrospectively investigated 256 pts (144 males, 63.0 ± 14.8 years old) who were admitted to our hospital between January 2005 and March 2009 with ND-ADHF. Clinical characteristics and echocardiographic parameters were analyzed in EPs (n = 135, 58 males) and NEPs (n = 121, 86 males). Results: In intergroup comparison, female gender, diabetes mellitus, previous stroke and hypertension were more common in EPs. Body mass index (22.3 ± 4.5 vs. 24.0 ± 4.4 kg/m2), estimated glomerular filtration rate (54.8 ± 24.3 vs. 69.2 ± 30.7 mL/min/m2), C-reactive protein (28.5 ± 46.9 vs. 7.6 ± 11.6 mg/dL), hemoglobin (12.3 ± 2.1 vs. 13.6 ± 2.3 g/dL) and N-terminal pro-brain natriuretic peptide level (10,538.2 ± 10,942.3 vs. 6,771.0 ± 8,964.7 pg/mL) were significantly different (p < 0.05 for all). Early mitral inflow velocity to early diastolic mitral annular velocity (E/E') was significantly higher in EPs than in NEPs (21.2 ± 9.4 vs. 18.0 ± 8.9, p < 0.05). During follow-up (44.7 ± 14.5 months), there were no significant differences in in-hospital mortality, re-hospitalization and cardiovascular mortality between EPs and NEPs (p = NS for all). Conclusion: EPs with ND-ADHF have different clinical characteristics and higher LV filling pressure when compared with NEPs. However, the clinical outcomes for NEPs with ND-ADHF are not necessarily more favorable than those for EPs.

Original languageEnglish
Pages (from-to)33-38
Number of pages6
JournalYonsei Medical Journal
Volume52
Issue number1
DOIs
Publication statusPublished - 2011 Jan 1
Externally publishedYes

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Heart Failure
Brain Natriuretic Peptide
Hospital Mortality
Glomerular Filtration Rate
C-Reactive Protein
Diabetes Mellitus
Hemoglobins
Hospitalization
Body Mass Index
Stroke
Hypertension
Pressure
Mortality

Keywords

  • Acute heart failure
  • Echocardiography
  • Elderly patients

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Clinical and echocardiographic findings of newly diagnosed acute decompensated heart failure in elderly patients. / Moon, Jeonggeun; Kang, Seok Min; Cho, In Jeong; Oh, Jaewon; Shim, Jaemin; Lee, Sang Hak; Jang, Yangsoo; Chung, Namsik.

In: Yonsei Medical Journal, Vol. 52, No. 1, 01.01.2011, p. 33-38.

Research output: Contribution to journalArticle

Moon, Jeonggeun ; Kang, Seok Min ; Cho, In Jeong ; Oh, Jaewon ; Shim, Jaemin ; Lee, Sang Hak ; Jang, Yangsoo ; Chung, Namsik. / Clinical and echocardiographic findings of newly diagnosed acute decompensated heart failure in elderly patients. In: Yonsei Medical Journal. 2011 ; Vol. 52, No. 1. pp. 33-38.
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AU - Kang, Seok Min

AU - Cho, In Jeong

AU - Oh, Jaewon

AU - Shim, Jaemin

AU - Lee, Sang Hak

AU - Jang, Yangsoo

AU - Chung, Namsik

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N2 - Purpose: Elderly patients (pts) (EPs; ≥ 65 years old) with newly diagnosed-acute decompensated heart failure (ND-ADHF) have not yet been studied. The aim of the present study was to investigate clinical characteristics, including echocardiographic findings and prognosis, for EPs with ND-ADHF and to compare those with non-elderly pts (NEPs). Materials and Methods: We retrospectively investigated 256 pts (144 males, 63.0 ± 14.8 years old) who were admitted to our hospital between January 2005 and March 2009 with ND-ADHF. Clinical characteristics and echocardiographic parameters were analyzed in EPs (n = 135, 58 males) and NEPs (n = 121, 86 males). Results: In intergroup comparison, female gender, diabetes mellitus, previous stroke and hypertension were more common in EPs. Body mass index (22.3 ± 4.5 vs. 24.0 ± 4.4 kg/m2), estimated glomerular filtration rate (54.8 ± 24.3 vs. 69.2 ± 30.7 mL/min/m2), C-reactive protein (28.5 ± 46.9 vs. 7.6 ± 11.6 mg/dL), hemoglobin (12.3 ± 2.1 vs. 13.6 ± 2.3 g/dL) and N-terminal pro-brain natriuretic peptide level (10,538.2 ± 10,942.3 vs. 6,771.0 ± 8,964.7 pg/mL) were significantly different (p < 0.05 for all). Early mitral inflow velocity to early diastolic mitral annular velocity (E/E') was significantly higher in EPs than in NEPs (21.2 ± 9.4 vs. 18.0 ± 8.9, p < 0.05). During follow-up (44.7 ± 14.5 months), there were no significant differences in in-hospital mortality, re-hospitalization and cardiovascular mortality between EPs and NEPs (p = NS for all). Conclusion: EPs with ND-ADHF have different clinical characteristics and higher LV filling pressure when compared with NEPs. However, the clinical outcomes for NEPs with ND-ADHF are not necessarily more favorable than those for EPs.

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