Clinical and economic analysis of the 2009 H1N1 influenza pandemic among pregnant Korean women

Won Suk Choi, Min Joo Choi, Ji Yoon Noh, Joon Young Song, Woo Joo Kim, Dae Won Park, Jacob Lee, Yu Bin Seo, Ji Hyeon Baek, Sooran Choi, Hee Jin Cheong

Research output: Contribution to journalArticle

Abstract

BACKGROUND/AIMS: Unlike Western countries, the 2009 pandemic influenza infection among pregnant women was reported as mild in a previous interim study in South Korea. However, several mortalities were reported thereafter, suggesting that nationwide data were lacking. METHODS: This case-control study covers the entire 2009 pandemic inf luenza period, from May 2009 to February 2010. The clinical and economic data of pregnant (case) and age-matched non-pregnant (control) women with influenza A (H1N1) pdm09 virus (H1N1pdm09) infection were retrospectively collected from nine hospitals in South Korea. RESULTS: A total of 130 pregnant women with H1N1pdm09 infection were identified. The mean age of the pregnant women was 31.1 years (range, 19 to 41) and mean gestational age was 18.4 weeks (range, 3 to 40). Both case and control groups were similar in terms of age (p = 0.43) and comorbidities (p = 0.18). The overall rate of complications was comparable between the two groups (p = 0.648). However, mortality was reported only among the cases, so mean economic per capita burden is estimated to be higher for pregnant women compared to the control (4,821,992 Korean won [KRW] vs. 351,233 KRW, p = 0.31). Obstetric complications were observed in 12 cases, including preterm labor (n = 7), low birth-weight (n = 3), miscarriage (n = 1), stillbirth (n = 1), and cleft lip (n = 1). CONCLUSION: Although statistically insignificant, the detrimental impact of influenza A H1N1pdm09 on pregnancy can be serious in some complicated cases in South Korea. Thus, the strong recommendation of influenza vaccination should be maintained for pregnant women as a high priority.

Original languageEnglish
Pages (from-to)1136-1144
Number of pages9
JournalThe Korean journal of internal medicine
Volume34
Issue number5
DOIs
Publication statusPublished - 2019 Sep 1

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Pandemics
Human Influenza
Pregnant Women
H1N1 Subtype Influenza A Virus
Republic of Korea
Economics
Virus Diseases
Stillbirth
Mortality
Premature Obstetric Labor
Cleft Lip
Low Birth Weight Infant
Spontaneous Abortion
Gestational Age
Obstetrics
Case-Control Studies
Comorbidity
Vaccination
Pregnancy
Control Groups

Keywords

  • H1N1
  • Influenza, human
  • Pandemics
  • Pregnancy

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Clinical and economic analysis of the 2009 H1N1 influenza pandemic among pregnant Korean women. / Choi, Won Suk; Choi, Min Joo; Noh, Ji Yoon; Song, Joon Young; Kim, Woo Joo; Park, Dae Won; Lee, Jacob; Seo, Yu Bin; Baek, Ji Hyeon; Choi, Sooran; Cheong, Hee Jin.

In: The Korean journal of internal medicine, Vol. 34, No. 5, 01.09.2019, p. 1136-1144.

Research output: Contribution to journalArticle

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AU - Choi, Min Joo

AU - Noh, Ji Yoon

AU - Song, Joon Young

AU - Kim, Woo Joo

AU - Park, Dae Won

AU - Lee, Jacob

AU - Seo, Yu Bin

AU - Baek, Ji Hyeon

AU - Choi, Sooran

AU - Cheong, Hee Jin

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AB - BACKGROUND/AIMS: Unlike Western countries, the 2009 pandemic influenza infection among pregnant women was reported as mild in a previous interim study in South Korea. However, several mortalities were reported thereafter, suggesting that nationwide data were lacking. METHODS: This case-control study covers the entire 2009 pandemic inf luenza period, from May 2009 to February 2010. The clinical and economic data of pregnant (case) and age-matched non-pregnant (control) women with influenza A (H1N1) pdm09 virus (H1N1pdm09) infection were retrospectively collected from nine hospitals in South Korea. RESULTS: A total of 130 pregnant women with H1N1pdm09 infection were identified. The mean age of the pregnant women was 31.1 years (range, 19 to 41) and mean gestational age was 18.4 weeks (range, 3 to 40). Both case and control groups were similar in terms of age (p = 0.43) and comorbidities (p = 0.18). The overall rate of complications was comparable between the two groups (p = 0.648). However, mortality was reported only among the cases, so mean economic per capita burden is estimated to be higher for pregnant women compared to the control (4,821,992 Korean won [KRW] vs. 351,233 KRW, p = 0.31). Obstetric complications were observed in 12 cases, including preterm labor (n = 7), low birth-weight (n = 3), miscarriage (n = 1), stillbirth (n = 1), and cleft lip (n = 1). CONCLUSION: Although statistically insignificant, the detrimental impact of influenza A H1N1pdm09 on pregnancy can be serious in some complicated cases in South Korea. Thus, the strong recommendation of influenza vaccination should be maintained for pregnant women as a high priority.

KW - H1N1

KW - Influenza, human

KW - Pandemics

KW - Pregnancy

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