Abstract
Background The prevalence and social burden of type 2 diabetes mellitus (T2DM) is increasing. Medication adherence is necessary for positive outcomes in patients with T2DM. Objective This study evaluated the association between medication adherence and clinical/economic outcomes in patients with T2DM in the Republic of Korea over a 3-year period. Methods This study used data from the Korean National Diabetes Program at 5 hospitals. Medication possession ratios of ≥90% and <90% were used to define adherent and nonadherent groups, respectively. The degree of glycemic control, changes in blood pressure and lipid profiles, and health care costs were compared. Results Of the 608 patients, 472 were medication adherent and 136 were nonadherent. The adherent patients displayed improved fasting blood glucose and hemoglobin A1c during the study. Diastolic blood pressure and total cholesterol were lower at 36 months, and lower low-density lipoprotein cholesterol was noted at baseline and 24 months. The total health care costs were $1861, $2060, and $1924, respectively, versus $1617, $1751, and $1602 during the 3-year study period for the adherent group versus the nonadherent group, respectively (P = 0.316, 0.627, and 0.172, respectively), whereas the outpatient drug costs were $1143, $1176, and $1162 in the adherent group versus $925, $778, and $914 in the nonadherent group (P = 0.002, P < 0.001, and P = 0.001). Conclusions The adherent patients displayed better glycemic control and lipid profiles. Medication-related expenses were higher in the adherent group, but overall health care costs, including hospitalization costs, were similar between the 2 groups.
| Original language | English |
|---|---|
| Pages (from-to) | 245-254 |
| Number of pages | 10 |
| Journal | Clinical Therapeutics |
| Volume | 36 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2014 Feb 1 |
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Keywords
- adherence to medication
- clinical and economic outcomes
- type 2 diabetes mellitus
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
Cite this
Clinical and economic outcomes in medication-adherent and -nonadherent patients with type 2 diabetes mellitus in the republic of Korea. / An, So Yeon; Kim, Hae Jin; Chun, Ki Hong; Kim, Tae Ho; Jeon, Ja Young; Kim, Dae Jung; Han, Seung Jin; Kim, Young Seol; Woo, Jeong Taek; Ahn, Kyu Jeung; Park, Yongsoo; Nam, Moonsuk; Baik, Sei-Hyun; Lee, Kwan Woo.
In: Clinical Therapeutics, Vol. 36, No. 2, 01.02.2014, p. 245-254.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical and economic outcomes in medication-adherent and -nonadherent patients with type 2 diabetes mellitus in the republic of Korea
AU - An, So Yeon
AU - Kim, Hae Jin
AU - Chun, Ki Hong
AU - Kim, Tae Ho
AU - Jeon, Ja Young
AU - Kim, Dae Jung
AU - Han, Seung Jin
AU - Kim, Young Seol
AU - Woo, Jeong Taek
AU - Ahn, Kyu Jeung
AU - Park, Yongsoo
AU - Nam, Moonsuk
AU - Baik, Sei-Hyun
AU - Lee, Kwan Woo
PY - 2014/2/1
Y1 - 2014/2/1
N2 - Background The prevalence and social burden of type 2 diabetes mellitus (T2DM) is increasing. Medication adherence is necessary for positive outcomes in patients with T2DM. Objective This study evaluated the association between medication adherence and clinical/economic outcomes in patients with T2DM in the Republic of Korea over a 3-year period. Methods This study used data from the Korean National Diabetes Program at 5 hospitals. Medication possession ratios of ≥90% and <90% were used to define adherent and nonadherent groups, respectively. The degree of glycemic control, changes in blood pressure and lipid profiles, and health care costs were compared. Results Of the 608 patients, 472 were medication adherent and 136 were nonadherent. The adherent patients displayed improved fasting blood glucose and hemoglobin A1c during the study. Diastolic blood pressure and total cholesterol were lower at 36 months, and lower low-density lipoprotein cholesterol was noted at baseline and 24 months. The total health care costs were $1861, $2060, and $1924, respectively, versus $1617, $1751, and $1602 during the 3-year study period for the adherent group versus the nonadherent group, respectively (P = 0.316, 0.627, and 0.172, respectively), whereas the outpatient drug costs were $1143, $1176, and $1162 in the adherent group versus $925, $778, and $914 in the nonadherent group (P = 0.002, P < 0.001, and P = 0.001). Conclusions The adherent patients displayed better glycemic control and lipid profiles. Medication-related expenses were higher in the adherent group, but overall health care costs, including hospitalization costs, were similar between the 2 groups.
AB - Background The prevalence and social burden of type 2 diabetes mellitus (T2DM) is increasing. Medication adherence is necessary for positive outcomes in patients with T2DM. Objective This study evaluated the association between medication adherence and clinical/economic outcomes in patients with T2DM in the Republic of Korea over a 3-year period. Methods This study used data from the Korean National Diabetes Program at 5 hospitals. Medication possession ratios of ≥90% and <90% were used to define adherent and nonadherent groups, respectively. The degree of glycemic control, changes in blood pressure and lipid profiles, and health care costs were compared. Results Of the 608 patients, 472 were medication adherent and 136 were nonadherent. The adherent patients displayed improved fasting blood glucose and hemoglobin A1c during the study. Diastolic blood pressure and total cholesterol were lower at 36 months, and lower low-density lipoprotein cholesterol was noted at baseline and 24 months. The total health care costs were $1861, $2060, and $1924, respectively, versus $1617, $1751, and $1602 during the 3-year study period for the adherent group versus the nonadherent group, respectively (P = 0.316, 0.627, and 0.172, respectively), whereas the outpatient drug costs were $1143, $1176, and $1162 in the adherent group versus $925, $778, and $914 in the nonadherent group (P = 0.002, P < 0.001, and P = 0.001). Conclusions The adherent patients displayed better glycemic control and lipid profiles. Medication-related expenses were higher in the adherent group, but overall health care costs, including hospitalization costs, were similar between the 2 groups.
KW - adherence to medication
KW - clinical and economic outcomes
KW - type 2 diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=84894025856&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84894025856&partnerID=8YFLogxK
U2 - 10.1016/j.clinthera.2013.12.012
DO - 10.1016/j.clinthera.2013.12.012
M3 - Article
VL - 36
SP - 245
EP - 254
JO - Clinical Therapeutics
JF - Clinical Therapeutics
SN - 0149-2918
IS - 2
ER -