Clinical and immunologic findings of methylene diphenyl diisocyanate-induced occupational asthma in a car upholstery factory

G. Y. Hur, D. H. Koh, G. S. Choi, H. J. Park, S. J. Choi, Y. M. Ye, K. S. Kim, H. S. Park

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background: Although methylene diphenyl diisocyanate (MDI) is widely used in many industries, there have been few immunological studies of MDI-induced occupational asthma. Objectives: We investigated the effects of MDI exposure on the clinical and immunologic condition of workers in a single car upholstery factory. Methods: Fifty-eight MDI-exposed workers were studied. Work-related lower-respiratory symptoms (WRRS) were identified using a questionnaire. Serum-specific IgE and IgG antibodies to MDI-human serum albumin conjugate were detected by ELISA. Atopy was evaluated using a skin prick test. MDI-induced occupational asthma was confirmed in the symptomatic workers with a positive result on an MDI-specific inhalation test. Results: Thirteen (22.4%) of the subjects complained of WRRS. MDI-induced occupational asthma was confirmed in five (8.6%) of the workers, and occupational eosinophilic bronchitis was confirmed in two (3.5%). The prevalence of specific IgG antibodies (20.7%) was higher than that of specific IgE antibodies (8.6%). The prevalence of MDI-induced occupational asthma/eosinophilic bronchitis was strongly associated with the presence of both WRRS and serum-specific IgG antibodies to an MDI-human serum albumin conjugate (P<0.01, <0.05, respectively). Conclusion: These findings suggest that MDI could be a causative agent of occupational asthma among MDI-exposed workers. The prevalence of MDI-induced occupational asthma was 8.6%, and MDI-induced eosinophilic bronchitis was confirmed in two workers. The presence of work-related lower-respiratory symptoms and serum-specific IgG antibodies to an MDI-human serum albumin conjugate may be used to predict MDI-induced occupational asthma/eosinophilic bronchitis in MDI-exposed workers.

Original languageEnglish
Pages (from-to)586-593
Number of pages8
JournalClinical and Experimental Allergy
Volume38
Issue number4
DOIs
Publication statusPublished - 2008 Apr 1

Keywords

  • MDI
  • Occupational asthma
  • Occupational eosinophilic bronchitis
  • Specific IgE antibody
  • Specific IgG antibody
  • Specific inhalation challenge test

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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