Clinical and immunologic findings of methylene diphenyl diisocyanate-induced occupational asthma in a car upholstery factory

Gyu Young Hur, D. H. Koh, G. S. Choi, H. J. Park, S. J. Choi, Y. M. Ye, K. S. Kim, H. S. Park

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background: Although methylene diphenyl diisocyanate (MDI) is widely used in many industries, there have been few immunological studies of MDI-induced occupational asthma. Objectives: We investigated the effects of MDI exposure on the clinical and immunologic condition of workers in a single car upholstery factory. Methods: Fifty-eight MDI-exposed workers were studied. Work-related lower-respiratory symptoms (WRRS) were identified using a questionnaire. Serum-specific IgE and IgG antibodies to MDI-human serum albumin conjugate were detected by ELISA. Atopy was evaluated using a skin prick test. MDI-induced occupational asthma was confirmed in the symptomatic workers with a positive result on an MDI-specific inhalation test. Results: Thirteen (22.4%) of the subjects complained of WRRS. MDI-induced occupational asthma was confirmed in five (8.6%) of the workers, and occupational eosinophilic bronchitis was confirmed in two (3.5%). The prevalence of specific IgG antibodies (20.7%) was higher than that of specific IgE antibodies (8.6%). The prevalence of MDI-induced occupational asthma/eosinophilic bronchitis was strongly associated with the presence of both WRRS and serum-specific IgG antibodies to an MDI-human serum albumin conjugate (P<0.01, <0.05, respectively). Conclusion: These findings suggest that MDI could be a causative agent of occupational asthma among MDI-exposed workers. The prevalence of MDI-induced occupational asthma was 8.6%, and MDI-induced eosinophilic bronchitis was confirmed in two workers. The presence of work-related lower-respiratory symptoms and serum-specific IgG antibodies to an MDI-human serum albumin conjugate may be used to predict MDI-induced occupational asthma/eosinophilic bronchitis in MDI-exposed workers.

Original languageEnglish
Pages (from-to)586-593
Number of pages8
JournalClinical and Experimental Allergy
Volume38
Issue number4
DOIs
Publication statusPublished - 2008 Apr 1
Externally publishedYes

Fingerprint

Occupational Asthma
Bronchitis
Immunoglobulin G
Antibodies
Serum Albumin
4,4'-diphenylmethane diisocyanate
Immunoglobulin E
Serum

Keywords

  • MDI
  • Occupational asthma
  • Occupational eosinophilic bronchitis
  • Specific IgE antibody
  • Specific IgG antibody
  • Specific inhalation challenge test

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Clinical and immunologic findings of methylene diphenyl diisocyanate-induced occupational asthma in a car upholstery factory. / Hur, Gyu Young; Koh, D. H.; Choi, G. S.; Park, H. J.; Choi, S. J.; Ye, Y. M.; Kim, K. S.; Park, H. S.

In: Clinical and Experimental Allergy, Vol. 38, No. 4, 01.04.2008, p. 586-593.

Research output: Contribution to journalArticle

Hur, Gyu Young ; Koh, D. H. ; Choi, G. S. ; Park, H. J. ; Choi, S. J. ; Ye, Y. M. ; Kim, K. S. ; Park, H. S. / Clinical and immunologic findings of methylene diphenyl diisocyanate-induced occupational asthma in a car upholstery factory. In: Clinical and Experimental Allergy. 2008 ; Vol. 38, No. 4. pp. 586-593.
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abstract = "Background: Although methylene diphenyl diisocyanate (MDI) is widely used in many industries, there have been few immunological studies of MDI-induced occupational asthma. Objectives: We investigated the effects of MDI exposure on the clinical and immunologic condition of workers in a single car upholstery factory. Methods: Fifty-eight MDI-exposed workers were studied. Work-related lower-respiratory symptoms (WRRS) were identified using a questionnaire. Serum-specific IgE and IgG antibodies to MDI-human serum albumin conjugate were detected by ELISA. Atopy was evaluated using a skin prick test. MDI-induced occupational asthma was confirmed in the symptomatic workers with a positive result on an MDI-specific inhalation test. Results: Thirteen (22.4{\%}) of the subjects complained of WRRS. MDI-induced occupational asthma was confirmed in five (8.6{\%}) of the workers, and occupational eosinophilic bronchitis was confirmed in two (3.5{\%}). The prevalence of specific IgG antibodies (20.7{\%}) was higher than that of specific IgE antibodies (8.6{\%}). The prevalence of MDI-induced occupational asthma/eosinophilic bronchitis was strongly associated with the presence of both WRRS and serum-specific IgG antibodies to an MDI-human serum albumin conjugate (P<0.01, <0.05, respectively). Conclusion: These findings suggest that MDI could be a causative agent of occupational asthma among MDI-exposed workers. The prevalence of MDI-induced occupational asthma was 8.6{\%}, and MDI-induced eosinophilic bronchitis was confirmed in two workers. The presence of work-related lower-respiratory symptoms and serum-specific IgG antibodies to an MDI-human serum albumin conjugate may be used to predict MDI-induced occupational asthma/eosinophilic bronchitis in MDI-exposed workers.",
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AU - Choi, S. J.

AU - Ye, Y. M.

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