Abstract
Purpose: Despite the availability of molecular methods, identification of the causative virus in children with acute respiratory infections (ARIs) has proven difficult as the same viruses are often detected in asymptomatic children. Methods: Multiplex reverse transcription polymerase chain reaction assays were performed to detect 15 common respiratory viruses in children under 15 years of age who were hospitalized with ARI between January 2013 and December 2015. Viral epidemiology and clinical profiles of single virus infections were evaluated. Results: Of 3,505 patients, viruses were identified in 2,424 (69.1%), with the assay revealing a single virus in 1,747 cases (49.8%). While major pathogens in single virus-positive cases differed according to age, human rhinovirus (hRV) was common in patients of all ages. Respiratory syncytial virus (RSV), influenza virus (IF), and human metapneumovirus (hMPV) were found to be seasonal pathogens, appearing from fall through winter and spring, whereas hRV and adenovirus (AdV) were detected in every season. Patients with ARIs caused by RSV and hRV were frequently afebrile and more commonly had wheezing compared with patients with other viral ARIs. Neutrophil-dominant inflammation was observed in ARIs caused by IF, AdV, and hRV, whereas lymphocyte-dominant inflammation was observed with RSV A, parainfluenza virus, and hMPV. Monocytosis was common with RSV and AdV, whereas eosinophilia was observed with hRV. Conclusion: In combination with viral identification, recognition of virus-specific clinical and laboratory patterns will expand our understanding of the epidemiology of viral ARIs and help us to establish more efficient therapeutic and preventive strategies.
| Original language | English |
|---|---|
| Pages (from-to) | 180-186 |
| Number of pages | 7 |
| Journal | Korean Journal of Pediatrics |
| Volume | 61 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2018 Jun 1 |
Fingerprint
Keywords
- Child
- Clinical profile
- Epidemiology
- Multiplex RT-PCR
- Respiratory virus
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Pediatrics
Cite this
Clinical and laboratory profiles of hospitalized children with acute respiratory virus infection. / Choi, Eunjin; Ha, Kee Soo; Song, Dae-Jin; Lee, Jung Hwa; Lee, Kwang Chul.
In: Korean Journal of Pediatrics, Vol. 61, No. 6, 01.06.2018, p. 180-186.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical and laboratory profiles of hospitalized children with acute respiratory virus infection
AU - Choi, Eunjin
AU - Ha, Kee Soo
AU - Song, Dae-Jin
AU - Lee, Jung Hwa
AU - Lee, Kwang Chul
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Purpose: Despite the availability of molecular methods, identification of the causative virus in children with acute respiratory infections (ARIs) has proven difficult as the same viruses are often detected in asymptomatic children. Methods: Multiplex reverse transcription polymerase chain reaction assays were performed to detect 15 common respiratory viruses in children under 15 years of age who were hospitalized with ARI between January 2013 and December 2015. Viral epidemiology and clinical profiles of single virus infections were evaluated. Results: Of 3,505 patients, viruses were identified in 2,424 (69.1%), with the assay revealing a single virus in 1,747 cases (49.8%). While major pathogens in single virus-positive cases differed according to age, human rhinovirus (hRV) was common in patients of all ages. Respiratory syncytial virus (RSV), influenza virus (IF), and human metapneumovirus (hMPV) were found to be seasonal pathogens, appearing from fall through winter and spring, whereas hRV and adenovirus (AdV) were detected in every season. Patients with ARIs caused by RSV and hRV were frequently afebrile and more commonly had wheezing compared with patients with other viral ARIs. Neutrophil-dominant inflammation was observed in ARIs caused by IF, AdV, and hRV, whereas lymphocyte-dominant inflammation was observed with RSV A, parainfluenza virus, and hMPV. Monocytosis was common with RSV and AdV, whereas eosinophilia was observed with hRV. Conclusion: In combination with viral identification, recognition of virus-specific clinical and laboratory patterns will expand our understanding of the epidemiology of viral ARIs and help us to establish more efficient therapeutic and preventive strategies.
AB - Purpose: Despite the availability of molecular methods, identification of the causative virus in children with acute respiratory infections (ARIs) has proven difficult as the same viruses are often detected in asymptomatic children. Methods: Multiplex reverse transcription polymerase chain reaction assays were performed to detect 15 common respiratory viruses in children under 15 years of age who were hospitalized with ARI between January 2013 and December 2015. Viral epidemiology and clinical profiles of single virus infections were evaluated. Results: Of 3,505 patients, viruses were identified in 2,424 (69.1%), with the assay revealing a single virus in 1,747 cases (49.8%). While major pathogens in single virus-positive cases differed according to age, human rhinovirus (hRV) was common in patients of all ages. Respiratory syncytial virus (RSV), influenza virus (IF), and human metapneumovirus (hMPV) were found to be seasonal pathogens, appearing from fall through winter and spring, whereas hRV and adenovirus (AdV) were detected in every season. Patients with ARIs caused by RSV and hRV were frequently afebrile and more commonly had wheezing compared with patients with other viral ARIs. Neutrophil-dominant inflammation was observed in ARIs caused by IF, AdV, and hRV, whereas lymphocyte-dominant inflammation was observed with RSV A, parainfluenza virus, and hMPV. Monocytosis was common with RSV and AdV, whereas eosinophilia was observed with hRV. Conclusion: In combination with viral identification, recognition of virus-specific clinical and laboratory patterns will expand our understanding of the epidemiology of viral ARIs and help us to establish more efficient therapeutic and preventive strategies.
KW - Child
KW - Clinical profile
KW - Epidemiology
KW - Multiplex RT-PCR
KW - Respiratory virus
UR - http://www.scopus.com/inward/record.url?scp=85048958435&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85048958435&partnerID=8YFLogxK
U2 - 10.3345/kjp.2018.61.6.180
DO - 10.3345/kjp.2018.61.6.180
M3 - Article
AN - SCOPUS:85048958435
VL - 61
SP - 180
EP - 186
JO - Korean Journal of Pediatrics
JF - Korean Journal of Pediatrics
SN - 1783-1061
IS - 6
ER -