Clinical and metabolic factors associated with development and regression of nonalcoholic fatty liver disease in nonobese subjects

Nam Hoon Kim, Joo Hyung Kim, Yoon Jung Kim, Hye-Jin Yoo, Hee Young Kim, Ji A Seo, Nan Hee Kim, Kyung Mook Choi, Sei-Hyun Baik, Dong Seop Choi, Sin Gon Kim

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background & Aims: The course of NAFLD (nonalcoholic fatty liver disease) and associated factors in nonobese subjects are not well established. We investigated contributing factors for the development and regression of NAFLD in nonobese Koreans, and whether they would differ from those of obese subjects. Methods: Two thousand three hundred and seven adults aged over 18 years participated in this longitudinal observational study. The mean duration of follow-up was 28.7 (±13.2) months. The participants were divided into two groups according to the baseline BMI (nonobese group: BMI <25 kg/m2, obese group: BMI ≥25 kg/m2). The presence or absence of NAFLD was assessed by abdominal ultrasonography. Results: Body weight change was independently associated with both the development and regression of NAFLD in nonobese subjects as well as obese subjects. Among the subjects who developed NAFLD, the amount of weight change was higher in nonobese subjects compared to obese subjects (1.6 ± 3.9% vs 0.6 ± 4.2%, P = 0.022); and among those who showed regression of NAFLD, the amount of weight change was lower in nonobese subjects (-1.9 ± 4.0% vs -5.0 ± 4.6%, P < 0.001). Among all the components of metabolic syndrome, only high triglyceride levels (>150 mg/dl) at the baseline were significantly associated with both the development and regression of NAFLD in nonobese subjects (ORs, 1.54 (1.10-2.14), and 0.60 (0.38-0.96) respectively). Conclusion: Body weight change and baseline triglyceride levels were strong indicators for the development and regression of NAFLD in a nonobese population.

Original languageEnglish
Pages (from-to)604-611
Number of pages8
JournalLiver International
Volume34
Issue number4
DOIs
Publication statusPublished - 2014 Jan 1

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Body Weight Changes
Observational Studies
Longitudinal Studies
Triglycerides
Non-alcoholic Fatty Liver Disease
Population

Keywords

  • Hypertriglyceridaemia
  • Metabolic syndrome
  • Nonalcoholic fatty liver disease
  • Nonobese
  • Weight loss

ASJC Scopus subject areas

  • Hepatology

Cite this

Clinical and metabolic factors associated with development and regression of nonalcoholic fatty liver disease in nonobese subjects. / Kim, Nam Hoon; Kim, Joo Hyung; Kim, Yoon Jung; Yoo, Hye-Jin; Kim, Hee Young; Seo, Ji A; Kim, Nan Hee; Choi, Kyung Mook; Baik, Sei-Hyun; Choi, Dong Seop; Kim, Sin Gon.

In: Liver International, Vol. 34, No. 4, 01.01.2014, p. 604-611.

Research output: Contribution to journalArticle

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abstract = "Background & Aims: The course of NAFLD (nonalcoholic fatty liver disease) and associated factors in nonobese subjects are not well established. We investigated contributing factors for the development and regression of NAFLD in nonobese Koreans, and whether they would differ from those of obese subjects. Methods: Two thousand three hundred and seven adults aged over 18 years participated in this longitudinal observational study. The mean duration of follow-up was 28.7 (±13.2) months. The participants were divided into two groups according to the baseline BMI (nonobese group: BMI <25 kg/m2, obese group: BMI ≥25 kg/m2). The presence or absence of NAFLD was assessed by abdominal ultrasonography. Results: Body weight change was independently associated with both the development and regression of NAFLD in nonobese subjects as well as obese subjects. Among the subjects who developed NAFLD, the amount of weight change was higher in nonobese subjects compared to obese subjects (1.6 ± 3.9{\%} vs 0.6 ± 4.2{\%}, P = 0.022); and among those who showed regression of NAFLD, the amount of weight change was lower in nonobese subjects (-1.9 ± 4.0{\%} vs -5.0 ± 4.6{\%}, P < 0.001). Among all the components of metabolic syndrome, only high triglyceride levels (>150 mg/dl) at the baseline were significantly associated with both the development and regression of NAFLD in nonobese subjects (ORs, 1.54 (1.10-2.14), and 0.60 (0.38-0.96) respectively). Conclusion: Body weight change and baseline triglyceride levels were strong indicators for the development and regression of NAFLD in a nonobese population.",
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T1 - Clinical and metabolic factors associated with development and regression of nonalcoholic fatty liver disease in nonobese subjects

AU - Kim, Nam Hoon

AU - Kim, Joo Hyung

AU - Kim, Yoon Jung

AU - Yoo, Hye-Jin

AU - Kim, Hee Young

AU - Seo, Ji A

AU - Kim, Nan Hee

AU - Choi, Kyung Mook

AU - Baik, Sei-Hyun

AU - Choi, Dong Seop

AU - Kim, Sin Gon

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AB - Background & Aims: The course of NAFLD (nonalcoholic fatty liver disease) and associated factors in nonobese subjects are not well established. We investigated contributing factors for the development and regression of NAFLD in nonobese Koreans, and whether they would differ from those of obese subjects. Methods: Two thousand three hundred and seven adults aged over 18 years participated in this longitudinal observational study. The mean duration of follow-up was 28.7 (±13.2) months. The participants were divided into two groups according to the baseline BMI (nonobese group: BMI <25 kg/m2, obese group: BMI ≥25 kg/m2). The presence or absence of NAFLD was assessed by abdominal ultrasonography. Results: Body weight change was independently associated with both the development and regression of NAFLD in nonobese subjects as well as obese subjects. Among the subjects who developed NAFLD, the amount of weight change was higher in nonobese subjects compared to obese subjects (1.6 ± 3.9% vs 0.6 ± 4.2%, P = 0.022); and among those who showed regression of NAFLD, the amount of weight change was lower in nonobese subjects (-1.9 ± 4.0% vs -5.0 ± 4.6%, P < 0.001). Among all the components of metabolic syndrome, only high triglyceride levels (>150 mg/dl) at the baseline were significantly associated with both the development and regression of NAFLD in nonobese subjects (ORs, 1.54 (1.10-2.14), and 0.60 (0.38-0.96) respectively). Conclusion: Body weight change and baseline triglyceride levels were strong indicators for the development and regression of NAFLD in a nonobese population.

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KW - Metabolic syndrome

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KW - Nonobese

KW - Weight loss

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