Clinical and microbiological characterization of serotype 6D pneumococcal infections in South Korea

Hee Jin Cheong, Joon Young Song, Min Joo Choi, Ji Ho Jeon, Seong Hee Kang, Eun Joo Jeong, Ji Yun Noh, Woo Joo Kim

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Background The prevalence of Serotype 6D Streptococcus pneumoniae was reported relatively high in South Korea. Since the introduction of 7-valent pneumococcal conjugate vaccine (PCV7), serotype replacement was observed. This study was designed to better clarify genetic diversity of pneumococcal serotype 6D and its clinical characteristics after introduction of PCV7 in 2000. Methods We performed serotyping analysis with 1298 pneumococcal isolates from clinical specimens in South Korea from 2004 to 2011. Multilocus sequence typing was performed, and minimal inhibitory concentration was determined for the available serotype 6D and nontypeable (NT) pneumococcal isolates during the 2006–2007 period. Results The proportion of serotype 6D pneumococci increased from 0.8% (2004–2007) to 2.9% (2008–2011) of all clinical pneumococcal isolates, accounting for 14.9% of serogroup 6 pneumococci in South Korea. NT pneumococci markedly increased to 13.3% during 2006–2007 in advance of the increase in serotype 6D. Among the 26 available serotype 6D pneumococcal isolates, ST282 was predominant (23 isolates, 88.5%). The STs of NT pneumococci (26 isolates) were diverse, but clonal complex 271 was the dominant clone. The oral penicillin non-susceptibility rate was 92.3% (24 among 26 isolates) for both serotype 6D and NT pneumococci. The ceftriaxone non-susceptibility rates of serotype 6D and NT pneumococci were 7.7% and 3.8%, respectively. Conclusion ST2286D strain expanded, particularly among old adults with comorbidities in South Korea. Both antibiotic and PCV7 pressure might have contributed to the selective increase of NT and serotype 6D pneumococci.

Original languageEnglish
Pages (from-to)515-520
Number of pages6
JournalJournal of Infection and Chemotherapy
Issue number8
Publication statusPublished - 2016 Aug 1
Externally publishedYes


  • Capsular serotype
  • Multilocus sequence typing
  • Serotyping
  • Streptococcus pneumoniae

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)


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