Clinical and molecular epidemiological features of hemorrhagic fever with renal syndrome in Korea over a 10-year period

Ji Yun Noh, Hee-Jin Cheong, Joon-Young Song, Woo Joo Kim, Ki-Joon Song, Terry A. Klein, Sam H. Lee, Richard Yanagihara, Jin Won Song

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Laboratory diagnosis of hemorrhagic fever with renal syndrome (HFRS), an infectious disease caused by rodent-borne hantaviruses in Asia and Europe, depends primarily on serological methods. Since the advent of such serodiagnostic tests, few reports are available about the clinical and molecular epidemiological features of HFRS. Objectives: To investigate the epidemioclinical features of HFRS patients treated at a tertiary-care teaching hospital in Seoul over a 10-year period. Study design: Medical records of HFRS patients, admitted to a tertiary-care teaching hospital during February 2002 to February 2012, were reviewed. Sera from patients were tested for Hantaan virus (HTNV) and Seoul virus (SEOV) RNA using RT-PCR. Results: Among 35 HFRS patients (mean age was 44.2. ±. 14.7 years), 29 were male (82.9%). Acute renal failure developed in 27 patients (77.1%), and 12 patients (34.3%) were admitted to the intensive care unit (ICU). Conjunctival injection (OR 10.32, 95% CI 1.09-97.77, P = .04) and initial serum albumin less than 3. g/dL (OR 22.83, 95% CI 1.45-359.93, P = .03) were risk factors for ICU admission. Of 35 acute-phase sera, 11 (31.4%) were positive for HTNV RNA. None were positive for SEOV RNA. Conclusions: HFRS was characterized by the clinical triad of fever, renal insufficiency and gastrointestinal symptoms. Conjunctival injection and serum albumin level were related to severity. A large-scale multi-center study is needed to enhance insights into epidemioclinical characteristics of HFRS in Korea.

Original languageEnglish
Pages (from-to)11-17
Number of pages7
JournalJournal of Clinical Virology
Volume58
Issue number1
DOIs
Publication statusPublished - 2013 Sep 1

Fingerprint

Hemorrhagic Fever with Renal Syndrome
Korea
Seoul virus
Hantaan virus
RNA
Tertiary Healthcare
Serum Albumin
Teaching Hospitals
Intensive Care Units
Hantavirus
Injections
Clinical Laboratory Techniques
Serum
Acute Kidney Injury
Medical Records
Renal Insufficiency
Communicable Diseases
Rodentia
Fever
Polymerase Chain Reaction

Keywords

  • Hantaan virus
  • Hantavirus
  • Hemorrhagic fever with renal syndrome
  • Korea

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

@article{45794ed4423946959863f80065c32f89,
title = "Clinical and molecular epidemiological features of hemorrhagic fever with renal syndrome in Korea over a 10-year period",
abstract = "Background: Laboratory diagnosis of hemorrhagic fever with renal syndrome (HFRS), an infectious disease caused by rodent-borne hantaviruses in Asia and Europe, depends primarily on serological methods. Since the advent of such serodiagnostic tests, few reports are available about the clinical and molecular epidemiological features of HFRS. Objectives: To investigate the epidemioclinical features of HFRS patients treated at a tertiary-care teaching hospital in Seoul over a 10-year period. Study design: Medical records of HFRS patients, admitted to a tertiary-care teaching hospital during February 2002 to February 2012, were reviewed. Sera from patients were tested for Hantaan virus (HTNV) and Seoul virus (SEOV) RNA using RT-PCR. Results: Among 35 HFRS patients (mean age was 44.2. ±. 14.7 years), 29 were male (82.9{\%}). Acute renal failure developed in 27 patients (77.1{\%}), and 12 patients (34.3{\%}) were admitted to the intensive care unit (ICU). Conjunctival injection (OR 10.32, 95{\%} CI 1.09-97.77, P = .04) and initial serum albumin less than 3. g/dL (OR 22.83, 95{\%} CI 1.45-359.93, P = .03) were risk factors for ICU admission. Of 35 acute-phase sera, 11 (31.4{\%}) were positive for HTNV RNA. None were positive for SEOV RNA. Conclusions: HFRS was characterized by the clinical triad of fever, renal insufficiency and gastrointestinal symptoms. Conjunctival injection and serum albumin level were related to severity. A large-scale multi-center study is needed to enhance insights into epidemioclinical characteristics of HFRS in Korea.",
keywords = "Hantaan virus, Hantavirus, Hemorrhagic fever with renal syndrome, Korea",
author = "Noh, {Ji Yun} and Hee-Jin Cheong and Joon-Young Song and Kim, {Woo Joo} and Ki-Joon Song and Klein, {Terry A.} and Lee, {Sam H.} and Richard Yanagihara and Song, {Jin Won}",
year = "2013",
month = "9",
day = "1",
doi = "10.1016/j.jcv.2013.06.027",
language = "English",
volume = "58",
pages = "11--17",
journal = "Journal of Clinical Virology",
issn = "1386-6532",
publisher = "Elsevier",
number = "1",

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TY - JOUR

T1 - Clinical and molecular epidemiological features of hemorrhagic fever with renal syndrome in Korea over a 10-year period

AU - Noh, Ji Yun

AU - Cheong, Hee-Jin

AU - Song, Joon-Young

AU - Kim, Woo Joo

AU - Song, Ki-Joon

AU - Klein, Terry A.

AU - Lee, Sam H.

AU - Yanagihara, Richard

AU - Song, Jin Won

PY - 2013/9/1

Y1 - 2013/9/1

N2 - Background: Laboratory diagnosis of hemorrhagic fever with renal syndrome (HFRS), an infectious disease caused by rodent-borne hantaviruses in Asia and Europe, depends primarily on serological methods. Since the advent of such serodiagnostic tests, few reports are available about the clinical and molecular epidemiological features of HFRS. Objectives: To investigate the epidemioclinical features of HFRS patients treated at a tertiary-care teaching hospital in Seoul over a 10-year period. Study design: Medical records of HFRS patients, admitted to a tertiary-care teaching hospital during February 2002 to February 2012, were reviewed. Sera from patients were tested for Hantaan virus (HTNV) and Seoul virus (SEOV) RNA using RT-PCR. Results: Among 35 HFRS patients (mean age was 44.2. ±. 14.7 years), 29 were male (82.9%). Acute renal failure developed in 27 patients (77.1%), and 12 patients (34.3%) were admitted to the intensive care unit (ICU). Conjunctival injection (OR 10.32, 95% CI 1.09-97.77, P = .04) and initial serum albumin less than 3. g/dL (OR 22.83, 95% CI 1.45-359.93, P = .03) were risk factors for ICU admission. Of 35 acute-phase sera, 11 (31.4%) were positive for HTNV RNA. None were positive for SEOV RNA. Conclusions: HFRS was characterized by the clinical triad of fever, renal insufficiency and gastrointestinal symptoms. Conjunctival injection and serum albumin level were related to severity. A large-scale multi-center study is needed to enhance insights into epidemioclinical characteristics of HFRS in Korea.

AB - Background: Laboratory diagnosis of hemorrhagic fever with renal syndrome (HFRS), an infectious disease caused by rodent-borne hantaviruses in Asia and Europe, depends primarily on serological methods. Since the advent of such serodiagnostic tests, few reports are available about the clinical and molecular epidemiological features of HFRS. Objectives: To investigate the epidemioclinical features of HFRS patients treated at a tertiary-care teaching hospital in Seoul over a 10-year period. Study design: Medical records of HFRS patients, admitted to a tertiary-care teaching hospital during February 2002 to February 2012, were reviewed. Sera from patients were tested for Hantaan virus (HTNV) and Seoul virus (SEOV) RNA using RT-PCR. Results: Among 35 HFRS patients (mean age was 44.2. ±. 14.7 years), 29 were male (82.9%). Acute renal failure developed in 27 patients (77.1%), and 12 patients (34.3%) were admitted to the intensive care unit (ICU). Conjunctival injection (OR 10.32, 95% CI 1.09-97.77, P = .04) and initial serum albumin less than 3. g/dL (OR 22.83, 95% CI 1.45-359.93, P = .03) were risk factors for ICU admission. Of 35 acute-phase sera, 11 (31.4%) were positive for HTNV RNA. None were positive for SEOV RNA. Conclusions: HFRS was characterized by the clinical triad of fever, renal insufficiency and gastrointestinal symptoms. Conjunctival injection and serum albumin level were related to severity. A large-scale multi-center study is needed to enhance insights into epidemioclinical characteristics of HFRS in Korea.

KW - Hantaan virus

KW - Hantavirus

KW - Hemorrhagic fever with renal syndrome

KW - Korea

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U2 - 10.1016/j.jcv.2013.06.027

DO - 10.1016/j.jcv.2013.06.027

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