Clinical characteristics and corticosteroid treatment of acute eosinophilic pneumonia

Chin Kook Rhee, Kyung-Hoon Min, Nam Yeol Yim, Ji Eun Lee, Na Rae Lee, Man Pyo Chung, Kyeongman Jeon

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

The clinical characteristics and optimal duration of corticosteroid treatment for acute eosinophilic pneumonia (AEP) have not been fully evaluated. This was a retrospective study of prospectively collected data from 137 patients with AEP, treated with standardised protocol, to clarify the clinical characteristics and compare the efficacies of 2 weeks versus 4 weeks of corticosteroid treatment for AEP. The majority of the patients altered their smoking habits within a median (interquartile range) of 17 (13-26) days prior to development of AEP. 80 (58%) patients presented with acute respiratory failure. A total of 127 (92%) patients were treated with corticosteroids: 4 weeks, n=42; 2 weeks, n=85. Major symptoms were resolved in 3 days and the severity of respiratory failure was inversely correlated with clinical outcomes. After adjusting for differences in baseline characteristics between the groups, the differences in adjusted mean (95% confidence interval) for resolution of dyspnoea and disappearance of all symptoms were 0.57 (-0.71-1.86) and -0.04 (-1.91-1.83) days, respectively. The difference in adjusted proportion of resolution of radiological abnormalities was 6.92% (-8.19-22.02). In conclusion, the duration of corticosteroid treatment could be shortened to 2 weeks, even in patients with respiratory failure.

Original languageEnglish
Pages (from-to)402-409
Number of pages8
JournalEuropean Respiratory Journal
Volume41
Issue number2
DOIs
Publication statusPublished - 2013 Feb 1

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Pulmonary Eosinophilia
Adrenal Cortex Hormones
Respiratory Insufficiency
Therapeutics
Dyspnea
Habits
Retrospective Studies
Smoking
Confidence Intervals

Keywords

  • Acute disease
  • Pulmonary eosinophilia
  • Respiratory insufficiency
  • Smoking
  • Treatment outcome

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Clinical characteristics and corticosteroid treatment of acute eosinophilic pneumonia. / Rhee, Chin Kook; Min, Kyung-Hoon; Yim, Nam Yeol; Lee, Ji Eun; Lee, Na Rae; Chung, Man Pyo; Jeon, Kyeongman.

In: European Respiratory Journal, Vol. 41, No. 2, 01.02.2013, p. 402-409.

Research output: Contribution to journalArticle

Rhee, Chin Kook ; Min, Kyung-Hoon ; Yim, Nam Yeol ; Lee, Ji Eun ; Lee, Na Rae ; Chung, Man Pyo ; Jeon, Kyeongman. / Clinical characteristics and corticosteroid treatment of acute eosinophilic pneumonia. In: European Respiratory Journal. 2013 ; Vol. 41, No. 2. pp. 402-409.
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