Clinical characteristics and outcome of multiple sclerosis in Korea: Does multiple sclerosis in Korea really differ from that in the Caucasian populations?

Su Hyun Kim, So Young Huh, Woojun Kim, Min Su Park, Suk Won Ahn, Joong Yang Cho, Byung Jo Kim, Ho Jin Kim

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Background: Multiple sclerosis (MS) in Asia is thought to have different clinical characteristics from MS in Western countries; however, previous studies in Asia were performed without properly differentiating neuromyelitis optica (NMO) from MS. Objectives: To evaluate the clinical characteristics of MS in Korea after careful exclusion of potential explanations other than MS, particularly NMO spectrum disorder (NMOSD). Methods: This study is a retrospective review of consecutive MS patients attending five referral hospitals in Korea. All patients MS diagnoses were re-evaluated. Results: Of the 105 patients, 70 were female and 35 were male. The mean age of onset was 30.4 years and the mean disease duration was 5.4 years. On initial magnetic resonance imaging (MRI), 58% and 64% fulfilled the criteria for dissemination in space for the 2005 and 2010 McDonald criteria, respectively. Spinal cord lesions were observed in 78% of patients, primarily present as multiple small lesions with a mean length of 0.9 vertebral segments. The median time from disease onset to an Expanded Disability Status Scale 6 was 20 years. Conclusions: After careful exclusion of NMOSD, we found that the clinical pattern of MS in Korea does not fundamentally differ from that seen in Western countries.

Original languageEnglish
Pages (from-to)1493-1498
Number of pages6
JournalMultiple Sclerosis Journal
Volume19
Issue number11
DOIs
Publication statusPublished - 2013 Oct

Keywords

  • Asia
  • Korea
  • Multiple sclerosis
  • beta-interferon
  • clinical characteristics
  • epidemiology
  • neuromyelitis optica
  • optic-spinal multiple sclerosis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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