Clinical characteristics and outcomes of acute hepatitis a in Korea

A nationwide multicenter study

So Young Kwon, Sang Hoon Park, Jong Eun Yeon, Sook Hyang Jeong, Oh Sang Kwon, Jin Woo Lee, Hong Soo Kim, Yeon Seok Seo, Young Seok Kim, Joo Hyun Sohn, Hyung Joon Yim, Jong Young Choi, Myung Seok Lee, Young Oh Kweon, Jae Youn Cheong, Haak Cheoul Kim, Heon Ju Lee, Soon Koo Baik, Hyonggin An, Kwan Soo Byun

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The aim of this study was to investigate the clinical characteristics of acute hepatitis A during a recent outbreak in Korea. Data of patients diagnosed with acute hepatitis A from 2007 to 2009 were collected from 21 tertiary hospitals retrospectively. Their demographic, clinical, and serological characteristics and their clinical outcomes were analyzed. A total of 4,218 patients (mean age 33.3 yr) were included. The median duration of admission was 9 days. The mean of the highest ALT level was 2,963 IU/L, total bilirubin was 7.3 mg/dL, prothrombin time INR was 1.3. HBsAg was positive in 3.7%, and anti-HCV positive in 0.7%. Renal insufficiency occurred in 2.7%, hepatic failure in 0.9%, relapsing hepatitis in 0.7%, and cholestatic hepatitis in 1.9% of the patients. Nineteen patients (0.45%) died or were transplanted. Complications of renal failure or prolonged cholestasis were more frequent in patients older than 30 yr. In conclusion, most patients with acute hepatitis A recover uneventfully, however, complication rates are higher in patients older than 30 yr than younger patients. Preventive strategies including universal vaccination in infants and active immunization of hepatitis A to adult population should be considered for prevention of community-wide outbreaks of hepatitis A in Korea.

Original languageEnglish
Pages (from-to)248-253
Number of pages6
JournalJournal of Korean Medical Science
Volume29
Issue number2
DOIs
Publication statusPublished - 2014 Jan 1

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Korea
Hepatitis
Multicenter Studies
Hepatitis A
Renal Insufficiency
Disease Outbreaks
Vaccination
International Normalized Ratio
Cholestasis
Prothrombin Time
Liver Failure
Hepatitis B Surface Antigens
Bilirubin
Tertiary Care Centers
Demography
Population

Keywords

  • Hepatitis A
  • Morbidity
  • Mortality

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Clinical characteristics and outcomes of acute hepatitis a in Korea : A nationwide multicenter study. / Kwon, So Young; Park, Sang Hoon; Yeon, Jong Eun; Jeong, Sook Hyang; Kwon, Oh Sang; Lee, Jin Woo; Kim, Hong Soo; Seo, Yeon Seok; Kim, Young Seok; Sohn, Joo Hyun; Yim, Hyung Joon; Choi, Jong Young; Lee, Myung Seok; Kweon, Young Oh; Cheong, Jae Youn; Kim, Haak Cheoul; Lee, Heon Ju; Baik, Soon Koo; An, Hyonggin; Byun, Kwan Soo.

In: Journal of Korean Medical Science, Vol. 29, No. 2, 01.01.2014, p. 248-253.

Research output: Contribution to journalArticle

Kwon, SY, Park, SH, Yeon, JE, Jeong, SH, Kwon, OS, Lee, JW, Kim, HS, Seo, YS, Kim, YS, Sohn, JH, Yim, HJ, Choi, JY, Lee, MS, Kweon, YO, Cheong, JY, Kim, HC, Lee, HJ, Baik, SK, An, H & Byun, KS 2014, 'Clinical characteristics and outcomes of acute hepatitis a in Korea: A nationwide multicenter study', Journal of Korean Medical Science, vol. 29, no. 2, pp. 248-253. https://doi.org/10.3346/jkms.2014.29.2.248
Kwon, So Young ; Park, Sang Hoon ; Yeon, Jong Eun ; Jeong, Sook Hyang ; Kwon, Oh Sang ; Lee, Jin Woo ; Kim, Hong Soo ; Seo, Yeon Seok ; Kim, Young Seok ; Sohn, Joo Hyun ; Yim, Hyung Joon ; Choi, Jong Young ; Lee, Myung Seok ; Kweon, Young Oh ; Cheong, Jae Youn ; Kim, Haak Cheoul ; Lee, Heon Ju ; Baik, Soon Koo ; An, Hyonggin ; Byun, Kwan Soo. / Clinical characteristics and outcomes of acute hepatitis a in Korea : A nationwide multicenter study. In: Journal of Korean Medical Science. 2014 ; Vol. 29, No. 2. pp. 248-253.
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abstract = "The aim of this study was to investigate the clinical characteristics of acute hepatitis A during a recent outbreak in Korea. Data of patients diagnosed with acute hepatitis A from 2007 to 2009 were collected from 21 tertiary hospitals retrospectively. Their demographic, clinical, and serological characteristics and their clinical outcomes were analyzed. A total of 4,218 patients (mean age 33.3 yr) were included. The median duration of admission was 9 days. The mean of the highest ALT level was 2,963 IU/L, total bilirubin was 7.3 mg/dL, prothrombin time INR was 1.3. HBsAg was positive in 3.7{\%}, and anti-HCV positive in 0.7{\%}. Renal insufficiency occurred in 2.7{\%}, hepatic failure in 0.9{\%}, relapsing hepatitis in 0.7{\%}, and cholestatic hepatitis in 1.9{\%} of the patients. Nineteen patients (0.45{\%}) died or were transplanted. Complications of renal failure or prolonged cholestasis were more frequent in patients older than 30 yr. In conclusion, most patients with acute hepatitis A recover uneventfully, however, complication rates are higher in patients older than 30 yr than younger patients. Preventive strategies including universal vaccination in infants and active immunization of hepatitis A to adult population should be considered for prevention of community-wide outbreaks of hepatitis A in Korea.",
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AU - Kwon, Oh Sang

AU - Lee, Jin Woo

AU - Kim, Hong Soo

AU - Seo, Yeon Seok

AU - Kim, Young Seok

AU - Sohn, Joo Hyun

AU - Yim, Hyung Joon

AU - Choi, Jong Young

AU - Lee, Myung Seok

AU - Kweon, Young Oh

AU - Cheong, Jae Youn

AU - Kim, Haak Cheoul

AU - Lee, Heon Ju

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AU - An, Hyonggin

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AB - The aim of this study was to investigate the clinical characteristics of acute hepatitis A during a recent outbreak in Korea. Data of patients diagnosed with acute hepatitis A from 2007 to 2009 were collected from 21 tertiary hospitals retrospectively. Their demographic, clinical, and serological characteristics and their clinical outcomes were analyzed. A total of 4,218 patients (mean age 33.3 yr) were included. The median duration of admission was 9 days. The mean of the highest ALT level was 2,963 IU/L, total bilirubin was 7.3 mg/dL, prothrombin time INR was 1.3. HBsAg was positive in 3.7%, and anti-HCV positive in 0.7%. Renal insufficiency occurred in 2.7%, hepatic failure in 0.9%, relapsing hepatitis in 0.7%, and cholestatic hepatitis in 1.9% of the patients. Nineteen patients (0.45%) died or were transplanted. Complications of renal failure or prolonged cholestasis were more frequent in patients older than 30 yr. In conclusion, most patients with acute hepatitis A recover uneventfully, however, complication rates are higher in patients older than 30 yr than younger patients. Preventive strategies including universal vaccination in infants and active immunization of hepatitis A to adult population should be considered for prevention of community-wide outbreaks of hepatitis A in Korea.

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