Clinical characteristics and psychotropic prescribing patterns associated with impaired concentration in asians with depressive disorders

The REAP-AD study

Seon Cheol Park, Min-Soo Lee, Sang Woo Hahn, Shigenobu Kanba, Mian Yoon Chong, Kok Yoon Chee, Pichet Udomratn, Adarsh Tripathi, Norman Sartorius, Naotaka Shinfuku, Andi J. Tanra, Yong Chon Park

Research output: Contribution to journalArticle

Abstract

The Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP-AD) study aimed to survey and review antidepressant prescribing patterns in different clinical settings in Asian countries/areas. The REAP-AD study collected comprehensive data for psychiatric patients prescribed antidepressants in 10 Asian countries/areas during the period from March to June 2013. Depressive disorders have been an important issue closely associated with ill-health and disability in the realm of mental health. Impaired concentration was found to be a consistent symptom in depressive disorders regardless of clinical course, and a predictor of poor treatment outcome. In this work we aimed to identify clinical characteristics independently associated with impaired concentration in patients with depressive disorders, using data from the REAP-AD study. A total of 336 depressive disorder patients with impaired concentration and 786 depressive disorder patients without impaired concentration were recruited from 40 centers in 10 Asian countries/areas. A binary logistic regression model was fitted to identify the independent correlates of impaired concentration in patients with depressive disorders. After adjusting the effects of covariates, the binary logistic model showed that impaired concentration was independently associated with higher rates of loss of interest (P < 0.0001), fatigue (P < 0.0001), low self-confidence (P < 0.0001) and appetite disturbance (P < 0.0001) and with a lower rate of adjunctive antipsychotic prescription (P = 0.007). Our findings suggest that impaired concentration and its associated depressive symptom profiles constitute a unitary depressive symptom cluster that is also an intervening variable for poor social function.

Original languageEnglish
Pages (from-to)151-156
Number of pages6
JournalTohoku Journal of Experimental Medicine
Volume242
Issue number2
DOIs
Publication statusPublished - 2017 Jun 1

Fingerprint

Depressive Disorder
Antidepressive Agents
Logistics
Health
Logistic Models
Antipsychotic Agents
Prescriptions
Fatigue of materials
Depression
Appetite
Fatigue
Psychiatry
Mental Health
Research

Keywords

  • Asian
  • Depressive disorders
  • Impaired concentration
  • Social function
  • Symptom cluster

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Clinical characteristics and psychotropic prescribing patterns associated with impaired concentration in asians with depressive disorders : The REAP-AD study. / Park, Seon Cheol; Lee, Min-Soo; Hahn, Sang Woo; Kanba, Shigenobu; Chong, Mian Yoon; Chee, Kok Yoon; Udomratn, Pichet; Tripathi, Adarsh; Sartorius, Norman; Shinfuku, Naotaka; Tanra, Andi J.; Park, Yong Chon.

In: Tohoku Journal of Experimental Medicine, Vol. 242, No. 2, 01.06.2017, p. 151-156.

Research output: Contribution to journalArticle

Park, SC, Lee, M-S, Hahn, SW, Kanba, S, Chong, MY, Chee, KY, Udomratn, P, Tripathi, A, Sartorius, N, Shinfuku, N, Tanra, AJ & Park, YC 2017, 'Clinical characteristics and psychotropic prescribing patterns associated with impaired concentration in asians with depressive disorders: The REAP-AD study', Tohoku Journal of Experimental Medicine, vol. 242, no. 2, pp. 151-156. https://doi.org/10.1620/tjem.242.151
Park, Seon Cheol ; Lee, Min-Soo ; Hahn, Sang Woo ; Kanba, Shigenobu ; Chong, Mian Yoon ; Chee, Kok Yoon ; Udomratn, Pichet ; Tripathi, Adarsh ; Sartorius, Norman ; Shinfuku, Naotaka ; Tanra, Andi J. ; Park, Yong Chon. / Clinical characteristics and psychotropic prescribing patterns associated with impaired concentration in asians with depressive disorders : The REAP-AD study. In: Tohoku Journal of Experimental Medicine. 2017 ; Vol. 242, No. 2. pp. 151-156.
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